scholarly journals Effects of supervised structured aerobic exercise training program on high and low density lipoprotein in patients with type II diabetes mellitus

2017 ◽  
Vol 33 (1) ◽  
Author(s):  
Syed Shakil Ur Rehman ◽  
Hossein Karimi ◽  
Syed Amir Gilani
Keyword(s):  
Diabetes Mellitus ◽  
Exercise Training ◽  
Type Ii Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Type Ii Diabetes Mellitus ◽  
Aerobic Exercise Training ◽  
Low Density ◽  
Type Ii ◽  
Exercise Training Program

scholarly journals Synergistic Hypoglycemic Effects of Pumpkin Polysaccharides and Puerarin on Type II Diabetes Mellitus Mice

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 955 ◽  
Author(s):  
Xue Chen ◽  
Lei Qian ◽  
Bujiang Wang ◽  
Zhijun Zhang ◽  
Han Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Type Ii Diabetes Mellitus ◽  
Hypoglycemic Effect ◽  
Lipid Lowering ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Type Ii

To investigate the hypoglycemic effect and potential mechanism of pumpkin polysaccharides and puerarin on type II diabetes mellitus (T2DM) mice, mice were fed a high-fat diet and injected intraperitoneally with streptozotacin to induce T2DM. After eight weeks of drug administration, blood samples were withdrawn from tail veins of mice that had been fasted overnight. The results showed that both pumpkin polysaccharides and puerarin, as well as a pumpkin polysaccharides and puerarin combination, could ameliorate T2DM. The pumpkin polysaccharides and puerarin combination had a synergetic hypoglycemic effect on T2DM mice that was greater than the pumpkin polysaccharides’ or the puerarin’s hypoglycemic effect. Both the pumpkin polysaccharides and the puerarin were found to ameliorate the blood glucose tolerance and insulin resistance of T2DM mice. They showed lipid-lowering activity by reducing the total cholesterol, triglycerides, and low-density lipoprotein levels, and improving the high-density lipoprotein level. They had beneficial effects on the oxidative stress by decreasing the reactive oxygen species and malondialdehyde levels, and increasing the glutathione level and the superoxide dismutase activity. Furthermore, the nuclear factor E2 related factor 2 (Nrf2), heme oxygenase-1, and phosphoinositide-3-kinase (PI3K) levels were upregulated, and the Nrf2 and PI3K signalling pathways might be involved in the hypoglycemic mechanism. The combined administration of pumpkin polysaccharides and puerarin could synergistically ameliorate T2DM.

scholarly journals Evaluation of Serum HDL and LDL levels in Type II Diabetes Mellitus

2013 ◽  
Vol 1 (1) ◽  
pp. 21 ◽  
Author(s):  
K R Joshi ◽  
K K Hiremath ◽  
S P Gupta
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Type Ii Diabetes Mellitus ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Type Ii

  Introduction: Diabetes mellitus is a type of metabolic disorder characterized by hyperglycemia resulting from defect in insulin secretion, insulin action or both. This study intended to compare High Density Lipoprotein Cholesterol (HDL) and Low Density Lipoprotein Cholesterol (LDL) profile between type II diabetic and non-diabetic subjects and also find the correlation between HDL and LDL cholesterol in type II diabetic.   Methods: The study was conducted on 100 total subjects out of which experimental group with 50 subjects of known Type II Diabetes mellitus and control group with 50 subjects.   Results: The result of the present study suggests that fasting blood sugar and LDL cholesterol levels were increased but HDL cholesterol level was reduced in type II diabetic subjects when compared to controls.   Conclusion: The estimation of HDL cholesterol and LDL cholesterol in type II diabetes mellitus is very useful as it may serve as a useful parameter to monitor the prognosis of the patient.

scholarly journals A study to assess the predictive value of CRP in detecting type-II diabetes mellitus with nephropathy

2021 ◽  
Vol 12 (1) ◽  
pp. 884-888
Author(s):  
Shashi Prabha Singh ◽  
Pradeep Kumar ◽  
Preeti Sharma ◽  
Rakesh Sharma ◽  
Manish Verma
Keyword(s):  
Diabetes Mellitus ◽  
Sensitivity And Specificity ◽  
Type Ii Diabetes ◽  
Density Lipoprotein ◽  
Diabetes Type 2 ◽  
Type Ii Diabetes Mellitus ◽  
Diabetes Type ◽  
Low Density ◽  
Type Ii

To assess C reactive protein (CRP) in detecting type-II diabetes mellitus with nephropathy. Patients with a history of diabetes type 2 with nephropathy and patients with diabetes type 2 without nephropathy were included in the study. A total of 30 cases, both male and female, were recruited and compared with30 normal healthy adults. Each participant (age, gender, BMI, i.e. body mass index and WHR, i.e. waist-hip ratio) were recorded. CRP was measured by immunoturbidimetric method. Total cholesterol, triglycerides, and high-density lipoprotein (HDL) cholesterol were measured by the CHOD-POD method, GPO-PAP method, and CHOD-POD/phosphotungstic method. Low-density lipoprotein (LDL)cholesterol and very low-density cholesterol were measured by Friedewald formula. Lipoprotein ratios ware also calculated. CRP was significantly (p=0.0001) higher among cases (12.60±3.30) compared to controls (5.47±4.29). CRP >9.5 correctly (efficacy) predicted DM2 with DN among 46.7% cases with sensitivity and specificity of 93.3 (95%CI=84.4-102.3) and 76.7 (95%CI=61.5-91.8) respectively. The area under the curve (AUC) was also high (AUC=0.85, 95%CI=0.75-0.95). There was a poor correlation of CRP with lipid profile among DM-2 with DN. Linear regression analysis showed that lipid biomarkers such as HDL, LDL, VLDL & total cholestarol-to-HDL ratio as well as BMI and WHR were positive predictors of CRP after adjusted for age and sex. In turn, HDL, LDL, VLDL and TC to HDL ratio level were a negative predictive factor of CRP levels. The increase of 1 unit on HDL was associated with a reduction of 1.25 in CRP levels. However, all the predictors had no statistical significance (p>0.05). In this study, the level of CRP was higher among cases compared to controls. This study also found that CRP >9.5 had good sensitivity and specificity in predicting DM2 with DN.

scholarly journals Efficacy and adverse reaction to different doses of atorvastatin in the treatment of type II diabetes mellitus

2019 ◽  
Vol 39 (7) ◽  
Author(s):  
Hua Jiang ◽  
Hong Zheng
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Adverse Reactions ◽  
Density Lipoprotein ◽  
Type Ii Diabetes Mellitus ◽  
Retinol Binding Protein ◽  
Type Ii ◽  
Sprague Dawley ◽  
Rat Serum ◽  
Different Doses

Abstract Background: Type II diabetes mellitus (T2DM), a persistent metabolic disorder, is primarily characterized by insulin resistance, relative insulin deficiency and dyslipidemia. Here, we aimed to investigate whether different doses of atorvastatin (ATV) affect rats with T2DM. A total of 110 Sprague–Dawley rats were successfully established as T2DM models. Methods: First, the total cholesterol, triglyceride (TG), high-/low-/very-low-density lipoprotein cholesterol (HDL-c/LDL-c/VLDL-c), alanine transaminase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine (Cr), apolipoprotein Al (ApoA1) and apolipoprotein B (ApoB) levels in rat serum were analyzed. In addition, cholesteryl ester transfer protein (CETP) and retinol-binding protein 4 (RBP4) were also measured. Then, the incidence of adverse reactions was noted. Finally, the pathological study of liver and pancreatic tissues was performed. Results: Rats administered ATV at the doses of 40 and 80 mg/(kg·day) showed down-regulated TG, LDL-c, ApoB, CETP and RBP4 levels yet up-regulated HDL-c and ApoAl levels. Rats administered ATV at a dose of 80 mg/(kg·day) exhibited a higher incidence of adverse reactions and higher ALT and AST levels but lower BUN and Cr levels, which might affect liver and kidney function. Rats administered ATV at the doses of 40 and 80 mg/(kg·day) demonstrated significantly improved liver injury and pancreatic injury induced by T2DM. Conclusion: These data revealed that ATV could improve the lipid metabolism in T2DM rats and 40 mg/(kg·day) may serve as the optimal dose for the reduction of lipid levels and the incidence of adverse effects.

Paraoxonase-1 (PON-1) genotype and activity and in vivo oxidized plasma low-density lipoprotein in Type II diabetes

2005 ◽  
Vol 109 (2) ◽  
pp. 189-197 ◽  
Author(s):  
Mike J. Sampson ◽  
Simon Braschi ◽  
Gavin Willis ◽  
Sian B. Astley
Keyword(s):  
Type Ii Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Paraoxonase 1 ◽  
Ldl Oxidation ◽  
Phenyl Acetate ◽  
Low Density ◽  
Type Ii

The HDL (high-density lipoprotein)-associated enzyme PON (paraoxonase)-1 protects LDL (low-density lipoprotein) from oxidative modification in vitro, although it is unknown if this anti-atherogenic action occurs in vivo. In a cross-sectional study of 58 Type II diabetic subjects and 50 controls, we examined the fasting plasma LDL basal conjugated diene concentration [a direct measurement of circulating oxLDL (oxidatively modified LDL)], lipoprotein particle size by NMR spectroscopy, PON-1 polymorphisms (coding region polymorphisms Q192R and L55M, and gene promoter polymorphisms −108C/T and −162G/A), PON activity (with paraoxon or phenyl acetate as the substrates) and dietary antioxidant intake. Plasma oxLDL concentrations were higher in Type II diabetic patients (males, P=0.048; females, P=0.009) and unrelated to NMR lipoprotein size, PON-1 polymorphisms or PON activity (with paraoxon as the substrate) in any group. In men with Type II diabetes, however, there was a direct relationship between oxLDL concentrations and PON activity (with phenyl acetate as the substrate; r=0.611, P=0.0001) and an atherogenic NMR lipid profile in those who were PON-1 55LL homozygotes. Circulating oxLDL concentrations in vivo were unrelated to PON-1 genotypes or activity, except in male Type II diabetics where there was a direct association between PON activity (with phenyl acetate as the substrate) and oxLDL levels. These in vivo data contrast with in vitro data, and may be due to confounding by dietary fat intake. Male Type II diabetic subjects with PON-1 55LL homozygosity have an atherogenic NMR lipid profile independent of LDL oxidation. These data do not support an in vivo action of PON on LDL oxidation.

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