Dimethylsulfoxide reduces the X-ray-induced G2 delay in Chinese hamster ovary cells.

HIROSHI KIMURA

doi:10.1269/jrr.27.277

Dimethylsulfoxide reduces the X-ray-induced G2 delay in Chinese hamster ovary cells.

Journal of Radiation Research ◽

10.1269/jrr.27.277 ◽

1986 ◽

Vol 27 (3) ◽

pp. 277-283 ◽

Cited By ~ 1

Author(s):

HIROSHI KIMURA

Keyword(s):

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

X Ray ◽

G2 Delay

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X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

Mutation Research/DNA Repair Reports ◽

10.1016/0167-8817(84)90037-3 ◽

1984 ◽

Vol 132 (5-6) ◽

pp. 189-196 ◽

Cited By ~ 168

Author(s):

L.M. Kemp ◽

S.G. Sedgwick ◽

P.A. Jeggo

Keyword(s):

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Strand Break ◽

Double Strand Break ◽

Ovary Cells ◽

X Ray

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X-Ray Induction of 8-Azaguanine-Resistant Mutants in Synchronous Chinese Hamster Ovary Cells

Radiation Research ◽

10.2307/3575266 ◽

1980 ◽

Vol 83 (1) ◽

pp. 146 ◽

Cited By ~ 35

Author(s):

R. F. Jostes ◽

K. M. Bushnell ◽

W. C. Dewey

Keyword(s):

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

X Ray ◽

Resistant Mutants

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Molecular characterization of X-ray-induced mutations at the HPRT locus in plateau-phase Chinese hamster ovary cells

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/0027-5107(90)90122-k ◽

1990 ◽

Vol 232 (2) ◽

pp. 171-182 ◽

Cited By ~ 41

Author(s):

Thomas L. Morgan ◽

Earl W. Fleck ◽

Kathy A. Poston ◽

Barbara A. Denovan ◽

C.N. Newman ◽

...

Keyword(s):

Molecular Characterization ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Plateau Phase ◽

Induced Mutations ◽

Ovary Cells ◽

X Ray ◽

Hprt Locus

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The application of the microbial “tooth-pick” technique to somatic cell genetics, and its use in the isolation of X-ray sensitive mutants of chinese hamster ovary cells

Biochimie ◽

10.1016/s0300-9084(82)80116-8 ◽

1982 ◽

Vol 64 (8-9) ◽

pp. 713-715 ◽

Cited By ~ 37

Author(s):

P.A. Jeggo ◽

L.M. Kemp ◽

R. Holliday

Keyword(s):

Somatic Cell ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Somatic Cell Genetics ◽

Ovary Cells ◽

X Ray

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X-ray-induced DNA Double-strand Breaks as Lethal Lesions in Diploid Human Fibroblasts Compared to Chinese Hamster Ovary Cells

International Journal of Radiation Biology ◽

10.1080/09553009314550411 ◽

1993 ◽

Vol 63 (3) ◽

pp. 305-311 ◽

Cited By ~ 11

Author(s):

C. Baumstark-Khan

Keyword(s):

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Human Fibroblasts ◽

Chinese Hamster ◽

Double Strand Breaks ◽

Dna Double Strand Breaks ◽

Ovary Cells ◽

Strand Breaks ◽

X Ray

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X-ray induction of 6-thioguanine-resistant mutants in division arrested, G0/G1 phase Chinese hamster ovary cells

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/0027-5107(85)90141-1 ◽

1985 ◽

Vol 150 (1-2) ◽

pp. 443-450 ◽

Cited By ~ 11

Author(s):

J. Patrick O'Neill ◽

Kimberly B. Flint

Keyword(s):

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

G1 Phase ◽

Ovary Cells ◽

X Ray ◽

Resistant Mutants

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X-ray response of Chinese hamster ovary cells during the latter part of G2

Biophysical Journal ◽

10.1016/s0006-3495(79)85195-4 ◽

1979 ◽

Vol 28 (3) ◽

pp. 497-501 ◽

Cited By ~ 5

Author(s):

T.D. Griffiths

Keyword(s):

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

X Ray

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Malignancy-related characteristics of wild type and drug-resistant chinese hamster ovary cells

Pathology ◽

10.3109/00313029309066588 ◽

1993 ◽

Vol 25 (3) ◽

pp. 268-276 ◽

Cited By ~ 5

Author(s):

Wanda B. Mackinnon ◽

Marlen Dyne ◽

Rebecca Hancock ◽

Carolyn E. Mountford ◽

Adrienne J. Grant ◽

...

Keyword(s):

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Drug Resistant ◽

Wild Type ◽

Ovary Cells

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Faculty Opinions recommendation of Integrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2712967.2376067 ◽

2010 ◽

Author(s):

Myron Cybulsky ◽

Sharon Hyduk

Keyword(s):

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells

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Review of the current methods of Chinese Hamster Ovary (CHO) cells cultivation for production of therapeutic protein

Current Drug Discovery Technologies ◽

10.2174/1570163817666200312102137 ◽

2020 ◽

Vol 17 ◽

Cited By ~ 3

Author(s):

Shazid Md. Sharker ◽

Md. Atiqur Rahman

Keyword(s):

Chinese Hamster Ovary ◽

Cho Cells ◽

Mass Production ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Therapeutic Protein ◽

Specific Productivity ◽

Ovary Cells ◽

Further Development ◽

Interesting Area

Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein. The developments of cell lines are possible to upgrade specific productivity. As a result, it holds an interesting area for academic as well as industrial researchers around the world. This review will concentrate on the recent progress of the mammalian CHO cells culture technology and the future scope of further development for the mass-production of protein therapeutics.

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