scholarly journals Συσχέτιση των μεταβολών του ενδοθηλιακού γλυκοκάλυκα με τη στεφανιαία εφεδρεία ροής την αρτηριακή σκληρία (arterial stiffness) και τα ανακλώμενα κύματα της αορτής σε νεοδιαγνωσθέντες υπερτασικούς ασθενείς

2018 ◽  
Author(s):  
Αστρινός Βουμβουράκης
Keyword(s):  
Arterial Stiffness ◽  
Speckle Tracking ◽  
Boundary Region ◽  
Sidestream Darkfield ◽  
Darkfield Imaging

Σκοπός: Διερευνήσαμε τη συσχέτιση της βλάβης του ενδοθηλιακού γλυκοκάλυκα με την αρτηριακή σκληρία, τη δυσλειτουργία της στεφανιαίας μικροκυκλοφορίας και την εξασθένιση της μυοκαρδιακής παραμόρφωσης, σε νεοδιαγνωσθέντες υπερτασικούς ασθενείς χωρίς φαρμακευτική αγωγή.Μέθοδοι και αποτελέσματα: Σε 320 νεοδιαγνωσθέντες υπερτασικούς ασθενείς χωρίς φαρμακευτική αγωγή και σε 160 φυσιολογικά άτομα της ομάδας ελέγχου, μετρήσαμε: α) το perfused boundary region (PBR) στην υπογλώσσια αρτηριακή μικροκυκλοφορία, β) το δείκτη του πάχους του γλυκοκάλυκα, χρησιμοποιώντας Sidestream Darkfield Imaging, γ) τη στεφανιαία εφεδρεία ροής (CFR) με τη ηχωκαρδιογραφία Doppler, δ) τη συνολική επιμήκης παραμόρφωση (GLS) και το ρυθμό συνολικούς επιμήκους παραμόρφωσης (GLSr) με την ηχωκαρδιογραφική μέθοδο speckle tracking, ε) την καρωτιδική και μηριαία ταχύτητα παλμικού κύματος (PWV) και τη συστολική κεντρική αρτηριακή πίεση (cSBP. Συγκριτικά με τα φυσιολογικά άτομα, οι υπερτασικοί είχαν υψηλότερες τιμές του PBR, του PWV, της cSPB και χαμηλότερες τιμές του GLS και GLSr (p<0.05). Στους υπερτασικούς ασθενείς υπήρξε στενή συσχέτιση στο μειωμένο πάχος του ενδοθηλιακού γλυκοκάλυκα όπως εκτιμήθηκε με το αυξημένο PBR, την αυξημένη κεντρική συστολική αρτηριακή πίεση και την αυξημένη ταχύτητα παλμικού κύματος όπως και στη μείωση της στεφανιαίας εφεδρείας ροής (CFR) (p<0,05), την οριακή σχέση του PBR με τη συστολική αρτηριακή πίεση του ιατρείου (p=0,06) μετά από προσαρμογή της ηλικίας, του φύλλου, του δείκτη μάζας σώματος, του καπνίσματος, της μάζας της αριστερής κοιλίας, της καρδιακής συχνότητας ,της δυσλιπιδαιμίας και της συστολικής αρτηριακής πίεσης του ιατρείου.Το PBR είχε μία επιπρόσθετη αξία του πολυπαραγοντικού μοντέλου που περιλάμβανε το PWV, τη CFR και τη συστολική αρτηριακή πίεση του ιατρείου στην πρόβλεψη του παθολογικού GLS (x2=2.4 έναντι 3.8 μετά από την προσθήκη του PBR 5-25, p για αλλαγή=0,03). Συμπεράσματα: Ο ενδοθηλιακός γλυκοκάλυκας είναι παθολογικός στους νεοδιαγνωσθέντες υπερτασικούς ασθενείς. Αυτή η βλάβη σχετίζεται με την ανωμαλία των ελαστικών ιδιοτήτων της αορτής και την παθολογική λειτουργία της στεφανιαίας μικροκυκλοφορίας, που συμβάλλει στην εξασθένηση της επιμήκους παραμόρφωσης της αριστερής κοιλίας.

scholarly journals Two-dimensional speckle tracking of the abdominal aorta: a novel approach to evaluate arterial stiffness in patients with Turner syndrome

2019 ◽  
Vol 9 (S2) ◽  
pp. S228-S237 ◽  
Author(s):  
Felix Sebastian Oberhoffer ◽  
Hashim Abdul-Khaliq ◽  
Anna-Maria Jung ◽  
Tilman R. Rohrer ◽  
Mohamed Abd El Rahman
Keyword(s):  
Arterial Stiffness ◽  
Turner Syndrome ◽  
Abdominal Aorta ◽  
Speckle Tracking ◽  
Two Dimensional ◽  
Novel Approach

scholarly journals Assessment of left ventricular function and peripheral vascular arterial stiffness in patients with dipper and non-dipper hypertension

2017 ◽  
Vol 66 (2) ◽  
pp. 319-324 ◽  
Author(s):  
Yan Chen ◽  
Ju-Hua Liu ◽  
Zhe Zhen ◽  
Yuan Zuo ◽  
Qingshan Lin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
High Blood Pressure ◽  
Speckle Tracking ◽  
Systolic Function ◽  
Systolic Dysfunction ◽  
Multivariable Analysis ◽  
Strain Analysis ◽  
Left Ventricular ◽  
Increased Risk

A non-dipper pattern of high blood pressure is associated with increased risk of organ damage and cardiovascular disease in patients with hypertension. The aim of the study was to evaluate the left ventricular (LV) remodeling and function and arterial stiffness in a dipper/non-dipper pattern of high blood pressure in patients with hypertension. A total of 183 hypertensive patients with no history of adverse cardiovascular events were divided into two groups based on 24 hours ambulatory blood pressure monitoring (ABPM): 66 patients with a dipper pattern and 117 patients with non-dipper pattern. Detailed transthoracic echocardiogram was performed and analyzed with advance speckle tracking 3-orthogonal direction strain analysis to assess LV systolic function and tissue Doppler-derived E/E′ for LV diastolic function assessment. Cardio ankle vascular index (CAVI) was used to evaluate arterial stiffness. Compared with patients with dipper hypertension, those with non-dipper hypertension had increased LV mass index, higher prevalence of eccentric and concentric LV hypertrophy, more impaired LV diastolic and systolic function and peripheral arterial stiffness. Multivariable analysis revealed that a non-dipper pattern was independently associated with LV systolic dysfunction evaluated by speckle tracking-derived strain analysis. In conclusion, a non-dipper pattern of hypertension is an independent risk factor for LV systolic dysfunction. Treatment that could reverse this non-dipper pattern may reduce cardiac damage in these patients.

scholarly journals P673Improvement of arterial stiffness and myocardial deformation in patients with poorly controlled diabetes mellitus type 2 after optimization of antidiabetic medicationP674Clinical presentation, echocardiographic findings and complications in patients with typical and atypical form of takotsubo cardiomyopathyP675Left ventricular mass/end-diastolic volume ratio with tridimensional echocardiography in newly-diagnosed hypertensive patients: which relation between left ventricular geometry and stroke volume?P676Endothelial dysfunction: the link between arterial hypertension, diabetes mellitus and heart diseaseP677Dynamic of changes of arterial stiffness evaluated by cardio-ankle vascular index(CAVI) during the growth and development of children and adolescentsP678Peripheral arterial stiffness in pulmonary hypertension and pulmonary embolism: assessment with cardio ankle vascular index, noninvasive markers of vascular diseaseP679Early detection and prediction of CHOP-induced cardiotoxicity in nonHodgkin lymphoma by 4D echocardiography, vascular ultrasound, and cardiac biomarkersP680Right ventricular remodeling in children engaged in endurance sports: a longitudinal study in preadolescent athletesP681Electrocardiographic criteria for atria enlargement are not useful in the evaluation of junior high-dynamic high-static athletesP682Prognostic value of right ventricle, pulmonary arterial pressure and biomarkers in patients with acute heart failure: one year follow upP683One-point carotid stiffness parameters by echo-tracking method in a wide-age range of healthy population. A single center experienceP684Role of bidimensional speckle tracking longitudinal strain in the evaluation of right and left ventricular function in adult patients with transposition of the great arteriesP685Interfaces between FBN1 gene polymorphism and biomechanical parameters estimated by speckle-tracking echocardiography of dilative pathology of ascending aorta P686Layer-specific speckle tracking analysis for the detection of coronary artery disease during dipyridamole stress echoP687Stress echo in Italy: state-of-the art 2015P688The declining frequency of Inducible myocardial ischemia during stress echocardiography over 27 consecutive years (1983-2009)P689Global longitudinal strain can unmask inducible myocardial ischemia at submaximal heart rate during dobutamine stress echocardiography.P690Low risk syntax score predicted by wall motion score index during dobutamine stress echocardiographyP691Outdoor stress echo by lung ultrasound for subclinical detection of high altitude pulmonary edema with B-linesP692Predictors and consequences of infective endocarditis with perivalvular extension - a subgroup with worse short and medium-term prognosisP693Analysis of left atrial auricle morphology and function to detect considerable risk factors regarding the prevention of strokeP694LAA closure - does size really matter?P695Real assessment of mitral regurgitation by three-dimensional transesophageal echocardiographyP696Myocardial contrast dobutamine stress echocardiography for detection of coronary artery disease

2016 ◽  
Vol 17 (suppl 2) ◽  
pp. ii136-ii143
Author(s):  
I. Ikonomidis ◽  
M. Budnik ◽  
M. Lembo ◽  
A-M Vintila ◽  
T. Jurko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Arterial Stiffness ◽  
Speckle Tracking ◽  
Stress Echocardiography ◽  
Longitudinal Strain ◽  
Dobutamine Stress ◽  
Left Ventricular ◽  
Artery Disease

scholarly journals Ambulatory arterial stiffness index is associated with impaired left atrial mechanical functions in hypertensive diabetic patients: A speckle tracking study

2015 ◽  
Vol 15 (10) ◽  
pp. 807-813 ◽  
Author(s):  
Ezgi Kalaycioglu ◽  
Tayyar Gokdeniz ◽  
Ahmet Cagri Aykan ◽  
Engin Hatem ◽  
Ozan Mustafa Gursoy ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Stiffness Index ◽  
Diabetic Patients ◽  
Arterial Stiffness Index

Feasibility of two-dimensional speckle tracking in evaluation of arterial stiffness: Comparison with pulse wave velocity and conventional sonographic markers of atherosclerosis

Vascular ◽  
2017 ◽  
Vol 26 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Michał Podgórski ◽  
Piotr Grzelak ◽  
Magdalena Kaczmarska ◽  
Michał Polguj ◽  
Maciej Łukaszewski ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Speckle Tracking ◽  
Pulse Wave ◽  
Potential Candidate ◽  
Two Dimensional ◽  
Early Marker ◽  
Cardiovascular Morbidity And Mortality ◽  
Wall Stiffness

Objective Arterial stiffening is an early marker of atherosclerosis that has a prognostic value for cardiovascular morbidity and mortality. Although many markers of arterial hardening have been proposed, the search is on for newer, more user-friendly and reliable surrogates. One such potential candidate has emerged from cardiology, the speckle-tracking technique. The aim of this study was to evaluate the feasibility of the two-dimensional speckle tracking for the evaluation of arterial wall stiffness in comparison with standard stiffness parameters. Methods Carotid ultrasound and applanation tonometry were performed in 188 patients with no cardiovascular risk factors. The following parameters were then evaluated: the intima-media complex thickness, distensibility coefficient, β-stiffness index, circumferential strain/strain rate, and pulse wave velocity and augmentation index. These variables were compared with each other and with patient age, and their reliability was assessed with Bland-Altman plots. Results Strain parameters derived from two-dimensional speckle tracking and intima-media complex thickness correlated better with age and pulse wave velocity than standard makers of arterial stiffness. Moreover, the reliability of these measurements was significantly higher than conventional surrogates. Conclusions Two-dimensional speckle tracing is a reliable method for the evaluation of arterial stiffness. Therefore, together with intima-media complex thickness measurement, it offers great potential in clinical practice as an early marker of atherosclerosis.

The effects of empagliflozin on arterial stiffness, endothelial function and ventriculoarterial coupling in type 2 diabetes mellitus: 1 year follow up

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
I Ikonomidis ◽  
J Thymis ◽  
G Pavlidis ◽  
D Birba ◽  
A Kalogeris ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Boundary Region ◽  
Endothelial Glycocalyx ◽  
Insulin Group ◽  
Central Systolic Blood Pressure

Abstract Introduction Sodium glucose cotransporters inhibitors (SGLT2i) are currently used in the treatment of patients with type 2 diabetes mellitus (T2DM) who pose high cardiovascular risk. However their effects on arterial stiffness, endothelial function and ventriculoarterial coupling have not been described. Methods We recruited 120 patients with T2DM. They received either the SGLT2i empagliflozin (n=60) or insulin (n=60). We measured at baseline and after 1 year of treatment: 1) Perfused Boundary Region (PBR 5–25μm) to evaluate endothelial glycocalyx integrity via Glycocheck, 2) Pulse wave Velocity (PWVc-f), 3)central systolic blood pressure (cSBP), 4) central Pulse Pressure (cPP) via Complior,5) the ratio PWV/GLS by echocardiography to assess ventriculoarterial coupling (VA coupling). Results The patients were matched for age, gender, smoking, hypertension and hyperlipidemia (p=NS). Hemoglobin A1c was deteriorated in both groups (8.1% vs 8.2%, p=NS). The baseline measurements of aforementioned markers did not differ between the 2 groups (p=NS). PWV was correlated with cSBP (r=0.4.p&lt;0.05) and cPP (r=0.35, p&lt;0.05) for all participants at baseline. After 1 year of treatment both groups achieved significant reduction of HbA1c. Patients treated with insulin showed an increase of PWV in contrary with empagliflogin group (11.4±0.5 to 12.6±0.4 vs 11.7±0.5 to 10.9±0.4, correspondingly, p&lt;0.05). cSBP declined considerably in empagliflozin group (135±10 to 129±10 vs 134±9 to 136±9 respectively, p&lt;0.05) and cPP remained approximately steady (47±8 to 48±8 vs 49±6 to 55±6 respectively, p&lt;0.05) compared with insulin group. PBR dropped in SGLT2i group (2.20±0.2 to 1.98±0.2, p&lt;0.05) whereas PBR fluctuated at the same level in insulin group (2.18±0.2 to 2.15±0.3, p=NS).PWV/GLS fell in both groups but the reduction was more prominent in empagliflozin group (−0.72±0.1 to −0.67±0.1 vs −0.72±0.1 to −0.60±0.1 respectively, p&lt;0.05). Conclusion 1 year treatment with empagliflozin resulted in improved markers of arterial stiffness, ventriculoarterial coupling and endothelial function, independently of glycemic control. Funding Acknowledgement Type of funding source: None

Subclinical arterial stiffness in young children after Kawasaki disease

2013 ◽  
Vol 24 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Masato Oguri ◽  
Tsuneyuki Nakamura ◽  
Keita Tamanuki ◽  
Chisato Akita ◽  
Chika Kitaoka ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Arterial Stiffness ◽  
Young Children ◽  
Strain Rate ◽  
Speckle Tracking ◽  
Regions Of Interest ◽  
Systolic Strain ◽  
Time To Peak ◽  
Peak Systolic Strain ◽  
History Of

AbstractBackgroundRecent studies have revealed that atherosclerosis progresses faster than expected in young adults with a history of Kawasaki disease. However, it is unclear as to when these arterial changes become measurable. In this study, we evaluated subclinical arterial stiffness in young children with a history of Kawasaki disease using two-dimensional ultrasound speckle tracking.MethodsA total of 75 children with a history of Kawasaki disease (mean age, 8.2 ± 2.8 years) and 50 healthy controls (mean age 8.3 ± 3.5 years) were included. The two regions of interest for speckle tracking were manually positioned at the anterior and posterior carotid arterial wall using a Philips iE33 (Philips Medical Systems, Bothell, WA, USA). The peak systolic strain, time to peak systolic strain, early systolic strain rate, and late systolic strain rate were continuously monitored between the two regions of interest. Furthermore, the intimal-medial thickness, stiffness β, and pressure-elastic modulus, as conventional measures of arterial stiffness, were concurrently obtained.ResultsThe peak systolic strain and late systolic strain rate differed significantly between the patients with Kawasaki disease and controls (6.69% versus 8.60%, p < 0.01, and −0.28/second versus −0.51/second, p < 0.0001, respectively). There was no difference in the time to peak systolic strain, early systolic strain rate, and conventional measures.ConclusionsThe arteries of patients with Kawasaki disease appear to develop mild sclerotic changes shortly after the onset of the disease.

scholarly journals Reproducibility of sublingual microcirculation parameters obtained from sidestream darkfield imaging

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213175 ◽  
Author(s):  
Luca Valerio ◽  
Ron J. Peters ◽  
Aeilko H. Zwinderman ◽  
Sara-Joan Pinto-Sietsma
Keyword(s):  
Sublingual Microcirculation ◽  
Sidestream Darkfield ◽  
Darkfield Imaging
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