scholarly journals Induced Expression of Cancer Stem Cell Markers ALDH1A3 and Sox-2 in Hierarchical Reconstitution of Apoptosis-resistant Human Breast Cancer Cells

2016 ◽  
Vol 49 (5) ◽  
pp. 149-158 ◽  
Author(s):  
Karin Kashii-Magaribuchi ◽  
Rie Takeuchi ◽  
Yuko Haisa ◽  
Akemi Sakamoto ◽  
Aimi Itoh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Stem Cell Markers ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cancer Stem Cell Markers

scholarly journals Cancer-Associated Fibroblasts Regulate the Plasticity of Breast Cancer Stemness through the Production of Leukemia Inhibitory Factor

Life ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1298
Author(s):  
Nazanin Vaziri ◽  
Laleh Shariati ◽  
Ali Zarrabi ◽  
Ali Farazmand ◽  
Shaghayegh Haghjooy Javanmard
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Leukemia Inhibitory Factor ◽  
Breast Cancer Cells ◽  
Stem Cell Markers ◽  
Cancer Associated Fibroblasts ◽  
Cell Markers ◽  
Cancer Stem Cell Markers

Leukemia inhibitory factor (LIF), as a member of the interleukin-6 cytokine family, plays a complex role in solid tumors. However, the effect of LIF as a tumor microenvironment factor on plasticity control in breast cancer remains largely unknown. In this study, an in vitro investigation is conducted to determine the crosstalk between breast cancer cells and fibroblasts. Based on the results, cancer-associated fibroblasts are producers of LIF in the cocultivation system with breast cancer cells. Treatment with the CAF-CM and human LIF protein significantly promoted stemness through the dedifferentiation process and regaining of stem-cell-like properties. In addition, the results indicate that activation of LIFR signaling in breast cancer cells in the existence of CAF-secreted LIF can induce Nanog and Oct4 expression and increase breast cancer stem cell markers CD24−/CD44+. In contrast, suppression of the LIF receptor by human LIF receptor inhibition antibody decreased the cancer stem cell markers. We found that LIF was frequently overexpressed by CAFs and that LIF expression is necessary for dedifferentiation of breast cancer cell phenotype and regaining of cancer stem cell properties. Our results suggest that targeting LIF/LIFR signaling might be a potent therapeutic strategy for breast cancer and the prevention of tumor recurrence.

scholarly journals Purging of human breast cancer cells from stem cell products with an adenovirus containing p53

2000 ◽  
Vol 7 (2) ◽  
pp. 197-206 ◽  
Author(s):  
Manabu Hirai ◽  
Linda S Kelsey ◽  
Mei Vaillancourt ◽  
Daniel C Maneval ◽  
Tsutomu Watanabe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast
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