scholarly journals The relationship of 1,25-dihydroxyvitamin D and Vitamin D binding protein in periodontitis

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Sara Rafique ◽  
Mozaffer Rahim Hingorjo ◽  
Mahparah Mumtaz ◽  
Masood Anwar Qureshi
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Healthy Controls ◽  
Vitamin D Binding Protein ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Relationship Of ◽  
The Relationship

Objective: This study was conducted to explore the relationship between 1,25-dihydroxy vitamin D (1,25(OH)2D) and Vitamin-D binding protein (DBP) in patients with periodontitis and healthy controls. Methods: Seventy-five periodontitis cases were recruited from the dental OPD of Dow University of Health Sciences, Karachi. Diagnostic criteria of periodontitis were followed according to the probe pocket depth and clinical attachment loss. Seventy-five periodontal healthy controls were selected from the faculty and students of same university. Serum levels of 1,25(OH)2D and DBP were determined by ELISA. Results: Significantly low levels of 1,25(OH)2D and high levels of serum DBP were observed in periodontitis patients compared to healthy controls (p<0.05), with levels of DBP increasing significantly with the severity of periodontitis (p=0.005). Concentrations of DBP correlated positively with 1,25(OH)2D, especially in cases with periodontitis (r =0.780; p<0.001). Conclusion: Within the limits of the study, we conclude that low 1,25(OH)2D levels and high DBP levels are associated with periodontitis. doi: https://doi.org/10.12669/pjms.35.3.482 How to cite this:Rafique S, Hingorjo MR, Mumtaz M, Qureshi MA. The relationship of 1,25-dihydroxyvitamin D and Vitamin D binding protein in periodontitis. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.482 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Regulation of 1,25-Dihydroxyvitamin D Synthesis by Intracellular Vitamin D Binding Protein-1

Endocrinology ◽  
2002 ◽  
Vol 143 (10) ◽  
pp. 4135-4135 ◽  
Author(s):  
Shaoxing Wu ◽  
Rene Chun ◽  
Mercedes A. Gacad ◽  
Songyang Ren ◽  
Hong Chen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D

1,25-Dihydroxyvitamin D and Vitamin D-Binding Protein Are Both Decreased in Streptozotocin-Diabetic Rats*

Endocrinology ◽  
1985 ◽  
Vol 116 (6) ◽  
pp. 2483-2488 ◽  
Author(s):  
BULANGU L. NYOMBA ◽  
ROGER BOUILLON ◽  
WILLY LISSENS ◽  
HUGO VAN BAELEN ◽  
PIETER DE MOOR
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Diabetic Rats ◽  
Vitamin D Binding Protein ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Streptozotocin Diabetic Rats

scholarly journals Vitamin D-Binding Protein Directs Monocyte Responses to 25-Hydroxy- and 1,25-Dihydroxyvitamin D

2010 ◽  
Vol 95 (7) ◽  
pp. 3368-3376 ◽  
Author(s):  
Rene F. Chun ◽  
Anna L. Lauridsen ◽  
Lizabeth Suon ◽  
Lee A. Zella ◽  
J. Wesley Pike ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D

Calcium-Regulating Hormones and Minerals From Birth to 18 Months of Age: A Cross-Sectional Study. I. Effects of Sex, Race, Age, Season, and Diet on Vitamin D Status

PEDIATRICS ◽  
1986 ◽  
Vol 77 (6) ◽  
pp. 883-890
Author(s):  
P. Lichtenstein ◽  
B. L. Specker ◽  
R. C. Tsang ◽  
F. Mimouni ◽  
C. Gormley
Keyword(s):  
Vitamin D ◽  
Human Milk ◽  
Binding Protein ◽  
Vitamin D Metabolites ◽  
Vitamin D Status ◽  
Vitamin D Binding Protein ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
25 Hydroxyvitamin D

The influence of sex, race, age, season, and diet (cow's milk formula v human milk) on the vitamin D and vitamin D-binding protein status in infants less than 18 months of age was investigated in this crosssectional, prospective study of 198 infants. No differences by sex were observed in serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, or vitamin D-binding protein concentrations. By race, black infants had significantly elevated serum 1,25-dihydroxyvitamin D levels relative to white infants. By age, vitamin D-binding protein concentrations increased with increasing age. By season, serum 25-hydroxyvitamin D concentrations were low in winter, whereas 1,25-dihydroxyvitamin D and vitamin D-binding protein were high in winter compared with summer. By diet, formula-fed infants had higher serum concentrations of all measured vitamin D metabolites and vitamin D-binding protein than human milk-fed infants. Thus, race, age, season, and diet exert, individually or in combination, different and significant effects on vitamin D metabolites; these should be considered in assessing infant vitamin D status.

Plasma concentrations of vitamin D metabolites in pubertal girls with anorexia nervosa

1986 ◽  
Vol 113 (4_Suppl) ◽  
pp. S458-S467 ◽  
Author(s):  
D. AARSKOG ◽  
L. AKSNES ◽  
T. MARKESTAD ◽  
O. TRYGSTAD
Keyword(s):  
Vitamin D ◽  
Anorexia Nervosa ◽  
Binding Protein ◽  
Plasma Concentrations ◽  
Similar Data ◽  
Vitamin D Binding Protein ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
25 Hydroxyvitamin D

ABSTRACT Plasma concentrations of 25-hydroxyvitamin D (25-OHD), 1,25-dihydroxyvitamin D (1,25-(OH)2D), 24,25-dihydroxyvitamin D (24,25-(OH)2D) and vitamin D-binding protein (DBP) were measured in 12 pubertal girls (aged 10-18 yr) with anorexia nervosa in relapse. The results were compared with similar data obtained in 81 healthy girls representing all stages of puberty. The patients with anorexia nervosa had significantly lower 1,25-(OH)2D levels (71 vs. 124 pmol/l; p<0.0005), and significantly higher 24,25-(OH)2D levels (6.0 vs. 3.2 nmol/l; p<0.0005), whereas the 25-OHD concentrations were similar in the two groups (85.7 vs. 86.7 nmol/l). The molar ratios of 24,25-(OH)2D to 25-OHD, which reflects the relative activity of the 24-hydroxylation, were significantly higher in the anorectics (6.6 % vs. 3.6 %; p<0.0005). The mean level of DBP did not differ between the two groups, and accordingly the calculated "free-fraction of 1,25-(OH)2 D" was significantly lower in the anorectic patients (p<0.0005). It appears that the regulatory mechanisms of the vitamin D endocrine system are altered in the patients with anorexia nervosa at puberty resulting in a relative decrease of the plasma concentration of 1,25-(OH)2D and increase of the 24,25-(OH)2D concentration. Key words: Anorexia nervosa, vitamin D metabolism, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, vitamin D binding protein

Sign in / Sign up

Export Citation Format

Share Document