scholarly journals Correlations of Silent Information Regulator of Transcription 1 (SIRT1) Expression, Inflammatory Factors, and Oxidative Stress with Pulmonary Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

2021 ◽  
Vol 27 ◽  
Author(s):  
Xin Zhao ◽  
Yueqin Wu
Keyword(s):  
Oxidative Stress ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Inflammatory Factors ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Sirt1 Expression ◽  
And Oxidative Stress

Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?

2019 ◽  
Vol 219 (9) ◽  
pp. 477-484 ◽  
Author(s):  
W.A. Sepúlveda Loyola ◽  
F. Vilaça Cavallari Machado ◽  
L. Araújo de Castro ◽  
T. Hissnauer Leal Baltus ◽  
N. Rampazzo Morelli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Obstructive Pulmonary Disease ◽  
Metabolic Syndrome ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Disease Severity ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Sequential Treatments with Tongsai and Bufei Yishen Granules Reduce Inflammation and Improve Pulmonary Function in Acute Exacerbation-Risk Window of Chronic Obstructive Pulmonary Disease in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Xiaofan Lu ◽  
Ya Li ◽  
Jiansheng Li ◽  
Haifeng Wang ◽  
Zhaohuan Wu ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Body Temperature ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Bacterial Infections ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Amyloid A ◽  
Sequential Treatments

Background. Sequential treatments of Chinese medicines for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) risk window (RW) have benefits for preventing reoccurrences of AEs; however, the effects on pulmonary function, pulmonary, and systemic inflammatory biomarkers remain unclear.Methods. Cigarette-smoke/bacterial infections induced rats were randomized into Control, COPD, AECOPD, Tongsai Granule/normal saline (TSG/NS), moxifloxacin + salbutamol/NS (MXF+STL/NS), TSG/Bufei Yishen Granule (BYG), MXF+STL/STL, and TSG+MXF+STL/BYG+STL groups and given corresponding medicine(s) in AE- and/or RW phase. Body temperature, pulmonary function, blood cytology, serum amyloid A (SAA) and C-reactive protein (CRP), pulmonary histomorphology and myeloperoxidase (MPO), polymorphonuclear (PMN) elastase, interleukins IL-1β, IL-6, and IL-10, and tumor necrosis factor- (TNF-)αexpressions were determined.Results. Body temperature, inflammatory cells and cytokines, SAA, CRP, and pulmonary impairment were higher in AECOPD rats than stable COPD, while pulmonary function declined and recovered to COPD level in 14–18 days. All biomarkers were improved in treated groups with shorter recovery times of 4–10 days, especially in TSG+MXF+STL/BYG+STL group.Conclusion. Sequential treatments with Tongsai and Bufei Yishen Granules, during AECOPD-RW periods, can reduce inflammatory response and improve pulmonary function and shorten the recovery courses of AEs, especially the integrated Chinese and Western medicines.

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