scholarly journals Relationship of serum uric acid level and angiographicseverity of coronary artery disease in male patients with acute coronary syndrome

2013 ◽  
Vol 29 (5) ◽  
Author(s):  
Azmat Ehsan Qureshi ◽  
Shahid Hameed ◽  
Ahmed Noeman
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Uric Acid ◽  
Coronary Artery ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Coronary Syndrome ◽  
Male Patients ◽  
Artery Disease ◽  
Relationship Of

scholarly journals A study of angiographic severity in patients with coronary artery disease and hyperuricemia

2015 ◽  
Vol 7 (2) ◽  
pp. 1-4 ◽  
Author(s):  
Subhraprakash Pramanik ◽  
Koushik Mondal ◽  
Arpan Kumar Dey ◽  
Pijush Kanti Mandal ◽  
Shovan Kumar Das ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Uric Acid ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
P Value ◽  
Gensini Score ◽  
Artery Disease

Backgrounds: Hyperuricemia has not yet been established as cardiovascular risk factor. We aimed to study the angiographic severity in patients with coronary artery disease (CAD) and hyperuricemia.Materials and Methods: In this observational cross-sectional study we measured serum uric acid level in 82 patients of CAD who underwent coronary angiography in catheterisation laboratory of our Institution. Severity of CAD was determined on the basis of Gensini score, number of diseased vessels, critical lesions and total occlusions.Results: The prevalence of hyperuricemia in patients with CAD was 42.68% in our study. Hyperuricemia was associated with higher Gensini score (33.33±10.64 vs. 22.90±6.75, p value <0.001), number of critical lesions (1.03±0.84 vs. 0.63±0.72, p value 0.031), total occlusions (0.67±0.47 vs. 0.37±0.48, p value 0.007) and dyslipidemia (63.6% vs. 30.6%, p value 0.003) more frequently compared to normouricemic patients. And also the higher serum uric acid level was correlated with higher Gensini score (beta 0.418, t 4.430, p value <0.001, 95% CI 0.036 and 0.094) and frequent number of total occlusion (beta 0.338, t 3.589, p value 0.001, 95% CI 0.462 and 1.613).Conclusion: Hyperuricemia was associated with higher Gensini score, frequent total occlusions and critical lesions in patients with Coronary Artery Disease compared to patients with normal uric acid level and also it was significantly correlated with higher Gensini score and frequent total occlusions.Asian Journal of Medical Sciences Vol.7(2) 2015 1-4

scholarly journals The association between serum uric acid level and coronary artery disease

2010 ◽  
Vol 64 (7) ◽  
pp. 900-907 ◽  
Author(s):  
O. Sinan Deveci ◽  
G. Kabakci ◽  
S. Okutucu ◽  
E. Tulumen ◽  
H. Aksoy ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Uric Acid ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Artery Disease

scholarly journals Limitations of Cox Proportional Hazards Analysis in Mortality Prediction of Patients with Acute Coronary Syndrome

2015 ◽  
Vol 43 (1) ◽  
pp. 33-48 ◽  
Author(s):  
Magdalena Babińska ◽  
Jerzy Chudek ◽  
Elżbieta Chełmecka ◽  
Małgorzata Janik ◽  
Katarzyna Klimek ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Uric Acid ◽  
Coronary Artery ◽  
Cox Regression ◽  
Proportional Hazard ◽  
Proportional Hazard Assumption ◽  
Risk Of Death ◽  
Coronary Syndrome ◽  
Artery Disease

Abstract The aim of this study was to evaluate the possibility of incorrect assessment of mortality risk factors in a group of patients affected by acute coronary syndrome, due to the lack of hazard proportionality in the Cox regression model. One hundred and fifty consecutive patients with acute coronary syndrome (ACS) and no age limit were enrolled. Univariable and multivariable Cox proportional hazard analyses were performed. The proportional hazard assumptions were verified using Schoenfeld residuals, χ2 test and rank correlation coefficient t between residuals and time. In the total group of 150 patients, 33 (22.0%) deaths from any cause were registered in the follow-up time period of 64 months. The non-survivors were significantly older and had increased prevalence of diabetes and erythrocyturia, longer history of coronary artery disease, higher concentrations of serum creatinine, cystatin C, uric acid, glucose, C-reactive protein (CRP), homocysteine and B-type natriuretic peptide (NT-proBNP), and lower concentrations of serum sodium. No significant differences in echocardiography parameters were observed between groups. The following factors were risk of death factors and fulfilled the proportional hazard assumption in the univariable model: smoking, occurrence of diabetes and anaemia, duration of coronary artery disease, and abnormal serum concentrations of uric acid, sodium, homocysteine, cystatin C and NT-proBNP, while in the multivariable model, the risk of death factors were: smoking and elevated concentrations of homocysteine and NT-proBNP. The study has demonstrated that violation of the proportional hazard assumption in the Cox regression model may lead to creating a false model that does not include only time-independent predictive factors.

High Levels of Serum Uric Acid Predict Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome

Angiology ◽  
2011 ◽  
Vol 63 (6) ◽  
pp. 448-452 ◽  
Author(s):  
Mustafa Duran ◽  
Nihat Kalay ◽  
Mahmut Akpek ◽  
Ozcan Orscelik ◽  
Deniz Elcik ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Uric Acid ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Coronary Syndrome ◽  
Artery Disease
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