scholarly journals The Exploration of Clinic-Pathological Characteristics and Treatment in Elder Women with Breast Cancer

2013 ◽  
Vol 01 (02) ◽  
pp. 9-13
Author(s):  
立华 秦
Keyword(s):  
Breast Cancer ◽  
Pathological Characteristics ◽  
Elder Women

scholarly journals Polyphenol-Enriched Blueberry Preparation Controls Breast Cancer Stem Cells by Targeting FOXO1 and miR-145

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4330
Author(s):  
Jean-François Mallet ◽  
Roghayeh Shahbazi ◽  
Nawal Alsadi ◽  
Chantal Matar
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Mirna Expression ◽  
Epigenetic Mechanism ◽  
Breast Cancer Cell Lines ◽  
Relative Expression ◽  
Target Proteins ◽  
Pathological Characteristics

Scientific evidence supports the early deregulation of epigenetic profiles during breast carcinogenesis. Research shows that cellular transformation, carcinogenesis, and stemness maintenance are regulated by epigenetic-specific changes that involve microRNAs (miRNAs). Dietary bioactive compounds such as blueberry polyphenols may modulate susceptibility to breast cancer by the modulation of CSC survival and self-renewal pathways through the epigenetic mechanism, including the regulation of miRNA expression. Therefore, the current study aimed to assay the effect of polyphenol enriched blueberry preparation (PEBP) or non-fermented blueberry juice (NBJ) on the modulation of miRNA signature and the target proteins associated with different clinical-pathological characteristics of breast cancer such as stemness, invasion, and chemoresistance using breast cancer cell lines. To this end, 4T1 and MB-MDM-231 cell lines were exposed to NBJ or PEBP for 24 h. miRNA profiling was performed in breast cancer cell cultures, and RT-qPCR was undertaken to assay the expression of target miRNA. The expression of target proteins was examined by Western blotting. Profiling of miRNA revealed that several miRNAs associated with different clinical-pathological characteristics were differentially expressed in cells treated with PEBP. The validation study showed significant downregulation of oncogenic miR-210 expression in both 4T1 and MDA-MB-231 cells exposed to PEBP. In addition, expression of tumor suppressor miR-145 was significantly increased in both cell lines treated with PEBP. Western blot analysis showed a significant increase in the relative expression of FOXO1 in 4T1 and MDA-MB-231 cells exposed to PEBP and in MDA-MB-231 cells exposed to NBJ. Furthermore, a significant decrease was observed in the relative expression of N-RAS in 4T1 and MDA-MB-231 cells exposed to PEBP and in MDA-MB-231 cells exposed to NBJ. Our data indicate a potential chemoprevention role of PEBP through the modulation of miRNA expression, particularly miR-210 and miR-145, and protection against breast cancer development and progression. Thus, PEBP may represent a source for novel chemopreventative agents against breast cancer.

scholarly journals Efficacy of angiotensin-receptor blockers on demographic and clinico-pathological characteristics of breast cancer

The Breast ◽  
2012 ◽  
Vol 21 (3) ◽  
pp. 419-420 ◽  
Author(s):  
Mehmet A.N. Şendur ◽  
Sercan Aksoy ◽  
Sebnem Yaman ◽  
Nuriye Y. Ozdemir ◽  
Nurullah Zengin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Angiotensin Receptor Blockers ◽  
Angiotensin Receptor ◽  
Pathological Characteristics ◽  
Receptor Blockers

Interval breast carcinoma: A comparison of clinical-pathological characteristics between symptomatic and screen-detected breast cancer

2014 ◽  
Vol 40 (5) ◽  
pp. 646-647
Author(s):  
B. Meshkat ◽  
R.S. Prichard ◽  
Z. Al-Hili ◽  
G.B. Bass ◽  
C. Quinn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Pathological Characteristics

scholarly journals Clinical and pathological characteristics of breast cancer patients with history of tonsillectomy

The Breast ◽  
2010 ◽  
Vol 19 (2) ◽  
pp. 152 ◽  
Author(s):  
Metin Isik ◽  
Sercan Aksoy ◽  
Didem S. Dede ◽  
Omer Dizdar ◽  
Atilla Kara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Pathological Characteristics ◽  
History Of

Clinical and Pathological Characteristics of Breast Cancer Patients with History of Appendectomy

2011 ◽  
Vol 77 (3) ◽  
pp. 382-383
Author(s):  
Metin Isik ◽  
Bilgin Sait ◽  
Sercan Aksoy ◽  
Kadri Altundag
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Pathological Characteristics ◽  
History Of
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