scholarly journals Calcium-Binding Proteins in the Central Nervous System.

1994 ◽  
Vol 27 (2) ◽  
pp. 93-106 ◽  
Author(s):  
AKIKO SETO-OHSHIMA
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins ◽  
The Central Nervous System

scholarly journals New Approach for Untangling the Role of Uncommon Calcium-Binding Proteins in the Central Nervous System

2021 ◽  
Vol 11 (5) ◽  
pp. 634
Author(s):  
Krisztina Kelemen ◽  
Tibor Szilágyi
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Expression Profiles ◽  
Calcium Binding Proteins ◽  
Brain Atlas ◽  
Specific Cell ◽  
The Central Nervous System

Although Ca2+ ion plays an essential role in cellular physiology, calcium-binding proteins (CaBPs) were long used for mainly as immunohistochemical markers of specific cell types in different regions of the central nervous system. They are a heterogeneous and wide-ranging group of proteins. Their function was studied intensively in the last two decades and a tremendous amount of information was gathered about them. Girard et al. compiled a comprehensive list of the gene-expression profiles of the entire EF-hand gene superfamily in the murine brain. We selected from this database those CaBPs which are related to information processing and/or neuronal signalling, have a Ca2+-buffer activity, Ca2+-sensor activity, modulator of Ca2+-channel activity, or a yet unknown function. In this way we created a gene function-based selection of the CaBPs. We cross-referenced these findings with publicly available, high-quality RNA-sequencing and in situ hybridization databases (Human Protein Atlas (HPA), Brain RNA-seq database and Allen Brain Atlas integrated into the HPA) and created gene expression heat maps of the regional and cell type-specific expression levels of the selected CaBPs. This represents a useful tool to predict and investigate different expression patterns and functions of the less-known CaBPs of the central nervous system.

scholarly journals Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease

2019 ◽  
Vol 20 (9) ◽  
pp. 2146 ◽  
Author(s):  
Richard Fairless ◽  
Sarah K. Williams ◽  
Ricarda Diem
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Intracellular Calcium ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins ◽  
First Line ◽  
Ef Hand ◽  
Key Factor

Neuronal subpopulations display differential vulnerabilities to disease, but the factors that determine their susceptibility are poorly understood. Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis. Since neurons expressing different calcium-binding proteins have been reported to be differentially susceptible to degeneration, it can be hypothesized that rather than just serving as markers of different neuronal subpopulations, they might actually be a key determinant of survival. In this review, we will summarize some of the evidence that expression of the EF-hand calcium-binding proteins, calbindin, calretinin and parvalbumin, may influence the susceptibility of distinct neuronal subpopulations to disease processes.

Differential expression of the EF-hand calcium-binding protein calsensin in the central nervous system of hirudinid leeches

1996 ◽  
Vol 286 (3) ◽  
pp. 357-364 ◽  
Author(s):  
Mark Veldman ◽  
Yueqiao Huang ◽  
John Jellies ◽  
Kristen M. Johansen ◽  
Jørgen Johansen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Differential Expression ◽  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Ef Hand ◽  
The Central Nervous System

Lethal phenotype of mice carrying a Sept11 null mutation

2011 ◽  
Vol 392 (8-9) ◽  
pp. 779-781 ◽  
Author(s):  
Sabrina Röseler ◽  
Kirstin Sandrock ◽  
Ingrid Bartsch ◽  
Anja Busse ◽  
Heymut Omran ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Binding Proteins ◽  
Vesicle Trafficking ◽  
In Utero ◽  
High Expression ◽  
Synaptic Connectivity ◽  
Null Mutation ◽  
Gtp Binding ◽  
The Central Nervous System

Abstract Septins are cytoskeletal GTP-binding proteins involved in processes characterized by active membrane movement, such as cytokinesis, vesicle trafficking and exocytosis. Most septins are expressed ubiquitously, however, some septins accumulate in particular tissues. The ubiquitous SEPT11 also shows high expression levels in the central nervous system and in platelets. Here, SEPT11 is involved in vesicle trafficking and may play a role in synaptic connectivity. Interestingly, mice that harbor a homozygous Sept11 null mutation, die in utero. From day 11.5 post coitum onwards, development of homozygous embryos seems to be retarded and the embryos from day 13.5 onwards were dead.

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