scholarly journals Comparative Analysis of Renin-Angiotensin System (RAS)-Related Gene Expression Between Hypertensive and Normotensive Rats

2017 ◽  
Vol 23 ◽  
pp. 20-24 ◽  
Author(s):  
Chad R. Williamson ◽  
Sandhya Khurana ◽  
Phong Nguyen ◽  
Collin J. Byrne ◽  
T.C. Tai
Keyword(s):  
Gene Expression ◽  
Comparative Analysis ◽  
Renin Angiotensin System ◽  
Related Gene ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure

2008 ◽  
Vol 65 (5) ◽  
pp. 742-751 ◽  
Author(s):  
Marcin Zakrzewski-Jakubiak ◽  
Simon de Denus ◽  
Marie-Pierre Dubé ◽  
François Bélanger ◽  
Michel White ◽  
...  
Keyword(s):  
Heart Failure ◽  
Gene Polymorphisms ◽  
Renin Angiotensin System ◽  
Related Gene ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Patients With Heart Failure ◽  
Caucasian Patients

scholarly journals Comparative analysis between the use of renin–angiotensin system antagonists and clinical outcomes of hospitalized patients with COVID-19 respiratory infection

2020 ◽  
Vol 155 (11) ◽  
pp. 473-481 ◽  
Author(s):  
Jorge Martínez-del Río ◽  
Jesús Piqueras-Flores ◽  
Patricia Nieto-Sandoval Martín de la Sierra ◽  
Martín Negreira-Caamaño ◽  
Daniel Águila-Gordo ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Clinical Outcomes ◽  
Respiratory Infection ◽  
Renin Angiotensin System ◽  
Hospitalized Patients ◽  
Angiotensin System ◽  
Renin Angiotensin

Regulation of nonclassical renin-angiotensin system receptor gene expression in the adrenal medulla by acute and repeated immobilization stress

2015 ◽  
Vol 308 (6) ◽  
pp. R517-R529 ◽  
Author(s):  
Regina Nostramo ◽  
Lidia Serova ◽  
Marcela Laukova ◽  
Andrej Tillinger ◽  
Chandana Peddu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adrenal Medulla ◽  
Immobilization Stress ◽  
Receptor Gene ◽  
Renin Angiotensin System ◽  
Mrna Levels ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Catecholamine Biosynthesis ◽  
Receptor Mrna

The involvement of the nonclassical renin-angiotensin system (RAS) in the adrenomedullary response to stress is unclear. Therefore, we examined basal and immobilization stress (IMO)-triggered changes in gene expression of the classical and nonclassical RAS receptors in the rat adrenal medulla, specifically the angiotensin II type 2 (AT2) and type 4 (AT4) receptors, (pro)renin receptor [(P)RR], and Mas receptor (MasR). All RAS receptors were identified, with AT2 receptor mRNA levels being the most abundant, followed by the (P)RR, AT1A receptor, AT4 receptor, and MasR. Following a single IMO, AT2 and AT4 receptor mRNA levels decreased by 90 and 50%, respectively. Their mRNA levels were also transiently decreased by repeated IMO. MasR mRNA levels displayed a 75% transient decrease as well. Conversely, (P)RR mRNA levels were increased by 50% following single or repeated IMO. Because of its abundance, the function of the (P)RR was explored in PC-12 cells. Prorenin activation of the (P)RR increased phosphorylation of extracellular signal-regulated kinase 1/2 and tyrosine hydroxylase at Ser31, likely increasing its enzymatic activity and catecholamine biosynthesis. Together, the broad and dynamic changes in gene expression of the nonclassical RAS receptors implicate their role in the intricate response of the adrenomedullary catecholaminergic system to stress.

scholarly journals 729-1 Modulation of Cardiac Hypertrophy by Blockade of the Renin Angiotensin System: Effects on LVH Regression, Gene Expression, and Survival

1995 ◽  
Vol 25 (2) ◽  
pp. 135A
Author(s):  
Heribert Schunkert ◽  
Günter Bruckschlegel ◽  
Stephan R. Holmer ◽  
Daniela Grimm ◽  
Eckhard P. Kromer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cardiac Hypertrophy ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

M1983 Influences of Renin-Angiotensin System-Related Gene Polymorphisms On Gastric Cancer Risks in Japan

2008 ◽  
Vol 134 (4) ◽  
pp. A-444
Author(s):  
Mitsushige Sugimoto ◽  
Takahisa Furuta ◽  
Chise Kodaira ◽  
Masafumi Nishino ◽  
Mihoko Yamade ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gene Polymorphisms ◽  
Renin Angiotensin System ◽  
Related Gene ◽  
Cancer Risks ◽  
Angiotensin System ◽  
Renin Angiotensin

Albumin inhibits the insulin-mediated ACE2 increase in cultured podocytes

2014 ◽  
Vol 306 (11) ◽  
pp. F1327-F1334 ◽  
Author(s):  
Eva Márquez ◽  
Marta Riera ◽  
Julio Pascual ◽  
María José Soler
Keyword(s):  
Gene Expression ◽  
Angiotensin Ii ◽  
Real Time ◽  
Real Time Pcr ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Filtration Barrier ◽  
Gene And Protein Expression ◽  
Ace2 Gene

Podocytes are key cells in the glomerular filtration barrier with a major role in the development of diabetic nephropathy. Podocytes are insulin-sensitive cells and have a functionally active local renin-angiotensin system. The presence and activity of angiotensin-converting enzyme 2 (ACE2), the main role of which is cleaving profibrotic and proinflammatory angiotensin-II into angiotensin-(1–7), have been demonstrated in podocytes. Conditionally immortalized mouse podocytes were cultured with insulin in the presence and absence of albumin. We found that insulin increases ACE2 gene and protein expression, by real-time PCR and Western blotting, respectively, and enzymatic activity within the podocyte and these increases were maintained over time. Furthermore, insulin favored an “anti-angiotensin II” regarding ACE/ACE2 gene expression balance and decreased fibronectin gene expression as a marker of fibrosis in the podocytes, all studied by real-time PCR. Similarly, insulin incubation seemed to protect podocytes from cell death, studied by a terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay. However, all these effects disappeared in the presence of albumin, which may mimic albuminuria, a main feature of DN pathophysiology. Our results suggest that modulation of renin-angiotensin system balance, fibrosis, and apoptosis by insulin in the podocyte may be an important factor in preventing the development and progression of diabetic kidney disease, but the presence of albuminuria seems to block these beneficial effects.

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