The Role of Food-Drug-Cytochrome P450 Interactions in Breast Cancer

2018 ◽  
Vol 5 ◽  
pp. 25-34 ◽  
Author(s):  
Claudia Relats ◽  
Leila Sadeghi ◽  
Eveline Zbären ◽  
Helena Jenzer
Keyword(s):  
Breast Cancer ◽  
Cytochrome P450 ◽  
Cytochrome P450 Interactions

scholarly journals Role of Cytochrome P450 Polymorphisms on Breast Cancer Treatment

2017 ◽  
Vol 06 (02) ◽  
Author(s):  
Tomal Majumder ◽  
Irfan Sajid ◽  
Hasanul Arif Md ◽  
Zahangir Alam
Keyword(s):  
Breast Cancer ◽  
Cytochrome P450 ◽  
Cancer Treatment ◽  
Breast Cancer Treatment

scholarly journals Breast cancer: Role of pharmacogenetics in tamoxifen therapy

2016 ◽  
Vol 1 (1) ◽  
pp. 10
Author(s):  
Smriti Mishra ◽  
Manish Manish
Keyword(s):  
Breast Cancer ◽  
Cytochrome P450 ◽  
Genetic Polymorphism ◽  
Clinical Outcome ◽  
Tamoxifen Therapy ◽  
Uridine Diphosphate ◽  
Cytochrome P450 2D6 ◽  
Cytochrome P450 3A ◽  
P450 2D6

<p><span>The role of pharmacogenetics in the personalization of tamoxifen therapy has relevance in the management of breast cancer. Since Tamoxifen is a pro-drug, genetic polymorphism in Phase I and Phase II drug metabolizing enzymes involved in the bioconversion of tamoxifen to therapeutically active metabolites is critical in determining therapeutic efficacy and adverse drug reactions of the therapy in breast cancer patients. In this review, the role of pharmacogenetics in the personalization of tamoxifen therapy has been discussed. Since, metabolism of tamoxifen by Cytochrome P450 2D6 is significant in determining the therapeutic efficacy of the drug, most of the clinical evidence on tamoxifen pharmacogenetics have been correlated with cytochrome p450 2D6 genetic polymorphism. However, there is discordance in the clinical data, and one of the reasons is the incomplete analysis of all the alleles of cytochrome p450 2D6. International Tamoxifen Pharmacogenomics Consortium has been formed to assess   the discordance. There are also clinical evidences associating genetic polymorphism in cytochrome P450 3A, 2C9, 2C19, Uridine diphosphate –glucuronosyltransferases and Sulfotransferases with clinical outcome of tamoxifen therapy. However, associations of genetic polymorphism in cytochrome P450 3A, 2C9, 2C19, Uridine diphosphate –glucuronosyltransferases and Sulfotransferases with clinical outcome in populations of different ethnicity are unexplored. Evidences on  the association of genetic polymorphisms and the clinical outcome have been summarized in the Table.  Since cost, statistically significant sample population size, labor and ethical issues are the major concerns of a pharmacogenetic investigation; the significance of bottom-up approach in pharmacogenetics has been discussed.</span></p>

Role of Cytochrome P450 Enzymes in the Maintenance of Breast Cancer Metastasized to the Bone [30D]

2019 ◽  
Vol 133 (1) ◽  
pp. 51S-49S
Author(s):  
Sonal Chaudhari ◽  
Christopher Esteb ◽  
Yu-Ting Chang ◽  
Richard Jones
Keyword(s):  
Breast Cancer ◽  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes

Pharmacogenetics of Clozapine: In Vivo Role of Cytochrome P450 Isoforms and P-Glycoprotein

2008 ◽  
Vol 41 (05) ◽  
Author(s):  
E Jaquenoud-Sirot ◽  
B Knezevic ◽  
G Perla Morena ◽  
P Baumann ◽  
CB Eap
Keyword(s):  
Cytochrome P450 ◽  
P Glycoprotein ◽  
Cytochrome P450 Isoforms

Role of social support and pro-health behaviors in fighting breast cancer

2014 ◽  
Vol 12 (4) ◽  
pp. 278-289
Author(s):  
Krystyna Kurowska ◽  
◽  
Izabela Adamczyk ◽  
Keyword(s):  
Breast Cancer ◽  
Social Support ◽  
Health Behaviors

The treatment of brain metastasis from breast cancer, role of blood-brain barrier disruption and early experience with trastuzumab

Therapy ◽  
2006 ◽  
Vol 3 (1) ◽  
pp. 97-112 ◽  
Author(s):  
Rose Marie Tyson ◽  
Dale F Kraemer ◽  
Matthew A Hunt ◽  
Leslie L Muldoon ◽  
Peter Orbay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Blood Brain Barrier ◽  
Early Experience ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption
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