The Joint Model of Longitudinal and Survival Data—Based on Machine Learning Methods

2015 ◽  
Vol 04 (04) ◽  
pp. 252-261
Author(s):  
征 温
2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Stefan Leger ◽  
Alex Zwanenburg ◽  
Karoline Pilz ◽  
Fabian Lohaus ◽  
Annett Linge ◽  
...  

2021 ◽  
Author(s):  
Mu Yue

In high-dimensional data, penalized regression is often used for variable selection and parameter estimation. However, these methods typically require time-consuming cross-validation methods to select tuning parameters and retain more false positives under high dimensionality. This chapter discusses sparse boosting based machine learning methods in the following high-dimensional problems. First, a sparse boosting method to select important biomarkers is studied for the right censored survival data with high-dimensional biomarkers. Then, a two-step sparse boosting method to carry out the variable selection and the model-based prediction is studied for the high-dimensional longitudinal observations measured repeatedly over time. Finally, a multi-step sparse boosting method to identify patient subgroups that exhibit different treatment effects is studied for the high-dimensional dense longitudinal observations. This chapter intends to solve the problem of how to improve the accuracy and calculation speed of variable selection and parameter estimation in high-dimensional data. It aims to expand the application scope of sparse boosting and develop new methods of high-dimensional survival analysis, longitudinal data analysis, and subgroup analysis, which has great application prospects.


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