scholarly journals Changes in Nitric Oxide Synthase-Containing Neurons in the Brain of Thiamine-Deficient Mice.

2000 ◽  
Vol 33 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Hiroko Matsushita ◽  
Yoshihiro Takeuchi ◽  
Kitaro Kosaka ◽  
Shinji Fushiki ◽  
Mitsuhiro Kawata ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
The Brain ◽  
Deficient Mice

P4-061: INCREASED UREA LEVELS IN THE BRAIN OF ENDOTHELIAL NITRIC OXIDE SYNTHASE DEFICIENT MICE

2006 ◽  
Vol 14 (7S_Part_27) ◽  
pp. P1456-P1456
Author(s):  
Ashwini Hariharan ◽  
Yu Jing ◽  
Nicola D. Collie ◽  
Hu Zhang ◽  
Ping Liu
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
The Brain ◽  
Deficient Mice

Localization of the cGMP-dependent protein kinases in relation to nitric oxide synthase in the brain

1999 ◽  
Vol 17 (1) ◽  
pp. 45-55 ◽  
Author(s):  
A.E.-D El-Husseini ◽  
J Williams ◽  
P.B Reiner ◽  
S Pelech ◽  
S.R Vincent
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Protein Kinases ◽  
Dependent Protein ◽  
Oxide Synthase ◽  
The Brain

Resistance of neuronal nitric oxide synthase-deficient mice to cocaine-induced locomotor sensitization

1998 ◽  
Vol 140 (3) ◽  
pp. 378-386 ◽  
Author(s):  
Y. Itzhak ◽  
Syed F. Ali ◽  
Julio L. Martin ◽  
M. Dean Black ◽  
Paul L. Huang
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Locomotor Sensitization ◽  
Oxide Synthase ◽  
Deficient Mice

Selected Contribution: Differential role of nitric oxide synthase isoforms in fever of different etiologies: studies using Nosgene-deficient mice

2003 ◽  
Vol 94 (6) ◽  
pp. 2534-2544 ◽  
Author(s):  
Wieslaw Kozak ◽  
Anna Kozak
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Corn Oil ◽  
Normal Male ◽  
Wild Type ◽  
Oxide Synthase ◽  
And Control ◽  
Nos Isoforms ◽  
Deficient Mice

Male C57BL/6J mice deficient in nitric oxide synthase (NOS) genes (knockout) and control (wild-type) mice were implanted intra-abdominally with battery-operated miniature biotelemeters (model VMFH MiniMitter, Sunriver, OR) to monitor changes in body temperature. Intravenous injection of lipopolysaccharide (LPS; 50 μg/kg) was used to trigger fever in response to systemic inflammation in mice. To induce a febrile response to localized inflammation, the mice were injected subcutaneously with pure turpentine oil (30 μl/animal) into the left hindlimb. Oral administration (gavage) of N G-monomethyl-l-arginine (l-NMMA) for 3 days (80 mg · kg−1 · day−1in corn oil) before injection of pyrogens was used to inhibit all three NOSs ( N G-monomethyl-d-arginine acetate salt and corn oil were used as control). In normal male C57BL/6J mice, l-NMMA inhibited the LPS-induced fever by ∼60%, whereas it augmented fever by ∼65% in mice injected with turpentine. Challenging the respective NOS knockout mice with LPS and with l-NMMA revealed that inducible NOS and neuronal NOS isoforms are responsible for the induction of fever to LPS, whereas endothelial NOS (eNOS) is not involved. In contrast, none of the NOS isoforms appeared to trigger fever to turpentine. Inhibition of eNOS, however, exacerbates fever in mice treated with l-NMMA and turpentine, indicating that eNOS participates in the antipyretic mechanism. These data support the hypothesis that nitric oxide is a regulator of fever. Its action differs, however, depending on the pyrogen used and the NOS isoform.

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