scholarly journals Development and Clinical Application of a Chemiluminescence Immunoassay for Determination of Carbohydrate Antigen 125

2016 ◽  
Vol 04 (02) ◽  
pp. 9-14
Author(s):  
志文 戴
Keyword(s):  
Clinical Application ◽  
Carbohydrate Antigen ◽  
Chemiluminescence Immunoassay ◽  
Carbohydrate Antigen 125

scholarly journals Benign Ovarian Cysts with Raised CA-125 Levels: Do We Need to Evaluate the Fallopian Tubes?

2020 ◽  
Vol 12 (04) ◽  
pp. 276-280
Author(s):  
Devesh Sharma ◽  
Anjali Vinocha
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Cyst ◽  
Transvaginal Ultrasound ◽  
Premenopausal Women ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Ovarian Cysts ◽  
Fallopian Tubes ◽  
Case Record ◽  
Carbohydrate Antigen 125

Abstract Objectives It is not clearly known whether some benign (simple) ovarian cysts can convert into cancerous cysts. Size of cyst and wall abnormalities do predict the potentiality of malignancy. Not many studies have been done to explore the malignant potential of large-sized (> 5 cm) unilocular ovarian cysts without wall abnormalities. This study evaluated the correlation between ultrasonographic size of benign ovarian cysts and carbohydrate antigen 125 (CA-125) levels. Methodology Sixty (60) premenopausal women were recruited for the study preoperatively, based on transvaginal ultrasound (TVUS) findings present in the case record sheet received along with the CA-125 sample in the biochemistry laboratories. Those cases with elevated CA-125 levels were selected, where patients had unilocular ovarian cysts without wall abnormalities. CA-125 was done using ECLIA methodology (Cobas e411, Germany). Statistical correlation was calculated between the ovarian cyst size and CA-125 levels using Spearman’s Rho coefficient. Results Mean age group of subjects were 29.7 ± 7.3 years and mean value of CA-125 (normal < 35 IU/mL) was found to be increased: 118.0 ± 147.1 IU/mL so was the mean diameter of cysts (cut off ≤ 5 cm): 48.6 ± 59.8 cm. No correlation was found between CA-125 levels and volume of ovarian cyst (r = 0.005, p = 0.680) for all subjects. Conclusions The lack of correlation between size of ovarian cysts and CA-125 levels provides a hint that the ovarian cyst epithelium does not directly express CA-125 and it may come from sites like the fallopian tube. Thus, raised level of CA-125 in benign ovarian cyst should be followed-up more closely, demanding assessment of fallopian tubes for early diagnosis of ovarian cancer. Also, algorithms can be explored to include size of ovarian cyst and CA 125 levels to predict ovarian cancer.

HPLC–APCI–MS for the determination of vitamin K1 in human plasma: Method and clinical application

2008 ◽  
Vol 875 (2) ◽  
pp. 541-545 ◽  
Author(s):  
Q SONG ◽  
A WEN ◽  
L DING ◽  
L DAI ◽  
L YANG ◽  
...  
Keyword(s):  
Human Plasma ◽  
Clinical Application ◽  
Vitamin K1 ◽  
Plasma Method

Clinical evaluation of salivary carbohydrate antigen 125 and leptin in controls and parotid tumours

Oral Diseases ◽  
2016 ◽  
Vol 22 (7) ◽  
pp. 630-638 ◽  
Author(s):  
K-Y Zhang ◽  
C-Y Liu ◽  
L Hua ◽  
S-L Wang ◽  
J Li
Keyword(s):  
Clinical Evaluation ◽  
Carbohydrate Antigen ◽  
Carbohydrate Antigen 125 ◽  
Parotid Tumours

Letters to the Editor

PEDIATRICS ◽  
1981 ◽  
Vol 68 (4) ◽  
pp. 601-602
Author(s):  
M. Spino ◽  
J. J. Thiessen ◽  
A. Isles ◽  
H. Levison ◽  
S. M. MacLeod
Keyword(s):  
Clinical Application ◽  
Drug Concentration ◽  
Apparent Volume ◽  
Volume Of Distribution ◽  
Intravenous Dose ◽  
Single Intravenous Dose ◽  
Letters To The Editor ◽  
Potential Clinical Application ◽  
Apparent Volume Of Distribution

We found the report by Feldman et al1 interesting with potential clinical application. However, we would like to point out an error in their determination of the apparent volume of distribution (V) and comment on both their methodology and results. They state that V was calculated by dividing the dose of the drug by the extrapolated y intercept for drug concentration at time 0. This method is correct for a drug which exhibits monoexponential elimination following a single intravenous dose.

Rheumatoid factor interference in the determination of carbohydrate antigen 19-9 (CA 19-9)

2006 ◽  
Vol 44 (9) ◽  
Author(s):  
Mario Berth ◽  
Eugene Bosmans ◽  
Jacques Everaert ◽  
Jan Dierick ◽  
Johan Schiettecatte ◽  
...  
Keyword(s):  
Rheumatoid Factor ◽  
Carbohydrate Antigen

AbstractClin Chem Lab Med 2006;44:1137–9.

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