scholarly journals Determination of the complete nucleotide sequence and haplotypes in the D-loop region of the mitochondrial genome in the Oriental white stork, Ciconia boyciana.

2000 ◽  
Vol 75 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Yoshihiro Yamamoto ◽  
Koichi Murata ◽  
Hideo Matsuda ◽  
Takahisa Hosoda ◽  
Kazuo Tamura ◽  
...  
2021 ◽  
Vol 22 (9) ◽  
pp. 4594
Author(s):  
Andrea Stoccoro ◽  
Fabio Coppedè

Epigenetic modifications of the nuclear genome, including DNA methylation, histone modifications and non-coding RNA post-transcriptional regulation, are increasingly being involved in the pathogenesis of several human diseases. Recent evidence suggests that also epigenetic modifications of the mitochondrial genome could contribute to the etiology of human diseases. In particular, altered methylation and hydroxymethylation levels of mitochondrial DNA (mtDNA) have been found in animal models and in human tissues from patients affected by cancer, obesity, diabetes and cardiovascular and neurodegenerative diseases. Moreover, environmental factors, as well as nuclear DNA genetic variants, have been found to impair mtDNA methylation patterns. Some authors failed to find DNA methylation marks in the mitochondrial genome, suggesting that it is unlikely that this epigenetic modification plays any role in the control of the mitochondrial function. On the other hand, several other studies successfully identified the presence of mtDNA methylation, particularly in the mitochondrial displacement loop (D-loop) region, relating it to changes in both mtDNA gene transcription and mitochondrial replication. Overall, investigations performed until now suggest that methylation and hydroxymethylation marks are present in the mtDNA genome, albeit at lower levels compared to those detectable in nuclear DNA, potentially contributing to the mitochondria impairment underlying several human diseases.


2004 ◽  
Vol 79 (3) ◽  
pp. 151-163 ◽  
Author(s):  
Naomi Sano ◽  
Atsushi Kurabayashi ◽  
Tamotsu Fujii ◽  
Hiromichi Yonekawa ◽  
Masayuki Sumida

1986 ◽  
Vol 50 (11) ◽  
pp. 2771-2778 ◽  
Author(s):  
Ryuji YAMAGUCHI ◽  
Mahito TERABE ◽  
Kiyoshi MIWA ◽  
Makoto TSUCHIYA ◽  
Hiroshi TAKAGI ◽  
...  

1986 ◽  
Vol 50 (11) ◽  
pp. 2771-2778
Author(s):  
Ryuji Yamaguchi ◽  
Mahito Terabe ◽  
Kiyoshi Miwa ◽  
Makoto Tsuchiya ◽  
Hiroshi Takagi ◽  
...  

2014 ◽  
Vol 93 (3) ◽  
pp. 631-641 ◽  
Author(s):  
EN LI ◽  
XIAOQIANG LI ◽  
XIAOBING WU ◽  
GE FENG ◽  
MAN ZHANG ◽  
...  

2008 ◽  
Vol 421 (1) ◽  
pp. 204-206
Author(s):  
K. G. Skryabin ◽  
A. V. Mardanov ◽  
I. V. Kublanov ◽  
E. A. Bonch-Osmolovskaya ◽  
N. V. Ravin

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