scholarly journals Effects of Repeated Administration of Pilocarpine and Isoproterenol on Aquaporin-5 Expression in Rat Salivary Glands

2013 ◽  
Vol 46 (6) ◽  
pp. 187-197 ◽  
Author(s):  
Taketo Susa ◽  
Nobuhiko Sawai ◽  
Takeo Aoki ◽  
Akiko Iizuka-Kogo ◽  
Hiroshi Kogo ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Repeated Administration ◽  
Aquaporin 5 ◽  
Rat Salivary Glands

scholarly journals Occlusional Modifications Reversibly Alter Aquaporin 5 Expression and Localization in Rat Salivary Glands

2020 ◽  
Vol 11 ◽  
Author(s):  
Eri Saito ◽  
Ippei Watari ◽  
Mariko Mizumachi-Kubono ◽  
Sumire Hsu-Hayashi ◽  
Takashi Ono
Keyword(s):  
Salivary Glands ◽  
Aquaporin 5 ◽  
Rat Salivary Glands

Temporal Reduction in Size of Salivary Acinus in Rats Induced by Theophylline

2005 ◽  
Vol 33 (2) ◽  
pp. 218-224 ◽  
Author(s):  
Satoru Kajikawa ◽  
Ayano Takeuchi ◽  
Aisuke Nii ◽  
Hiroyuki Nakayama ◽  
Kunio Doi
Keyword(s):  
Salivary Glands ◽  
Time Course ◽  
Water Channel ◽  
Phosphodiesterase Inhibitor ◽  
Repeated Administration ◽  
Receptor Activation ◽  
Parotid Glands ◽  
Aquaporin 5 ◽  
Submaxillary Glands ◽  
Immuno Histochemistry

Repeated administration of theophylline, a phosphodiesterase inhibitor, induces the enlargement of the salivary glands in rats. Time-course changes after a single administration of theophylline were examined in the salivary glands, including phosphodiesterase enzyme activity, and the expression of aquaporin 5 (AQP5), a water channel. We also examined the contribution of β-adrenergic receptors to theophylline-induced salivary changes. Male F344 rats were given 50 mg/kg of theophylline intraperitoneally either alone or concurrently with a 10 mg/kg subcutaneous injection of propranolol. After treatment with theophylline alone, the weight and histology of the submaxillary and parotid glands were examined. Phosphodiesterase activity and AQP5 were detected by enzyme- and immuno-histochemistry, respectively. At 4 hours, 8 hours, or both, organ weights were decreased with depletion of secretory vesicles in the acinar cells. In the submaxillary glands, reduced activity of phosphodiesterase and increased expression of AQP5 in the intercalated ducts were observed at 4 hours. When co-administered, propranolol partially abolished theophylline-induced glandular reduction. These results suggest that the theophylline-induced transient reduction in size of the salivary glands is attributable not only to phosphodiesterase inhibition but also to β-adrenergic receptor activation and that the intercalated ducts in submaxillary glands play a role in the production of saliva.

In vivo31P NMR studies of rat salivary glands at 6.3 tesla

1988 ◽  
Vol 8 (2) ◽  
pp. 129-141 ◽  
Author(s):  
A. Heerschap ◽  
J. J. van Vaals ◽  
A. H. Bergman ◽  
J. H. den Boef ◽  
P. H. J. van Gerwen ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Nmr Studies ◽  
Rat Salivary Glands

Ontogeny of guanylin-immunoreactive cells in rat salivary glands

2004 ◽  
Vol 208 (1) ◽  
pp. 65-73 ◽  
Author(s):  
R. Vaccaro ◽  
Y. Cetin ◽  
T. G. Renda
Keyword(s):  
Salivary Glands ◽  
Rat Salivary Glands
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