scholarly journals HISTOCHEMICAL DEMONSTRATION OF INCREASED ACTIVITY OF γ-GLUTAMYL TRANSPEPTIDASE IN RAT LIVER DURING HEPATOCARCINOGENESIS

1976 ◽  
Vol 9 (2) ◽  
pp. 168-179 ◽  
Author(s):  
MASAOKI HARADA ◽  
KAZUHIKO OKABE ◽  
KAZUTOSHI SHIBATA ◽  
HIROTAKE MASUDA ◽  
KEIKO MIYATA ◽  
...  
Keyword(s):  
Rat Liver ◽  
Histochemical Demonstration ◽  
Glutamyl Transpeptidase ◽  
Increased Activity

scholarly journals Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide

1971 ◽  
Vol 124 (4) ◽  
pp. 767-777 ◽  
Author(s):  
F. De Matteis
Keyword(s):  
Rat Liver ◽  
Microsomal Fraction ◽  
Direct Evidence ◽  
Gradual Increase ◽  
Rapid Loss ◽  
Metabolizing Enzymes ◽  
Liver Microsomal Fraction ◽  
Green Pigments ◽  
Cytochrome P 450 ◽  
Increased Activity

1. The effect of a single dose of 2-allyl-2-isopropylacetamide on the cytochrome P-450 concentration in rat liver microsomal fraction was studied. The drug caused a rapid loss of cytochrome P-450 followed by a gradual increase to above the normal concentration. 2. The loss of cytochrome P-450 was accompanied by a loss of microsomal haem and by a brown–green discoloration of the microsomal fraction suggesting that a change in the chemical constitution of the lost haem had taken place. Direct evidence for this was obtained by prelabelling the liver haems with radioactive 5-aminolaevulate: the drug caused a loss of radioactivity from the haem with an increase of radioactivity in a fraction containing certain un-identified green pigments. 3. Evidence was obtained by a dual-isotopic procedure that rapidly turning-over haem(s) may be preferentially affected. 4. The loss of cytochrome P-450 as well as the loss of microsomal haem and the discoloration of the microsomal fraction were more intense in animals pretreated with phenobarbitone and were much less evident when compound SKF 525-A (2-diethylaminoethyl 3,3-diphenylpropylacetate) was given before 2-allyl-2-isopropylacetamide, suggesting that the activity of the drug-metabolizing enzymes may be involved in these effects. 5. The relevance of the destruction of liver haem to the increased activity of 5-aminolaevulate synthetase caused by 2-allyl-2-isopropylacetamide is discussed.

scholarly journals ETOH depresses rat liver γ-glutamyl transpeptidase

1978 ◽  
Vol 74 (5) ◽  
pp. 1095 ◽  
Author(s):  
J.S. Singer ◽  
M.M. Kaplan
Keyword(s):  
Rat Liver ◽  
Glutamyl Transpeptidase

scholarly journals Tissue- and developmental-stage-specific methylation in the two kidney promoters of the rat γ-glutamyl transpeptidase gene

1992 ◽  
Vol 287 (3) ◽  
pp. 691-694 ◽  
Author(s):  
J H Baik ◽  
S Siegrist ◽  
G Giuili ◽  
O Lahuna ◽  
F Bulle ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Developmental Stage ◽  
Rat Liver ◽  
Kidney Development ◽  
Rat Kidney ◽  
Liver Development ◽  
Gamma Glutamyl Transpeptidase ◽  
Site Specific ◽  
Adult Rat ◽  
Glutamyl Transpeptidase

We have investigated, using DNA methylation patterning, the site-specific methylation of promoters I and II of the rat gamma-glutamyl transpeptidase gene. This analysis was done in fetal, newborn and adult rat kidney, in which promoters I and II are progressively active during development, as well as in rat liver, which never expresses mRNAs from these two promoters. During kidney development, a progressive demethylation occurs in the promoter I and II region, specially at the level of the most proximal MspI site of promoter II. A progressive reorganization of the methylated sites within the 5′ end of the gene also occurs during liver development.

Characterization of a promoter for γ-glutamyl transpeptidase activated in rat liver in response to aflatoxin B1 and ethoxyquin1

1995 ◽  
Vol 14 (4) ◽  
pp. 251-262 ◽  
Author(s):  
Susan A. Griffiths ◽  
Valerie M. Good ◽  
Linda A. Gordon ◽  
E. Ann Hudson ◽  
Mandy C. Barrett ◽  
...  
Keyword(s):  
Rat Liver ◽  
Aflatoxin B1 ◽  
Glutamyl Transpeptidase

Induction of γ-glutamyl transpeptidase mRNA by aflatoxin B1 and ethoxyquin in rat liver

1987 ◽  
Vol 8 (5) ◽  
pp. 737-740 ◽  
Author(s):  
Christine A. Power ◽  
Susan A. Griffiths ◽  
Janet L. Simpson ◽  
Yannick Laperche ◽  
Georges Guellaen ◽  
...  
Keyword(s):  
Rat Liver ◽  
Aflatoxin B1 ◽  
Glutamyl Transpeptidase
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