scholarly journals Expression of Histo-Blood Group A Type 1, 2 and 3 Antigens in Normal Skin and Extramammary Paget’s Disease

2008 ◽  
Vol 41 (6) ◽  
pp. 165-171 ◽  
Author(s):  
Aki Tanaka ◽  
Akihiko Kimura ◽  
Yuki Yamamoto ◽  
Koji Uede ◽  
Fukumi Furukawa
Keyword(s):  
Blood Group ◽  
Normal Skin ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Blood Group A ◽  
Group A ◽  
Extramammary Paget's Disease

scholarly journals NECTIN4 Expression in Extramammary Paget’s Disease: Implication of a New Therapeutic Target

2020 ◽  
Vol 21 (16) ◽  
pp. 5891
Author(s):  
Maho Murata ◽  
Takamichi Ito ◽  
Yuka Tanaka ◽  
Yumiko Kaku-Ito ◽  
Masutaka Furue
Keyword(s):  
Targeted Therapy ◽  
Therapeutic Target ◽  
Normal Skin ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Hair Follicles ◽  
Sweat Glands ◽  
Epidermal Keratinocytes ◽  
Extramammary Paget’S Disease ◽  
Extramammary Paget's Disease

Extramammary Paget’s disease (EMPD) is a rare skin cancer arising in the anogenital area. Most EMPD tumors remain dormant as in situ lesions, but the outcomes of patients with metastatic EMPD are poor because of the lack of effective systemic therapies. Nectin cell adhesion molecule 4 (NECTIN4) has attracted attention as a potential therapeutic target for some cancers. Urothelial cancer is one such cancer, and clinical trials of enfortumab vedotin, a drug-conjugated anti-NECTIN4 antibody, are ongoing. However, little is known regarding the role of NECTIN4 in EMPD. In this study, we conducted immunohistochemical analysis of NECTIN4 expression in 110 clinical EMPD samples and normal skin tissue. In normal skin, positive signals were observed in epidermal keratinocytes (particularly in the lower part of the epidermis), eccrine and apocrine sweat glands, inner and outer root sheaths, and matrix of the hair follicles. The most EMPD lesions exhibited strong NECTIN4 expression, and high NECTIN4 expression was significantly associated with increased tumor thickness, advanced TNM stage, and worse disease-specific survival. These results support the potential use of NECTIN4-targeted therapy for EMPD. Our report contributes to the better understanding of the pathobiology of NECTIN4 in the skin and the skin-related adverse effects of NECTIN4-targeted therapy.

scholarly journals Trop2 Expression in Extramammary Paget’s Disease and Normal Skin

2021 ◽  
Vol 22 (14) ◽  
pp. 7706
Author(s):  
Takamichi Ito ◽  
Keiko Tanegashima ◽  
Yuka Tanaka ◽  
Hiroki Hashimoto ◽  
Maho Murata ◽  
...  
Keyword(s):  
Normal Skin ◽  
Paget’S Disease ◽  
Disease Free Survival ◽  
Paget's Disease ◽  
Hair Follicles ◽  
Surface Glycoprotein ◽  
Epidermal Keratinocytes ◽  
Extramammary Paget’S Disease ◽  
Apocrine Glands ◽  
Extramammary Paget's Disease

Extramammary Paget’s disease (EMPD) is a rare skin cancer arising in the apocrine gland-rich areas. Most EMPD tumors are dormant, but metastatic lesions are associated with poor outcomes owing to the lack of effective systemic therapies. Trophoblast cell surface antigen 2 (Trop2), a surface glycoprotein, has drawn attention as a potential therapeutic target for solid tumors. Sacituzumab govitecan, an antibody–drug conjugate of Trop2, has recently entered clinical use for the treatment of various solid cancers. However, little is known about the role of Trop2 in EMPD. In this study, we immunohistochemically examined Trop2 expression in 116 EMPD tissue samples and 10 normal skin tissues. In normal skin, Trop2 was expressed in the epidermal keratinocytes, inner root sheaths, and infundibulum/isthmus epithelium of hair follicles, eccrine/apocrine glands, and sebaceous glands. Most EMPD tissues exhibited homogeneous and strong Trop2 expression, and high Trop2 expression was significantly associated with worse disease-free survival (p = 0.0343). These results suggest the potential use of Trop2-targeted therapy for EMPD and improve our understanding of the skin-related adverse effects of current Trop2-targeted therapies such as sacituzumab govitecan.

Four cases of extramammary Paget's disease - A topographic study.

1984 ◽  
Vol 46 (5) ◽  
pp. 1118-1122 ◽  
Author(s):  
Yoshihisa FUJII ◽  
Nobuyuki SHIRAISHI ◽  
Etsuji MATSUNAGA ◽  
Susumu TAKAYASU ◽  
Toshitaka NAKAMURA
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Extramammary Paget's Disease

A Case of Extramammary Paget's Disease after Excision of Bilateral Breast Carcinoma

2007 ◽  
Vol 69 (3) ◽  
pp. 273-276
Author(s):  
Satoko KUMAZAWA ◽  
Kou DAN ◽  
Teiichi MASUDA ◽  
Kazunori URABE ◽  
Masutaka FURUE
Keyword(s):  
Breast Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Bilateral Breast Carcinoma ◽  
Extramammary Paget's Disease

Programmed Death-Ligand 1 and Programmed Death-Ligand 2 Expression Can Affect Prognosis in Extramammary Paget’s Disease

2021 ◽  
Vol 41 (1) ◽  
pp. 219-226
Author(s):  
AYA KAWAGUCHI ◽  
JUN AKIBA ◽  
REIICHIRO KONDO ◽  
EIJI SADASHIMA ◽  
SACHIKO OGASAWARA ◽  
...  
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Extramammary Paget's Disease
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