scholarly journals Heterotopic salivary gland tissue in lymph nodes of head and neck: An immunohistochemical study.

1991 ◽  
Vol 24 (6) ◽  
pp. 579-589 ◽  
Author(s):  
MASANORI SHINOHARA ◽  
TAKESHI HARADA ◽  
MASUICHIRO OKA ◽  
KAZUTO YAMADA ◽  
PRASHANTA SHRESTHA ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Immunohistochemical Study ◽  
Salivary Gland Tissue ◽  
Gland Tissue

A review of heterotopia and associated salivary gland neoplasms of the head and neck

1999 ◽  
Vol 113 (4) ◽  
pp. 299-303 ◽  
Author(s):  
Alfio Ferlito ◽  
Giulia Bertino ◽  
Alessandra Rinaldo ◽  
Giacinto M. Mannarà ◽  
Kenneth O. Devaney
Keyword(s):  
Salivary Gland ◽  
Head And Neck ◽  
Critical Review ◽  
Neck Mass ◽  
Diagnostic Assessment ◽  
Review Of The Literature ◽  
Salivary Gland Tissue ◽  
Gland Tissue ◽  
Node Involvement ◽  
Warthin’S Tumour

AbstractSalivary tissue neoplasms may involve normal, accessory and heterotopic salivary gland tissue. A case of Warthin's tumour originating from heterotopic salivary gland tissue of the upper neck is reported. The radioactive uptake of 131I, evidenced in the neck mass in its pre-diagnostic assessment, suggested a diagnosis of cervical node involvement from a primary malignant thyroid neoplasm. A critical review of the literature on heterotopic salivary gland tissue neoplasms of the head and neck is also presented.

Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients

2019 ◽  
Vol 2019 (53) ◽  
Author(s):  
Siri Beier Jensen ◽  
Arjan Vissink ◽  
Kirsten H Limesand ◽  
Mary E Reyland
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Salivary Gland ◽  
Head And Neck ◽  
Neck Cancer ◽  
Radiation Injury ◽  
Salivary Gland Tissue ◽  
Gland Tissue ◽  
Salivary Gland Hypofunction ◽  
Gland Function

AbstractBackgroundThe most manifest long-term consequences of radiation therapy in the head and neck cancer patient are salivary gland hypofunction and a sensation of oral dryness (xerostomia).MethodsThis critical review addresses the consequences of radiation injury to salivary gland tissue, the clinical management of salivary gland hypofunction and xerostomia, and current and potential strategies to prevent or reduce radiation injury to salivary gland tissue or restore the function of radiation-injured salivary gland tissue.ResultsSalivary gland hypofunction and xerostomia have severe implications for oral functioning, maintenance of oral and general health, and quality of life. Significant progress has been made to spare salivary gland function chiefly due to advances in radiation techniques. Other strategies have also been developed, e.g., radioprotectors, identification and preservation/expansion of salivary stem cells by stimulation with cholinergic muscarinic agonists, and application of new lubricating or stimulatory agents, surgical transfer of submandibular glands, and acupuncture.ConclusionMany advances to manage salivary gland hypofunction and xerostomia induced by radiation therapy still only offer partial protection since they are often of short duration, lack the protective effects of saliva, or potentially have significant adverse effects. Intensity-modulated radiation therapy (IMRT), and its next step, proton therapy, have the greatest potential as a management strategy for permanently preserving salivary gland function in head and neck cancer patients.Presently, gene transfer to supplement fluid formation and stem cell transfer to increase the regenerative potential in radiation-damaged salivary glands are promising approaches for regaining function and/or regeneration of radiation-damaged salivary gland tissue.

Heterotopic salivary gland tissue in lymph nodes of the cervical region

1992 ◽  
Vol 21 (3) ◽  
pp. 166-171 ◽  
Author(s):  
Masanori Shinohara ◽  
Takeshi Harada ◽  
Seiji Nakamura ◽  
Masuichiro Oka ◽  
Hideo Tashiro
Keyword(s):  
Salivary Gland ◽  
Lymph Nodes ◽  
Cervical Region ◽  
Salivary Gland Tissue ◽  
Gland Tissue

scholarly journals Sialolipoma of the Floor of the Mouth with Immunohistological Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Ahmed A. Zahrani ◽  
Ahmed Qannam ◽  
Ra’ed Al Sadhan ◽  
Ibrahim O. Bello
Keyword(s):  
Salivary Gland ◽  
Head And Neck ◽  
Salivary Glands ◽  
Floor Of The Mouth ◽  
Salivary Gland Tissue ◽  
Major Salivary Glands ◽  
Gland Tissue ◽  
Immunohistological Analysis

Lipomas are relatively rare in the head and neck, and sialolipoma was described as an entity about 20 years ago as lipoma that entraps salivary gland tissue. Less than 10 cases have been described in the floor of the mouth not related to the major salivary glands. Here, we report a case of sialolipoma affecting the floor of the mouth in a 47-year-old patient and reviewed the clinical, histologic, and immunohistochemical characteristics of the lesion.

Hyperglycemia Induces Generation of Reactive Oxygen Species and Accelerates Apoptotic Cell Death in Salivary Gland Cells

Pathobiology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Naoyuki Matsumoto ◽  
Daisuke Omagari ◽  
Ryoko Ushikoshi-Nakayama ◽  
Tomoe Yamazaki ◽  
Hiroko Inoue ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Salivary Gland ◽  
Tissue Injury ◽  
Ros Production ◽  
Oxygen Species ◽  
Saliva Secretion ◽  
Salivary Gland Tissue ◽  
Gland Tissue

<b><i>Introduction:</i></b> Type-2 diabetes mellitus (T2DM) is associated with several systemic vascular symptoms and xerostomia. It is considered that hyperglycemia-induced polyuria and dehydration cause decreased body-water volume, leading to decreased saliva secretion and, ultimately, xerostomia. In T2DM, increased production of reactive oxygen species (ROS) causes tissue damage to vascular endothelial cells as well as epithelial tissue, including pancreas and cornea. Hence, a similar phenomenon may occur in other tissues and glands in a hyperglycemic environment. <b><i>Methods:</i></b> Salivary gland tissue injury was examined, using T2DM model mouse (db/db). Transferase‐mediated dUTP nick‐end labeling (TUNEL) was conducted to evaluate tissue injury. The levels of malondialdehyde (MDA) and 8-hydroxy-2′-deoxyguanosine, Bax/Bcl-2 ratio were measured as indicator of oxidative stress. Moreover, in vitro ROS production and cell injury was evaluated by mouse salivary gland-derived normal cells under high-glucose condition culture. <b><i>Results:</i></b> In vivo and in vitro analysis showed a higher percentage of TUNEL-positive cells and higher levels of MDA and 8-hydroxy-2′-deoxyguanosine in salivary gland tissue of db/db mice. This suggests damage of saliva secretion-associated lipids and DNA by hyperglycemic-induced oxidative stress. To analyze the mechanism by which hyperglycemia promotes ROS production, mouse salivary gland-derived cells were isolated. The cell culture with high-glucose medium enhanced ROS production and promotes apoptotic and necrotic cell death. <b><i>Conclusion:</i></b> These findings suggest a novel mechanism whereby hyperglycemic-induced ROS production promotes salivary gland injury, resulting in hyposalivation.

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