scholarly journals Η επίδραση της υπολιπιδαιμικής αγωγής - είτε με αναστολείς της σύνθεσης της χοληστερόλης είτε με αναστολείς της απορρόφησης της χοληστερόλης - στους δείκτες φλεγμονής και θρομβωτικούς και ιστικούς παράγοντες σε ασθενείς με δυσλιπιδαιμία

2009 ◽  
Author(s):  
Παναγιώτα Κωστάκου
Keyword(s):  
High Density Lipoprotein ◽  
Tissue Factor ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Von Willebrand

Οι στατίνες έχουν ευνοϊκή επίδραση στο λιπιδαιμικό προφίλ, μειώνουν την ολική θνησιμότητα και παρουσιάζουν επίσης πολλές πλειοτροπικές δράσεις. Ο σκοπός της παρούσας εργασίας ήταν να προσδιοριστούν και να συγκριθούν οι πλειοτροπικές δράσεις ενός αναστολέα της σύνθεσης της χοληστερόλης και συγκεκριμένα της σιμβαστατίνης (Σ) και ενός αναστολέα της απορρόφησης της χοληστερόλης και συγκεκριμένα της εζετιμίμπης (Ε), σε ασθενείς με δυσλιπιδαιμία. Σε 44 ασθενείς (24 άνδρες και 20 μεταεμμηνοπαυσιακές γυναίκες) με χαμηλής πυκνότητας λιποπρωτεΐνη (low density lipoprotein-LDL) > 130 mg/dl ή LDL > 100 mg/dl σε ασθενείς με στεφανιαία νόσο ή ανάλογο αυτής, χορηγήθηκαν 10 mg Σ (η=21) ημερησίως ή 10 mg E (η=23) ημερησίως. Ελήφθησαν δείγματα αίματος στην αρχή και τρεις μήνες μετά την έναρξη της θεραπείας. Σε όλα τα δείγματα μετρήθηκαν τα επίπεδα της ολικής χοληστερόλης, των τριγλυκεριδίων, της υψηλής σε πυκνότητα λιποπρωτεΐνης (high density lipoprotein-HDL), της LDL, της απολιποπρωτεΐνης [apolipoprotein (apo)] A, της apoB, της λιποπρωτεΐνης [Lipoprotein (lp)] (a), της ομοκυστεΐνης , του ‘tissue factor’ (TF), του παράγοντα von Willebrand (vW) και της C αντιδρώσας πρωτεΐνης (C-reactive protein, CRP). Οι αρχικές τιμές των λιπιδίων και των αιματολογικών παραμέτρων ανάμεσα στις δύο ομάδες ήταν παρόμοιες. Η Σ και η Ε μείωσαν την ολική χοληστερόλη (262 mg/dl σε 189 mg/dl, p<0,001 και 268 mg/dl σε 220 mg/dl, p=0,001, αντίστοιχα, την LDL (177 mg/dl σε 114 mg/dl, p<0,001 και 196 mg/dl σε 146 mg/dl, p<0,001, αντίστοιχα). Επίσης, η Σ ελάττωσε τα επίπεδα της apoB (125 mg/dl σε 93 mg/dl, p<0,001). Κανένα από τα φάρμακα δεν επηρέασε τις συγκεντρώσεις της lp(a), του TF, του vW και της ομοκυστεϊνης. Και τα δύο φάρμακα βελτίωσαν το λιπιδαιμικό προφίλ των ασθενών και τα επίπεδα της CRP. Παρόλ’ αυτά, δε διαπιστώθηκε καμία επίδραση στους TF και vW. Τα αποτελέσματά μας δεν υποδεικνύουν κάποια επιπρόσθετη πλειοτροπική αντιφλεγμονώδη δράση των στατινών πέραν της μείωσης της ολικής και της LDL χοληστερόλης.

scholarly journals Alterations of pancreatic functions and lipid profiles in dairy cows with left displacement of the abomasum

2019 ◽  
Vol 64 (No. 5) ◽  
pp. 204-208
Author(s):  
Z Ismail ◽  
AM Al-Majali ◽  
O Al-Rawashdeh ◽  
M Daradka ◽  
M Mohaffel
Keyword(s):  
High Density Lipoprotein ◽  
Dairy Cows ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Reactive Protein

The objectives of this study were to determine the serum activities of the pancreatic enzymes amylase, lipase, trypsinogen 1 and trypsinogen 2, serum concentrations of total cholesterol, high density lipoprotein, low-density lipoprotein and triglycerides and serum inflammatory indicators, namely C-reactive protein and procalcitonin, in Holstein-Friesian dairy cows with left displacement of the abomasum (LDA). A total of 60 cows (30 LDA-affected and 30 healthy) were included in the study. Laboratory analyses were performed using commercially available ELISA kits and chemical reagents according to the manufacturers’ recommendations. There was a significant increase (P ≤ 0.05) in the activities of lipase, trypsinogen 1 and trypsinogen 2 in LDA-affected cows compared to healthy cows. Amylase concentrations, however, remained unchanged. The serum concentrations of total cholesterol and high-density lipoprotein were significantly (P ≤ 0.05) increased in LDA-affected cows while the concentrations of low-density lipoprotein and triglycerides were significantly (P ≤ 0.05) decreased compared to healthy cows. Procalcitonin and C-reactive protein concentrations were significantly (P ≤ 0.05) increased in LDA-affected cows compared to healthy cows. This study indicates that displacement of the abomasum may be associated with significant pathological effects in the pancreas that may affect cows in the post-operative period.

scholarly journals Relationship between C-reactive protein and features of the metabolic syndrome in military pilots in the Serbia and Montenegro

2005 ◽  
Vol 62 (11) ◽  
pp. 811-819
Author(s):  
Aleksandra Jovelic ◽  
Goran Radjen ◽  
Stojan Jovelic ◽  
Marica Markovic
Keyword(s):  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
C Reactive Protein ◽  
Low Density Lipoprotein Cholesterol ◽  
Reactive Protein

Background/Aim. C-reactive protein is an independent predictor of the risk of cardiovascular events and diabetes mellitus in apparently healthy men. The relationship between C-reactive protein and the features of metabolic syndrome has not been fully elucidated. To assess the cross-sectional relationship between C-reactive protein and the features of metabolic syndrome in healthy people. Methods. We studied 161 military pilots (agee, 40?6 years) free of cardiovascular disease, diabetes mellitus and active inflammation on their regular annual medical control. Age, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, fasting glucose, glycosylated hemoglobin, blood pressure, smoking habit, waist circumference and body mass index were evaluated. Plasma C-reactive protein was measured by the immunonephelometry (Dade Behring) method. Metabolic syndrome was defined according to the National Cholesterol Education Program Expert Panel. Results. The mean C-reactive protein concentrations in the subjects grouped according to the presence of 0, 1, 2 and 3 or more features of the metabolic syndrome were 1.11, 1.89, 1.72 and 2.22 mg/L, respectively (p = 0.023) with a statistically, significant difference between those with 3, and without metabolic syndrome (p = 0.01). In the simple regression analyses C-reactive protein did not correlate with the total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, body mass index and blood pressure (p > 0.05). In the multiple regression analysis, waist circumference (? = 0.411, p = 0.000), triglycerides to high density lipoprotein cholesterol ratio (? = 0.774, p = 0.000), smoking habit (? = 0.236, p = 0.003) and triglycerides (? = 0.471, p = 0.027) were independent predictors of C-reactive protein. Conclusions. Our results suggested a cross-sectional independent correlation between the examined cardiovascular risk factors as the predominant features of metabolic syndrome and C-reactive protein in the group of apparently healthy subjects. The lack of correlation of C-reactive protein with the total cholesterol and low density lipoprotein cholesterol in our study may suggest their different role in the process of atherosclerosis and the possibility to determine C-reactive protein in order to identify high-risk subjects not identified with cholesterol screening.

scholarly journals Profil Lipid, Peroksidasi Lipid, dan Status Inflamatif Wanita Penderita Sindrom Metabolik

2011 ◽  
Vol 5 (5) ◽  
pp. 212
Author(s):  
Hery Winarsi ◽  
Siwi P.M. Wijayanti ◽  
Agus Purwanto
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
C Reactive Protein ◽  
Reactive Protein

Prevalensi sindrom metabolik (SM) di Indonesia (13,13%) tergolong tinggi dengan kecenderungan terus meningkat. Salah satu akibat SM adalah disfungsi endotel, sebagai awal penyakit kardiovaskuler yang diinduksi oleh stres oksidatif dan inflamatif. Penelitian ini bertujuan untuk mengeksplorasiprofil lipid, peroksidasi lipid, dan marker inflamasi pada wanita penderita SM di Purwokerto. Sebanyak 30 wanita dengan kadar gula darah diatas normal, obesitas body mass index (BMI) > 25 kg/m2, dan berusia 40-65 tahun dilibatkan sebagai responden yang dipilih melalui survei di PoliklinikPenyakit Dalam Rumah Sakit Margono Soekarjo. Kadar kolesterol total, trigliserida, high density lipoprotein, low density lipoprotein, malondialdehid, dan plasma C-reactive protein ditentukan dalam darah responden yang mempunyai kadar gula sewaktu > 200 mg/dL. Ditemukan bahwa wanitadengan SM rata-rata berumur 50,4 tahun; BMI 31,89 kg/m2; kadar gula darah 219,4 mg/dL; kolesterol total 216,73 mg/dL; trigliserida 218,13 mg/dL; HDL 46,59 mg/dL; LDL 146,27 mg/dL; MDA 2943,4 pmol/mL; C-RP 7,62 mg/L; dan tekanan darah 153/103 mmHg. Hasil ini menunjukkan bahwapenderita SM mengalami dislipidemia disertai dengan status antioksidan rendah dan inflamasi.Kata kunci: Wanita sindrom metabolik, profil lipid, lipid peroksida, malondialdehid, C-reactive proteinAbstractPrevalence of metabolic syndrome (MS) in Indonesia (13,13%) is high and tends to increase. One of the consequences of MS is endothelial dysfunction leading to cardiovascular disease which is inducted by oxidative stressand inflammation. The aim of the present research is to explore lipid profile, lipid peroxidation, and inflammatory marker level on metabolic syndrome women in Purwokerto. Thirty women with blood glucose level greater than normal, body mass index (BMI) > 25 kg/m2, 40-65 years of age were recruited as respondent through selection by a survey in Internal Medicine Polyclinic of Margono Soekarjo Hospital in Purwokerto. In respondents with blood glucose level > 200 mg/dL, total blood cholesterol level, high density lipoprotein, low density lipoprotein, malondialdehid, and plasma C-reactive protein were determined. It was found that the MS women were 50,4 years of age; BMI 31,89 kg/m2; blood glucose 219,4 mg/dL; total cholesterol 216,73 mg/dL; triglyceride 218,13 mg/dL; HDL 46,59 mg/dL; LDL 146,27mg/dL; MDA 2943,4 pmol/mL; C-RP 7,62 mg/L; and blood pressure 153/103 mmHg. It indicates that SM women experience dyslipidemia with low antioxidant and inflammation.Key words: Metabolic syndrome women, lipid profile, peroxide lipid, malondialdehid, C-reactive protein

Effectiveness of generic rosuvastatin in patients with ischaemic cerebrovascular disease

2012 ◽  
Vol 153 (22) ◽  
pp. 857-860 ◽  
Author(s):  
László Szapáry ◽  
Gergely Fehér
Keyword(s):  
High Density Lipoprotein ◽  
Cerebrovascular Disease ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Low Density ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Lipid Lowering Agent

Statin therapy is the cornerstone of anti-atherosclerotic treatment, and it considered obligatory in the secondary prevention of atherosclerotic diseases. Rosuvastatin is well-known and efficacious lipid-lowering agent. Generic drugs are more frequently used instead of its ancestors. Generic rosuvastatin forms have been aproved recently to the Central European market, but their safety and efficacy have not been previously examined in cerebrovascular patient populations. Patients and methods: 109 patients with documented ischaemic cerebrovascular events were included in our study. 20 mg generic rosuvastatin significantly decreased total cholesterol (5.47 vs. 3.88 mmol/l, p<0.01), low-density lipoprotein (3.16 vs. 1.84 mmol/l, p<0.01) and trigliceride levels (1.77 vs. 1.33 mmol/l, p<0.05, and there was a non-significant high-density lipoprotein increasing tendency (1.27 vs. 1.36 mmol/l, p = 0.08). There was also a significant decrease in high-sensitive C-reactive protein levels (3.73 vs. 2.82 mg/l, p<0.05). Overall, 30% decrease in total cholesterol, 42% decrease in low-density lipoprotein, 25% decrease in trigliceride and high-sensitive C-reactive protein and 9% increase in high-density lipoprotein levels were observed. Conclusions: The generic rosuvastatin studied by the authors proved to be safe and efficacious lipid-lowering agent. Based on these short term results, in daily practice, generic rosuvastatin treatment seems to be cost-effective for the treatment of patients with ischemis cerebrovascular disease. Orv. Hetil., 2012, 153, 857–860.

scholarly journals RELATİONSHİP BETWEEN ANDROGENETİC ALOPECİA AND CARDİOVASCULAR COMORBİDİTY MARKERS İN WOMEN

2020 ◽  
Vol 05 (03) ◽  
pp. 19-23
Author(s):  
Melis Gönülal ◽  
Aylin Öztürk ◽  
Fatma Yıldız
Keyword(s):  
High Density Lipoprotein ◽  
Heart Diseases ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
High Density ◽  
Androgenetic Alopecia ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Media Thickness

Background Although androgenetic alopecia is a cosmetic problem for lots of men and women, it’s also investigated about relations with systemic diseases. Severity of androgenetic alopecia was found related to coronary artery diseases in some groups. Methods Twenty seven female volunteers with androgenetic alopecia older 18 years old were enrolled to the study. Androgenetic alopecia were scored by Ludwig classification. Blood biochemical markers which are related to cardiac diseases were studied. These were serum total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, dehydroepiandrosterone sulphate,total testosterone, C reactive protein levels. As imaging carotid ultrasonography was used. Right and left common carotid arteries’ intima media thickness were measured. Results No corelation with other serum low-density lipoprotein, total chlolesterol , triglyserides , C reactive protein and androgenetic alopecia severity could be found. A negative corelation between serum high-density lipoprotein level and Ludwig severity was investigated. Conclusions Patients of androgenetic alopecia must be also concerned about cardiac diseases. Measurement of carotid arteries’ intima media thickness in people with androgenetic alopecia measurement can be helpful in determining risk of premature cardiovascular heart diseases. There is a need for more clinical studies of relationship between serum lipids especially high-density lipoprotein and androgenetic alopecia severity in women. Keywords: female type androgenetic alopecia, DHEA-S, carotid intima media thickness, cardiovascular heart diseases,HDL

scholarly journals Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3

2000 ◽  
Vol 41 (9) ◽  
pp. 1495-1508 ◽  
Author(s):  
Mohamad Navab ◽  
Susan Y. Hama ◽  
G.M. Anantharamaiah ◽  
Kholood Hassan ◽  
Greg P. Hough ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein
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