scholarly journals Επίδραση της λαπαρασκοπικής χολοκυστεκτομής στον άξονα αυξητικής ορμόνης (GH-IGF'S) και στρες (stress)

2016 ◽  
Author(s):  
Θεμιστοκλής Φλώρος
Keyword(s):  
Λαπαροσκοπική Χολοκυστεκτομή ◽  
Post Hoc ◽  
Igfbp 3

ΣΚΟΠΟΣ: Είναι γνωστό ότι η συμβατική χειρουργική επέμβαση οδηγεί σε επιζήμιες ανοσολογικές και καταβολικές αντιδράσεις, με αποτέλεσμα να αυξάνεται το ενδιαφέρον για την επίδραση των ελάχιστα επεμβατικών τεχνικών στην μετεγχειρητική ενδοκρινική και ανοσολογική λειτουργία. Στόχος αυτής της προοπτικής μελέτης ήταν η αξιολόγηση του άξονα αυξητικής ορμόνης (GH) / ινσουλινοειδούς αυξητικού παράγοντα 1 (IGF-1) / IGF-3 (IGFBP-3) και οξείας φάσης (ιντερλευκίνη-6, , και C-αντιδρώσα πρωτεΐνη, CRP) σε ασθενείς που υποβλήθηκαν σε λαπαροσκοπική χολοκυστοεκτομή.ΣΧΕΔΙΑΣΜΟΣ: Είκοσι εννέα ασθενείς (16 γυναίκες, 13 άνδρες, ηλικία: 58 + 8 έτη) με ιστορικό απλής συμπτωματικής χολολιθίασης συμμετείχαν στη μελέτη. Τα δείγματα αίματος συλλέχθηκαν πριν και στις 24 ώρες και 48 ώρες μετά τη λαπαροσκοπική χολοκυστεκτομή. Οι συγκεντρώσεις ορού των GH, IGF-1, IGFBP-3 και IL-6 προσδιορίστηκαν με πρότυπη ανοσοπροσροφητική δοκιμασία ενζυμικού συνδέσμου σάντουιτς (ELISA), ενώ η CRP μετρήθηκε με νεφελομετρία. H repeated ANOVA και η post-hoc ανάλυση Tukey χρησιμοποιήθηκαν για την αξιολόγηση των αλλαγών στις μετρήσεις του ορού.ΑΠΟΤΕΛΕΣΜΑΤΑ: Η λαπαροσκοπική χολοκυστοεκτομή είχε ως αποτέλεσμα σημαντική μετεγχειρητική αύξηση των επιπέδων κυκλοφορίας της IL-6 (p = 0,031), που είναι η κύρια κυτοκίνη υπεύθυνη για την επαγωγή της οξείας φλεγμονώδους απόκρισης και της CRP οξείας φάσης πρωτεΐνης (ρ = 0,005). Παρατηρήθηκε επίσης σημαντική αύξηση των επιπέδων GH σε 24 ώρες (p = 0,034) και μείωση του IGF-1 και στις δύο μετεγχειρητικές ημέρες (p = 0,045, 0,044), ενώ δεν παρατηρήθηκαν αλλαγές στα επίπεδα IGFBP-3. Σημαντικές συσχετίσεις αποκαλύφθηκαν μεταξύ των μετεγχειρητικών επιπέδων των πρωτεϊνών οξείας φάσης και των ορμονών του άξονα ανάπτυξης (ρ <0,05-0,001).ΣΥΜΠΕΡΑΣΜΑΤΑ: Τα ευρήματά μας υποδηλώνουν ότι η λαπαροσκοπική χολοκυστοεκτομή προκαλεί οξεία φάση ενδοκρινικών και ανοσολογικών αποκρίσεων. Αυτές οι αλλαγές μπορεί να αντιπροσωπεύουν κατάσταση συστημικής φλεγμονής και αντίστασης GH, συμβατή με πιθανά αντι-αναβολικά ή καταβολικά επαγόμενα από κυτοκίνη αποτελέσματα ακόμη και μετά από αυτήν την ελάχιστα επεμβατική χολοκυστεκτομή.

scholarly journals SUN-LB61 Differential and Opposite Regulation of Acid Labile Subunit (ALS) Versus Insulin-Like Growth Factor I (IGF-I) by Oral Estrogens in Premenopausal Women

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Katharina Schilbach ◽  
Michael Haenelt ◽  
Shiva Sophia Nicolay ◽  
Laura Schwerdt ◽  
Rita Schwaiger ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Negative Correlation ◽  
Premenopausal Women ◽  
Oral Contraception ◽  
Limit Of Quantification ◽  
Igf I ◽  
Igf Binding ◽  
Post Hoc ◽  
The Impact ◽  
Igfbp 3

Abstract Background: The impact of estrogens (E2) on the growth hormone (GH)/IGF-I axis is known to depend on route of administration: While oral E2 increases GH and decreases IGF-I, transdermal E2 has only limited or no effect. However, data concerning the impact of E2 on IGF binding protein 3 (IGFBP 3) and ALS are less clear. One study in girls demonstrated higher ALS with oral E2, while the opposite was suggested for postmenopausal women. No data are available for healthy premenopausal women.Methods: We measured IGF-I, IGFBP 3 and ALS in fasted healthy adults (93 males (M), 35 premenopausal women without E2-containing oral contraception (FPRE), 37 premenopausal women with E2-containing oral contraception (FPREOC) and 34 postmenopausal women (FPOST)). IGF-I and IGFBP 3 were measured using the IDS-iSYS chemiluminescence immunoassay, and ALS by an in-house immunofluorometric assay (limit of quantification (LoQ) &lt; 50 mU/ml, range 50 - 4000 mU/mL).Results: Median age (range) was 33 (20 - 76), 28 (20 - 44), 24 (21 - 36) and 56 (49 - 70) years for M, FPRE, FPREOC and FPOST, respectively. As expected, IGF-I was lower in FPREOC compared to FPRE (median IGF-I xULN (IQR) 0.56 (0.45 - 0.73) and 0.72 (0.63 – 0.80), P = 0.0017, Kruskal-Wallis). ALS was significantly higher in FPREOC compared to all other groups (mean ALS in M, FPRE, FPREOC and FPOST: 636, 708, 861 and 648 mU/mL, respectively, ANOVA P &lt; 0.0001, Dunnett’s post-hoc test: M vs FPREOC: P &lt; 0.0001, FPRE vs FPREOC: P = 0.0007, FPOST vs FPREOC: P &lt; 0.0001). IGFBP 3 was not different in females with and without oral E2 (median IGFBP 3 xULN (IQR) FPREOC vs FPRE: 0.62 (0.54 - 0.67) vs 0.60 (0.49 – 0.76), Kruskal-Wallis P = 0.295, Dunn’s post-hoc test: P &gt; 0.9999). This was also true between all other groups (Dunn’s post-hoc test: P ≥ 0.4). In our adult cohort, ALS exhibited negative correlation with age (Pearson r = -0.282, P = 0.0003), similar to IGF-I and IGFBP 3. While IGF-I exhibited a moderate negative correlation to BMI (Pearson r = -0.25, P = 0.0013), IGFBP 3 and ALS were not significantly related to BMI.Conclusion: While IGF-I, IGFBP 3 and ALS all are known to be secreted in response to GH, and IGF-I and ALS are assumed to be produced by the same cells in the liver (hepatocytes), the three GH dependent biomarkers appear to be differently regulated by metabolic factors and oral E2. Only IGF-I has some modest association with BMI. Oral E2 is associated with reduced IGF-I, unchanged IGFBP 3 but increased ALS. While the mechanism behind the differential regulation remains to be uncovered, E2 therapy must be taken into account when interpreting IGF-I and ALS concentrations.

The Link Between Verbal Short-Term Memory and Anomia Treatment Gains

2019 ◽  
Vol 28 (3) ◽  
pp. 1039-1052
Author(s):  
Reva M. Zimmerman ◽  
JoAnn P. Silkes ◽  
Diane L. Kendall ◽  
Irene Minkina
Keyword(s):  
Short Term Memory ◽  
Controlled Trial ◽  
Treatment Success ◽  
Linear Regression Models ◽  
Language Performance ◽  
Short Term ◽  
Term Memory ◽  
Treatment Gains ◽  
Post Hoc

Purpose A significant relationship between verbal short-term memory (STM) and language performance in people with aphasia has been found across studies. However, very few studies have examined the predictive value of verbal STM in treatment outcomes. This study aims to determine if verbal STM can be used as a predictor of treatment success. Method Retrospective data from 25 people with aphasia in a larger randomized controlled trial of phonomotor treatment were analyzed. Digit and word spans from immediately pretreatment were run in multiple linear regression models to determine whether they predict magnitude of change from pre- to posttreatment and follow-up naming accuracy. Pretreatment, immediately posttreatment, and 3 months posttreatment digit and word span scores were compared to determine if they changed following a novel treatment approach. Results Verbal STM, as measured by digit and word spans, did not predict magnitude of change in naming accuracy from pre- to posttreatment nor from pretreatment to 3 months posttreatment. Furthermore, digit and word spans did not change from pre- to posttreatment or from pretreatment to 3 months posttreatment in the overall analysis. A post hoc analysis revealed that only the less impaired group showed significant changes in word span scores from pretreatment to 3 months posttreatment. Discussion The results suggest that digit and word spans do not predict treatment gains. In a less severe subsample of participants, digit and word span scores can change following phonomotor treatment; however, the overall results suggest that span scores may not change significantly. The implications of these findings are discussed within the broader purview of theoretical and empirical associations between aphasic language and verbal STM processing.

Abstract #295 GLP-1 Receptor Agonists and Death From Any Cause in Elderly Patients with Type 2 Diabetes Mellitus: A Post-Hoc Analysis

2018 ◽  
Vol 24 ◽  
pp. 80-81
Author(s):  
Konstantinos Toulis ◽  
Krishna Gokhale ◽  
G. Neil Thomas ◽  
Wasim Hanif ◽  
Krishnarajah Nirantharakumar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Elderly Patients ◽  
Post Hoc Analysis ◽  
Receptor Agonists ◽  
Post Hoc

Abstract #245 Efficacy and Safety of Semaglutide in Elderly Subjects with Type 2 Diabetes: A Post Hoc Analysis of the Sustain 7 Trial

2018 ◽  
Vol 24 ◽  
pp. 51-52
Author(s):  
Vanita Aroda ◽  
Danny Sugimoto ◽  
David Trachtenbarg ◽  
Mark Warren ◽  
Gurudutt Nayak ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Elderly Subjects ◽  
Efficacy And Safety ◽  
Post Hoc Analysis ◽  
Post Hoc

Zwangsstörung, frontostriatales System und Beeinflussung des serotonergen Systems

2000 ◽  
Vol 28 (1) ◽  
pp. 35-44 ◽  
Author(s):  
L. Baving ◽  
M.H. Schmidt
Keyword(s):  
Kardiale Nebenwirkungen ◽  
Post Hoc

Zusammenfassung:Fragestellung: Forschungsschwerpunkte der letzten Jahre bei der Zwangsstörung waren zum einen die Beteiligung des frontostriatalen Systems an der Pathophysiologie, zum anderen die Wirkungsweise und Effektivität von Serotonin-Wiederaufnahmehemmern, welche im frontostriatalen System ihre spezifische Wirksamkeit bei der Zwangsstörung entfalten. Die Behandlungsverläufe jugendlicher, stationär behandelter Zwangspatienten wurden hinsichtlich der verwendeten Medikamente und ihrer Auswirkungen auf den Behandlungsverlauf untersucht. Methodik: Die Akten aller seit 1. 1. 1990 in der Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters in Mannheim zur stationären Aufnahme gekommenen Zwangspatienten wurden ausgewertet bezüglich Medikations-, Verlaufs- und Outcomeparametern. Ergebnisse: 5 Patienten brachen die Behandlung ab, 5 Patienten erhielten keine Medikation, 8 bekamen Sulpirid, 10 Clomipramin, 3 Fluvoxamin. Die mittlere Dauer des stationären Aufenthaltes war für die beiden mit Sulpirid und Clomipramin medizierten Gruppen länger als für die unmedizierte Gruppe, jedoch für die beiden Gruppen mit medikamentöser Behandlung fast gleich. Der Behandlungserfolg für die Zwangssymptomatik wurde in den beiden medizierten Gruppen als höher bewertet als in der nicht-medizierten Gruppe. Unter Sulpirid zeigten sich Gewichtszunahme, Müdigkeit und Prolaktinerhöhung, unter Clomipramin bei der Hälfte der Patienten kardiale Nebenwirkungen. Schlußfolgerungen: In dieser kleinen, nicht randomisiert und nicht unter doppelt-blind-Bedingungen medizierten Stichprobe zeigt sich in einer Post-hoc-Analyse keine unterschiedliche Effektivität von Clomipramin und Sulpirid. Die unter Clomipramin auftretenden Nebenwirkungen lassen an einen häufigeren Einsatz von selektiven Serotonin-Wiederaufnahmehemmern zur Steigerung der Medikamentencompliance denken.

Hostile and Hardened? An Experimental Study on (De-)Sensitization to Violence and Suffering Through Playing Video Games

2008 ◽  
Vol 67 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Frithjof Staude-Müller ◽  
Thomas Bliesener ◽  
Stefanie Luthman
Keyword(s):  
Video Games ◽  
Emotional Responses ◽  
Physiological Measurement ◽  
Different Types ◽  
Downward Spiral ◽  
Spiral Model ◽  
Post Hoc ◽  
Game Violence ◽  
First Person Shooter ◽  
Physiological Reactions

This study tests whether playing violent video games leads to desensitization and increased cardiovascular responding. In a laboratory experiment, 42 men spent 20 min playing either a high- or low-violence version of a “first-person shooter” game. Arousal (heart rate, respiration rate) was measured continuously. After playing the game, emotional responses to aversive and aggressive stimuli - pictures from Lang, Bradley, and Cuthbert’s (1999) International Affective Picture System - were assessed with self-ratings and physiological measurement (skin conductance). Results showed no differences in the judgments of emotional responses to the stimuli. However, different effects of game violence emerged in the physiological reactions to the different types of stimulus material. Participants in the high-violence condition showed significantly weaker reactions (desensitization) to aversive stimuli and reacted significantly more strongly (sensitization) to aggressive cues. No support was found for the arousal hypothesis. Post-hoc analyses are used to discuss possible moderating influences of gaming experience and player’s trait aggressiveness in terms of the General Aggression Model ( Anderson & Bushman, 2001 ) and the Downward Spiral Model ( Slater, Henry, Swaim, & Anderson, 2003 ).

Response-Specific Scalp Distributions in Deception Detection and ERP Correlates of Psychopathic Personality Traits

2004 ◽  
Vol 18 (1) ◽  
pp. 13-26 ◽  
Author(s):  
Antoinette R. Miller ◽  
J. Peter Rosenfeld
Keyword(s):  
Deception Detection ◽  
Event Related Potential ◽  
Psychopathic Personality ◽  
P300 Amplitude ◽  
Group Differences ◽  
Post Hoc Analysis ◽  
P300 Component ◽  
Psychopathic Personality Inventory ◽  
Post Hoc ◽  
First Time

Abstract University students were screened using items from the Psychopathic Personality Inventory and divided into high (n = 13) and low (n = 11) Psychopathic Personality Trait (PPT) groups. The P300 component of the event-related potential (ERP) was recorded as each group completed a two-block autobiographical oddball task, responding honestly during the first (Phone) block, in which oddball items were participants' home phone numbers, and then feigning amnesia in response to approximately 50% of items in the second (Birthday) block in which oddball items were participants' birthdates. Bootstrapping of peak-to-peak amplitudes correctly identified 100% of low PPT and 92% of high PPT participants as having intact recognition. Both groups demonstrated malingering-related P300 amplitude reduction. For the first time, P300 amplitude and topography differences were observed between honest and deceptive responses to Birthday items. No main between-group P300 effects resulted. Post-hoc analysis revealed between-group differences in a frontally located post-P300 component. Honest responses were associated with late frontal amplitudes larger than deceptive responses at frontal sites in the low PPT group only.

Post hoc scale construction

2005 ◽  
Author(s):  
Kristin Kosbab ◽  
Frank Bernieri ◽  
Andrew Geers ◽  
Paul Weiland ◽  
Brad Okdie ◽  
...  
Keyword(s):  
Scale Construction ◽  
Post Hoc

Post Hoc Investigation of Factor Mixture Models

2007 ◽  
Author(s):  
Danielle L. Cisler ◽  
Gitta H. Lubke
Keyword(s):  
Mixture Models ◽  
Post Hoc
Sign in / Sign up

Export Citation Format

Share Document