scholarly journals Persistent Somatic Symptom Burden and Sleep Disturbance in Patients with COVID-19 During Hospitalization and After Discharge: A Prospective Cohort Study

2021 ◽  
Vol 27 ◽  
Author(s):  
Shujie Huang ◽  
Weitao Zhuang ◽  
Dongya Wang ◽  
Lulu Zha ◽  
Xi Xu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Sleep Disturbance ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Somatic Symptom ◽  
Symptom Burden

What part does sleep disturbance play in post-cancer fatigue? Findings from a prospective cohort study.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 605-605
Author(s):  
B. K. Bennett ◽  
D. Goldstein ◽  
F. M. Boyle ◽  
P. L. De Souza ◽  
N. Wilcken ◽  
...  
Keyword(s):  
Cohort Study ◽  
Sleep Disturbance ◽  
Prospective Cohort Study ◽  
Prospective Cohort

scholarly journals Structural brain networks and functional motor outcome after stroke—a prospective cohort study

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Eckhard Schlemm ◽  
Robert Schulz ◽  
Marlene Bönstrup ◽  
Lutz Krawinkel ◽  
Jens Fiehler ◽  
...  
Keyword(s):  
Cohort Study ◽  
Ischaemic Stroke ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Brain Networks ◽  
Symptom Burden ◽  
Lesion Volume ◽  
Stroke Patients ◽  
Residual Symptom ◽  
Structural Brain

Abstract The time course of topological reorganization that occurs in the structural connectome after an ischaemic stroke is currently not well understood. We aimed to determine the evolution of structural brain networks in stroke patients with motor deficits and relate changes in their global topology to residual symptom burden and functional impairment. In this prospective cohort study, ischaemic stroke patients with supratentorial infarcts and motor symptoms were assessed longitudinally by advanced diffusion MRI and detailed clinical testing of upper extremity motor function at four time points from the acute to the chronic stage. For each time point, structural connectomes were reconstructed, and whole-hemisphere global network topology was quantified in terms of integration and segregation parameters. Using non-linear joint mixed-effects regression modelling, network evolution was related to lesion volume and clinical outcome. Thirty patients were included for analysis. Graph-theoretical analysis demonstrated that, over time, brain networks became less integrated and more segregated with decreasing global efficiency and increasing modularity. Changes occurred in both stroke and intact hemispheres and, in the latter, were positively associated with lesion volume. Greater change in topology was associated with larger residual symptom burden and greater motor impairment 1, 3 and 12 months after stroke. After ischaemic stroke, brain networks underwent characteristic changes in both ipsi- and contralesional hemispheres. Topological network changes reflect the severity of damage to the structural network and are associated with functional outcome beyond the impact of lesion volume.

Napping behavior in adults with episodic migraine: a six-week prospective cohort study

SLEEP ◽  
2021 ◽  
Author(s):  
Angeliki Vgontzas ◽  
Elizabeth Mostofsky ◽  
Kobina Hagan ◽  
Michael Rueschman ◽  
Murray A Mittleman ◽  
...  
Keyword(s):  
Cohort Study ◽  
Sleep Disturbance ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Conditional Logistic Regression ◽  
Onset Time ◽  
Episodic Migraine ◽  
Analgesic Effects ◽  
Headache Onset ◽  
Headache Pain

Abstract Study objectives Patients with migraine commonly endorse napping as a strategy for headache pain relief, but also experience high rates of sleep disturbance. To elucidate the relationship between napping behavior and migraine, we evaluated the association between napping and headache frequency, severity, and intensity among adults with episodic migraine. We also examined the association between daily napping and that night’s sleep. Methods In this six-week prospective cohort study, 97 adults with episodic migraine completed twice-daily headache and sleep electronic diaries and wore a wrist actigraph. We modeled the associations between napping (yes/no) and headaches with conditional logistic regression and daily napping and nighttime sleep with linear regression. Results Over 4,353 study days, participants reported 1,059 headache days and 389 days with naps. More than 80% of participants napped during the study, with mean nap duration of 76.7±62.4 minutes. Naps were more likely to occur on day 2 of headache 35/242 (14.5%) than on non-headache days 279/3294 (8.5%, OR 2.2 [95%CI 1.4,3.4]). Mean nap onset time (14:40h ± 3.3h) was later than headache onset (12:48h ± 5.3h). In adjusted models, napping was associated with an additional 1.1 (95%CI -1.4, 3.6) headache days/month. Naps were not associated with worse self-reported or objective sleep that night. Conclusions Our findings suggest that naps may be an uncommonly used behavioral strategy for prolonged migraine attacks and do not contribute to nightly sleep disturbance. Future studies are needed to examine the acute analgesic effects of daytime napping in patients with migraine.

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