scholarly journals In vivo Bromodeoxyuridine Incorporation in Normal Rat Liver: Immunohistochemical Detection of Streaming Cells and Measurement of Labelling Indices.

1994 ◽  
Vol 27 (1) ◽  
pp. 45-49 ◽  
Author(s):  
NADIR ARBER ◽  
GERSHOM ZAJICEK ◽  
JOHANATAN M. SCHAPIRO ◽  
JACOB RATTAN ◽  
JARDENA NORDENBERG ◽  
...  
Keyword(s):  
Rat Liver ◽  
Immunohistochemical Detection ◽  
Normal Rat

scholarly journals Irreversible inhibition of putrescine-stimulated S-adenosyl-l-methionine decarboxylase by berenil and pentamidine

1985 ◽  
Vol 231 (1) ◽  
pp. 165-169 ◽  
Author(s):  
E Karvonen ◽  
L Kauppinen ◽  
T Partanen ◽  
H Pösö
Keyword(s):  
Rat Liver ◽  
Single Injection ◽  
Adenosylmethionine Decarboxylase ◽  
Irreversible Inhibition ◽  
Drug Concentrations ◽  
Bacterial Enzyme ◽  
Azo Group ◽  
Benzene Rings ◽  
Normal Rat

The putrescine-stimulated S-adenosyl-L-methionine decarboxylases from rat liver and yeast were strongly inhibited by Berenil and to a lesser extent by Pentamidine. Ten times greater drug concentrations were needed to achieve a similar level of inhibition of a Mg2+-stimulated bacterial enzyme. The inhibition was irreversible in that extensive dialyses or precipitation with (NH4)2SO4 did not restore enzyme activity. Putrescine did not protect the enzyme against Berenil, but adenosylmethionine either alone or with putrescine partially protected the irreversible action of Berenil. The compound 4,4′-diamidinodiphenylamine, which differs from Berenil only in lacking the azo group between benzene rings, was a weaker inhibitor than Berenil, and its inhibition was reversible. Berenil also inhibited the activity of adenosylmethionine decarboxylase in vivo, by depressing the activity of the enzyme in normal rat liver, for at least 24 h after a single injection (50 mg/kg body wt.) of the drug.

Effect of Liver on Lipolysis by Normal and Postheparin Sera in the Rat

1956 ◽  
Vol 185 (1) ◽  
pp. 18-22 ◽  
Author(s):  
Judy A. Spitzer ◽  
John J. Spitzer
Keyword(s):  
Rat Liver ◽  
Lipolytic Activity ◽  
Factor Activity ◽  
Rat Serum ◽  
Oil Emulsion ◽  
Isolated Rat Liver ◽  
Normal Rat ◽  
Isolated Liver ◽  
Isolated Rat

Lipolysis by sera heparinized in vivo and by normal sera was studied after perfusion through isolated rat liver. The rate of clearing of an oil emulsion by serum containing clearing factor was decreased after perfusion through the liver. The extent of clearing was not always affected. Clearing factor activity was lessened by incubation with heparinase (prepared from rabbit livers). Normal rat serum exhibited consistent lipolytic activity following perfusion through the isolated liver. This activity was not due to clearing factor.

In vivo proton NMR studies of normal rat liver

1989 ◽  
Vol 83 (3) ◽  
pp. 595-600
Author(s):  
J.D Hazle ◽  
P.A Narayana ◽  
W.A Kudrle
Keyword(s):  
Rat Liver ◽  
Proton Nmr ◽  
Nmr Studies ◽  
Normal Rat

Autocrine expression of activated transforming growth factor-β1 induces apoptosis in normal rat liver

2001 ◽  
Vol 280 (1) ◽  
pp. G139-G148 ◽  
Author(s):  
Laura W. Schrum ◽  
Mark A. Bird ◽  
Olga Salcher ◽  
Elmar-Reinhold Burchardt ◽  
Joe W. Grisham ◽  
...  
Keyword(s):  
Growth Factor ◽  
Rat Liver ◽  
Transforming Growth Factor ◽  
Growth Control ◽  
Rat Hepatocytes ◽  
Transforming Growth Factor Β1 ◽  
Hepatocyte Apoptosis ◽  
Normal Rat ◽  
Induced Apoptosis

The aim of this study was to determine the differential effects of latent and activated transforming growth factor (TGF)-β1in growth control of normal and proliferating hepatocytes in vivo. Rats were injected with adenoviruses expressing control transgenes (Ctrl), latent TGF-β1 [TGF-β(L)], or activated TGF-β1 [TGF-β(A)]. Additional animals underwent two-thirds partial hepatectomy (PH) 24 h after injection. Increased hepatocyte apoptosis was observed in TGF-β(A)-injected but not TGF-β(L)-injected animals 24 h postinjection (10.5%) compared with Ctrl animals (0.37%). The percent of apoptotic cells increased to 32.1% in TGF-β(A)-injected animals 48 h after injection. Furthermore, TGF-β(A)-injected rats did not survive 24 h after PH. Four hours after PH, 0.25 and 14.1% apoptotic hepatocytes were seen in Ctrl- and TGF-β(A)-injected rats, respectively. TGF-β(A)-induced apoptosis in primary rat hepatocytes was blocked with a pancaspase inhibitor. Thus autocrine expression of TGF-β(A) but not TGF-β(L) induces hepatocyte apoptosis in the normal rat liver. Rats overexpressing TGF-β(A) do not survive two-thirds PH due to hepatic apoptosis. Thus activation of TGF-β1 may be a critical step in the growth control of normal and proliferating rat hepatocytes.

Effect of orotic acid on in vivo DNA synthesis in hepatocytes of normal rat liver and in hepatic foci/nodules

1993 ◽  
Vol 14 (5) ◽  
pp. 907-912 ◽  
Author(s):  
A. Sheikh ◽  
A. Yusuf ◽  
E. Laconi ◽  
P.M. Rao ◽  
S. Rajalakshmi ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Rat Liver ◽  
Orotic Acid ◽  
Normal Rat

Work in progress: ultrasonic texture of normal rat liver tissue using a standardized in vivo measurement.

Radiology ◽  
1982 ◽  
Vol 145 (3) ◽  
pp. 773-775 ◽  
Author(s):  
G Horev ◽  
R R Price ◽  
J J Erickson ◽  
A C Fleischer ◽  
A E James
Keyword(s):  
Rat Liver ◽  
Liver Tissue ◽  
Work In Progress ◽  
In Vivo Measurement ◽  
Normal Rat

Dependence of photodynamic threshold dose on treatment parameters in normal rat liver in vivo

1991 ◽  
Author(s):  
Thomas J. Farrell ◽  
Brian C. Wilson ◽  
Michael S. Patterson ◽  
Rowena Chow
Keyword(s):  
Rat Liver ◽  
Threshold Dose ◽  
Normal Rat
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