scholarly journals Relationship Between Composition of Fatty Acid in Platelet Phospholipid Membrane and Markers of Oxidative Stress in Healthy Men and Men After a Myocardial Infarction

2021 ◽  
Vol 27 ◽  
Author(s):  
Inga Bikulčienė ◽  
Neda Garjonytė ◽  
Vytautas Žėkas ◽  
Rėda Matuzevičienė ◽  
Živilė Žymantienė ◽  
...  
2019 ◽  
Vol 25 ◽  
pp. 6405-6416 ◽  
Author(s):  
Inga Bikulčienė ◽  
Orinta Golubevaitė ◽  
Vytautas Žėkas ◽  
Mantas Radzevičius ◽  
Dovilė Karčiauskaitė ◽  
...  

2013 ◽  
Vol 5 (2) ◽  
pp. 46-53 ◽  
Author(s):  
Ijen Bhattacharya ◽  
Rahul Saxena ◽  
Raj Saxena ◽  
Alok Milton Lal

Background: Reactive oxygen species have been identified as mediators of cell injury in a variety of cardiovascular complications including Myocardial Infarction (MI). It is conceivable that vitamin E supplementation can be used therapeutically due to its role in ameliorating antioxidant status and free radicals scavenging activity. Aim: Therefore, the present study was undertaken to assess the markers of oxidative stress i.e. erythrocyte glutathione peroxidase (GSHPx) & malondialdehyde (MDA); plasma vitamin C, E, A and uric acid level in the blood samples of MI patients and to investigate the effect of in-vitro vitamin E supplementation in ameliorating the levels of these antioxidants in the blood sample of MI patients. Material & Method: 60 MI subjects (age group 30-60 years) were taken for the study and 60 healthy individuals served as controls. In-vitro vitamin E supplementation in the blood samples of MI subjects were performed and above mentioned parameters were estimated by using standard methods. Data was compared statistically by using student t-test. Result: Vitamin E supplementation brought about an improved antioxidants status with significantly raised vitamin C, E, A and GSHPx levels (p<0.05, p<0.001), and simultaneously depleted level of erythrocyte MDA (p<0.001) in blood samples of MI subjects. However, plasma uric acid levels remain unaltered (p<0.1). Conclusion: These findings further support the preventive and cardio protective role of vitamin E supplementation in reducing oxidative stress levels in the blood samples of MI patients. DOI: http://dx.doi.org/10.3126/ajms.v5i2.8430 Asian Journal of Medical Science, Volume-5(2) 2014: 46-53


2018 ◽  
Vol 34 (5) ◽  
pp. 471-481 ◽  
Author(s):  
Yang Xuan ◽  
Martin Bobak ◽  
Ankita Anusruti ◽  
Eugène H. J. M. Jansen ◽  
Andrzej Pająk ◽  
...  

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Abdulrahman Yakubu ◽  
Azrina Azlan ◽  
Su Peng Loh ◽  
Sabariah Md Noor

This review article stresses the effective role of dietary fish fillet docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on overweight as a risk factor of cardiovascular disease (CVD) via platelet phospholipid modification. Several reports have demonstrated that saturated fat in overweight evokes systemic inflammation and more importantly predisposes it to cardiovascular disorder. Prospective studies have shown that saturated fat is directly proportional to the level of arachidonic acids (AA), precursor of thromboxane in the platelet phospholipid membrane as omega-6 fatty acid in overweight and obese people. Some literature has demonstrated that omega-3 fatty acid from fish fillet ameliorates inflammation, reduces proinflammatory cytokine, inhibits signaling pathway, and regulates the physical composition of inflammatory leukocytes and free radicals (ROS). Yellow stripe scad (YSS) is a local Malaysian fish that has been shown to contain a comparable level of EPA/DHA content as observed in salmon. This review article will focus on the dietary role of fish fillet that will balance the omega-6 fatty acid/omega-3 fatty acid ratio in platelet phospholipid from YSS to manage and prevent healthy overweight/obesity-related risk factor of CVD and to avoid the risk orthodox drug treatment.


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