Estimation of 24-h Urine Protein Excretion Using Urine Albumin-to-Creatinine Ratio from an In-Hospital Population

2021 ◽  
Vol 28 ◽  
Author(s):  
Xin Liu ◽  
Yonghong Zhao ◽  
Yunlin Feng
Keyword(s):  
Creatinine Ratio ◽  
Urine Protein ◽  
Urine Albumin ◽  
Urine Protein Excretion ◽  
Protein Excretion ◽  
Hospital Population

scholarly journals Estimation of 24-hour urine protein excretion using urine albumin-to-creatinine ratio

2020 ◽  
Author(s):  
Xin Liu ◽  
Yonghong Zhao ◽  
Daqing Hong ◽  
Yunlin Feng
Keyword(s):  
Prediction Model ◽  
Quantitative Description ◽  
High Accuracy ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
Natural Logarithm ◽  
Urine Albumin ◽  
Urine Protein Excretion ◽  
Protein Excretion ◽  
The Relationship

Abstract Background There is still a lack of quantitative description of the relationship between urine albumin-to-creatinine ratio (ACR) and 24-hour urine protein excretion (24h UPE). We aimed to study the correlation between 24h UPE and urine ACR and develop a prediction model for 24h UPE employing urine ACR. Methods This was a retrospective and observational study. All individuals with same-day urine ACR and 24h UPE tests in Sichuan Provincial People’s Hospital from September 1, 2018 to December 31, 2019 were enrolled in the study. Correlation and agreement between urine ACR and 24h UPE were evaluated. A prediction model of 24h UPE was developed and validated. Results 671 subjects were identified. Urine ACR correlated well with 24h UPE (Pearson’s coefficient after natural logarithm transformation = 0.908; p<0.001) and the agreement was consistently good (overall ICC = 0.938; 95% CI: 0.928-0.947; p<0.001). Our multivariable transform model had good performance (R 2 =0.869) and high accuracy (RMSE=0.690) to estimate 24h UPE less than 10 g/day. Conclusions Urine ACR correlates well with 24h UPE in a general population. Our prediction model is an useful tool for estimating 24h UPE less than 10 g/day, however, 24h UPE is still mandatory in situation when the majority of proteinuria is of tubular origin.

scholarly journals To evaluate the diagnostic value of protein: creatinine ratio in a single voided urine sample for quantitation of proteinuria compared to those of a 24-hour urine sample in patients with preeclampsia

2014 ◽  
Vol 9 (2) ◽  
pp. 45-53
Author(s):  
S Hossain ◽  
A Ghosh ◽  
A Chatterjee ◽  
G Sarkar ◽  
SS Mondal
Keyword(s):  
Urine Sample ◽  
Gold Standard ◽  
Diagnostic Value ◽  
Standard Test ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
Predictive Values ◽  
Urine Protein Excretion ◽  
Protein Excretion ◽  
Gold Standard Test

Objective: This study was done to evaluate the diagnostic value of protein: creatinine ratio in a single voided urine sample for quantitation of proteinuria compared to those of a 24 hour urine sample in patients with preeclampsia. Methods: A prospective simple random sample study was done on the hypertensive pregnant women attending the antenatal clinic or admitted in Department of Obstetrics and Gynaecology. It included all women being evaluated for preeclampsia, regardless of the alerting sign or symptom, suspected severity or co-morbid conditions. The main measures were the urinary protein to urinary creatinine ratio by random (spot) direct measurement and the 24-h urinary protein excretion by a 24-h urine collection. The data obtained was statistically analyzed. Results: Out of the 78 patients with gestational hypertension included in our study 48 patients had significant proteinuria (e”300mg/day). Only 2 patients had proteinuria of the range of greater than 3500mg. Among the patients, 50 had a positive protein: creatinine ratio (e”0.3) while 28 patients had a negative protein: creatinine ratio (<0.3). The P: C ratio was able to correctly identify 44 out of 48 patients with significant proteinuria (when the comparison is made with the gold-standard test; i.e., 24-hour urine protein). It could also identify 24 out of 30 patients without significant proteinuria as compared to the gold-standard test. In this study, the Protein: Creatinine ratio with a sensitivity of 91.67%, a specificity of 80%, positive predictive values 88% and the negative predictive values 85.71%. Conclusions: Our data suggests that the protein: creatinine ratio in single voided urine is a highly accurate test (p value < 0.0000001) for discriminating between insignificant and significant proteinuria. Based on the above findings we conclude that a random urine protein excretion predicts the amount of 24- hour urine protein excretion with high accuracy. This could be a reasonable alternative to the 24-hour urine collection for detection of significant proteinuria in hospitalised pregnant women with suspected preeclampsia. Journal of College of Medical Sciences-Nepal, 2013, Vol-9, No-2, 45-53 DOI: http://dx.doi.org/10.3126/jcmsn.v9i2.9687

scholarly journals Comparative study of 24-hour urinary protein and spot urine protein creatinine ratio in pre-eclamptic women

2021 ◽  
Vol 10 (7) ◽  
pp. 2734
Author(s):  
Rupakala B. M. ◽  
Akshata S. Hiremath
Keyword(s):  
Predictive Value ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Spearman Correlation ◽  
Urine Protein ◽  
Spot Urine ◽  
Medical College ◽  
Urine Protein Excretion ◽  
Protein Excretion ◽  
Urine Specimens

Background: The aim of the study was to evaluate the ability of the random urine P/C ratio to predict significant proteinuria, as well as to introduce a diagnostic test for pre-eclampsia which will avoid the inconvenience and time consumption of 24-hour urine protein collection. The objective of this study was to compare spot urine protein- creatinine ratio with 24-hour urine protein for estimation of proteinuria in pre-eclampsia.Methods: A total of 50 pregnant women with pre-eclampsia were prospectively studied for proteinuria in Rajarajeswari medical college and Hospital Bangalore for a period of 9 months from September 2018 to May 2019. Spot urine specimens for measuring P/C ratio were obtained immediately before 24-hour urine collection. The correlation between the spot urine P/C ratio and urinary protein excretion in the 24-hour collections was examined using the Spearman correlation test.Results: PCR at a cut off value 0.15 g/mmol had sensitivity and specificity of 96.6% and 55% respectively. In prediction of proteinuria of 300 mg/24 hr positive predictive value and negative predictive value 76.3% and 91.6% respectively.Conclusions: We found that there was a strong correlation between 24-hour urine protein excretion and spot urine protein creatinine ratio in pre-eclamptic women. Spot PCR can be used as a reasonable alternative to 24-hour urine protein test which is a cumbersome.

Determination of and correlation between urine protein excretion and urine protein-to-creatinine ratio values during a 24-hour period in healthy horses and ponies

2009 ◽  
Vol 70 (12) ◽  
pp. 1551-1556 ◽  
Author(s):  
Benjamin Uberti ◽  
D. Bernard Eberle ◽  
Barrak M. Pressler ◽  
George E. Moore ◽  
Janice E. Sojka
Keyword(s):  
Creatinine Ratio ◽  
Urine Protein ◽  
Urine Protein Excretion ◽  
Protein Excretion

scholarly journals Comparison of urine protein creatinine ratio and 24 hours urine protein in detecting preeclampsia

2019 ◽  
Vol 14 (2) ◽  
pp. 49-53
Author(s):  
Nesuma Sedhain ◽  
Jageshwor Gautam ◽  
Gehanath Baral
Keyword(s):  
Area Under The Curve ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
Protein Determination ◽  
Cross Sectional ◽  
Spot Urine ◽  
Urine Protein Excretion ◽  
Protein Excretion

Aim: To assess the diagnostic accuracy of spot urine protein-creatinine ratio for detection of proteinuria in Preeclampsia. Methods: Cross Sectional Descriptive Study was conducted in a total of 38 pregnant women in Paropakar Maternity and Women’s Hospital in study period of 3 month. The correlation between protein- creatinine ratio in spot urine samples and urinary protein excretion in 24-hour collections were analyzed. Results: Comparison of 24 hours urinary protein and protein- creatinine ratio in women with preeclampsia shows a significant correlation (r=0.911, p<0.0001). The cut-off protein-creatinine ratios which gave maximum area under the curve for 300mg protein for 24hrs was 0.27 (sensitivity: 94.6%, specificity: 100%, PPV: 100%, NPV: 33.3%); 2000 mg urine protein excretion was 2.1 (sensitivity and specificity of 100%); 3000mg protein excreted for 24hours was 3.0 (sensitivity: 83.3%, specificity: 92.3%, PPV: 83.3%, NPV: 93.3%. Area under the ROC for 24hours urine total protein of >300mg, >2000mg and >3000mg/day were 0.946 (95%CI 0.873-1.019), 1 (95% CI 1.00-1.00) and 0.957 (95%CI 0.897- 1.016) respectively. Conclusions: Spot urine protein-creatinine ratio is as accurate as to 24 hours urine protein determination of proteinuria in Preeclampsia.

Spot urine protein–creatinine ratio and 24-h urine protein excretion: Diagnostic accuracy in women with pre-eclampsia

2014 ◽  
Vol 4 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Nazli Hossain ◽  
Nazeer Khan ◽  
Nusrat Shah ◽  
Tahira Shah ◽  
Sofia Butt ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
Spot Urine ◽  
Urine Protein Excretion ◽  
Protein Excretion
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