scholarly journals Immunohistochemical Evaluation of the Effect of TZP-4238. Possible Androgen Receptor Antagonist in Rat Prostate.

1993 ◽  
Vol 26 (6) ◽  
pp. 537-541 ◽  
Author(s):  
MASANORI MURAKOSHI ◽  
RIE INADA ◽  
MASASHI TAGAWA ◽  
ATSUSHI MIZOKAMI ◽  
MINORU SUZUKI
Keyword(s):  
Androgen Receptor ◽  
Receptor Antagonist ◽  
Androgen Receptor Antagonist ◽  
Rat Prostate

scholarly journals Influence of Androgen Receptor Antagonist MDV3100 Therapy on Rats With Benign Prostatic Hyperplasia

2021 ◽  
Vol 25 (3) ◽  
pp. 219-228
Author(s):  
Minggen Yang ◽  
Zhenqiang Xu ◽  
Zhiming Zhuang
Keyword(s):  
Androgen Receptor ◽  
Benign Prostatic Hyperplasia ◽  
Inflammatory Response ◽  
Receptor Antagonist ◽  
Signaling Pathway ◽  
Inflammatory Cytokines ◽  
Testosterone Propionate ◽  
Prostatic Hyperplasia ◽  
Androgen Receptor Antagonist ◽  
Rat Prostate

Purpose: To probe the effect and mechanism of androgen receptor antagonist MDV3100 on benign prostatic hyperplasia (BPH) of ratsMethods: BPH rat model was induced by testosterone propionate. Then antagomir-miR-21-3p or agomir-miR-21-3p was injected into rats before MDV3100 treatment. The prostate index was measured by weighing the wet weight of the rat prostate. The structural morphology of rat prostate was observed after hematoxylin & eosin staining. Immunohistochemistry was applied to evaluate the expression levels of Ki-6 and inflammatory cytokines (interleukin [IL]-6, IL-18, and tumor necrosis factor-α) in rat prostate tissues. Quantitative reverse transcription polymerase chain reaction was utilized for assessment of miR-21-3p expression, and Western blot for the performance of the phosphorylation levels of IKKα and p65.Results: Injection of testosterone propionate caused increased prostate gland hyperplasia, heightened miR-21-3p level, and activated nuclear factor-kappa B (NF-κB) signaling pathway. Additionally, BPH was accompanied by inflammatory response, as evidenced by enhanced expressions of Ki-67 and inflammatory cytokines. MDV3100 exposure ameliorated BPH and suppressed miR-21-3p expression. Overexpression of miR-21-3p intensified BPH and inflammation level, while knockdown of miR-21-3p relieved BPH. The coeffect of miR-21-3p upregulation and MDV3100 subjection led to higher inflammatory response, elevated phosphorylation levels of IKKα and p65 than MDV3100 treatment alone.Conclusions: Androgen receptor antagonist MDV3100 alleviates BPH and inflammatory response through miR-21-3p downregulation and NF-κB signaling pathway blockade.

Computational and Functional Analysis of the Androgen Receptor Antagonist Atraric Acid and Its Derivatives

2013 ◽  
Vol 13 (5) ◽  
pp. 801-810 ◽  
Author(s):  
Maria Papaioannou ◽  
Annu A. Soderholm ◽  
Wei Hong ◽  
Yifan Dai ◽  
Julia Roediger ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Androgen Receptor ◽  
Receptor Antagonist ◽  
Androgen Receptor Antagonist

scholarly journals Enzalutamide, an Androgen Receptor Antagonist, Enhances Myeloid Cell–Mediated Immune Suppression and Tumor Progression

2020 ◽  
Vol 8 (9) ◽  
pp. 1215-1227 ◽  
Author(s):  
Camila R. Consiglio ◽  
Olga Udartseva ◽  
Kimberly D. Ramsey ◽  
Chioma Bush ◽  
Sandra O. Gollnick
Keyword(s):  
Androgen Receptor ◽  
Tumor Progression ◽  
Receptor Antagonist ◽  
Immune Suppression ◽  
Myeloid Cell ◽  
Androgen Receptor Antagonist
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