scholarly journals The Expression and Clinical Significance of nm23-H1 and E-Cadherin in Esophageal Squamous Cell Carcinomas

2016 ◽  
Vol 06 (04) ◽  
pp. 151-155
Author(s):  
谦和 廖
Keyword(s):  
Clinical Significance ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Esophageal Squamous Cell Carcinomas ◽  
E Cadherin

scholarly journals Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas

2007 ◽  
Vol 21 (3) ◽  
pp. 271-281 ◽  
Author(s):  
Sima Salahshor ◽  
Richard Naidoo ◽  
Stefano Serra ◽  
Warren Shih ◽  
Ming-Sound Tsao ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Wnt Signaling Pathway ◽  
Squamous Cell Carcinomas ◽  
Esophageal Squamous Cell Carcinomas ◽  
E Cadherin

scholarly journals Transgelin Inhibits the Malignant Progression of Esophageal Squamous Cell Carcinomas by Regulating Epithelial–Mesenchymal Transition

2021 ◽  
Vol 11 ◽  
Author(s):  
Boli Yang ◽  
Qiuyu Chen ◽  
Changshan Wan ◽  
Siyuan Sun ◽  
Lanping Zhu ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Squamous Cell Carcinomas ◽  
Malignant Progression ◽  
Expression Level ◽  
Migration And Invasion ◽  
Control Group ◽  
Mesenchymal Transition ◽  
Esophageal Squamous Cell Carcinomas ◽  
E Cadherin

ObjectiveThis article investigates the role of Transgelin (TAGLN) in the epithelial–mesenchymal transition (EMT) of esophageal squamous cell carcinomas (ESCC) and its possible mechanism of inhibiting the invasion of these cancers.MethodsTissue specimens and clinical information of patients with ESCC were collected to analyze the relationship between Transgelin expression level and prognosis of patients with ESCC. Transgelin siRNA was used to knock down Transgelin expression. The expression of Transgelin in Eca-109 and KYSE-150 cells was overexpressed by Transgelin-overexpressing plasmid. The effects of Transgelin overexpression and knockdown on the proliferation of Eca-109 and KYSE-150 cells were examined by Transwell chamber, scratch assay, and CCK-8 cell activity assay. RT-PCR and Western blot were used to detect the effect of Transgelin overexpression or knockdown on the mRNA and protein expressions of E-cadherin and Vimentin. TCGA data were used to analyze Transgelin co-expressed genes and further study the GO and KEGG enrichment analysis results under the influence of Transgelin.ResultsThe expression of Transgelin was low in ESCC, and its expression level was positively correlated with the prognosis of patients with ESCC. The targeted Transgelin siRNA and Transgelin-overexpressing plasmid can effectively regulate the expression of Transgelin mRNA and protein in Eca-109 and KYSE-150 cells. After overexpression of Transgelin, the invasion and proliferation abilities of Eca-109 and KYSE-150 cells were significantly decreased compared with those of the control group (P < 0.05). However, Transgelin knockdown could promote the proliferation, migration, and invasion of ESCC cells. The overexpression of Transgelin inhibits EMT in ESCC. With the increase of Transgelin expression in Eca-109 and KYSE-150 cells, the expression of E-cadherin increased, while the expression of Vimentin decreased, and the difference was statistically significant (P < 0.05).ConclusionTransgelin can inhibit the malignant progression of ESCC by inhibiting the occurrence of EMT.

Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas

PROTEOMICS ◽  
2015 ◽  
Vol 15 (17) ◽  
pp. 3087-3100 ◽  
Author(s):  
Lihong Hao ◽  
Xin Zhou ◽  
Shuqing Liu ◽  
Mingzhong Sun ◽  
Yang Song ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Gapdh Expression ◽  
Esophageal Squamous Cell Carcinomas ◽  
Proliferation And Invasion

Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH

2002 ◽  
Vol 296 (1) ◽  
pp. 152-155 ◽  
Author(s):  
Tomoki Ishizuka ◽  
Chikako Tanabe ◽  
Hiromi Sakamoto ◽  
Kazuhiko Aoyagi ◽  
Masahiko Maekawa ◽  
...  
Keyword(s):  
Gene Amplification ◽  
Squamous Cell ◽  
Array Cgh ◽  
Squamous Cell Carcinomas ◽  
Dna Array ◽  
Esophageal Squamous Cell Carcinomas

scholarly journals Expression of YY1 correlates with progression and metastasis in esophageal squamous cell carcinomas

2014 ◽  
pp. 1753 ◽  
Author(s):  
Judong Luo ◽  
LiLi Cao ◽  
Xin Jiang ◽  
Kejun Dai ◽  
Shuyu Zhang ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Esophageal Squamous Cell Carcinomas
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