scholarly journals Polymorphisms in IRF5 and TYK2 Genes Are Associated with Rheumatoid Arthritis in a Chinese Han Population

2020 ◽  
Vol 27 ◽  
Author(s):  
Yuqin Peng ◽  
Bingqian Chen ◽  
Xiaowen Sheng ◽  
Yufeng Qian
Keyword(s):  
Rheumatoid Arthritis ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals The genetic association between TLR-1, -2, -4, and -6 gene polymorphisms and rheumatoid arthritis (RA) susceptibility in a Chinese Han population

2021 ◽  
Keyword(s):  
Rheumatoid Arthritis ◽  
Genetic Association ◽  
Full Text ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Abstract The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.

scholarly journals The Association Between CTLA-4, CD80/86, and CD28 Gene Polymorphisms and Rheumatoid Arthritis: An Original Study and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Weixi Liu ◽  
Zhicheng Yang ◽  
Yan Chen ◽  
Haoyu Yang ◽  
Xiaoxian Wan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Polymorphism ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Costimulatory Molecule ◽  
Functional Class ◽  
Chinese Han Population ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Han Population

Background: Rheumatoid arthritis (RA) is related to several pivotal susceptibility genes, including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes. Although the connection between polymorphisms of CTLA-4 and CD86 genes in different populations of RA have been studied extensively, the results are controversial.Objective: To clarify the correlation in the Chinese Han population between CTLA-4, CD80/86, and CD28 gene polymorphisms, and RA susceptibility.Methods: A case-control study (574 RA patients and 804 controls) was conducted to determine the correlation between CTLA-4 rs231775 and rs16840252 gene polymorphisms, CD86 rs17281995 gene polymorphisms, and the risk of RA for the Chinese Han population. Furthermore, an additional meta-analysis, including three single nucleotide polymorphisms (SNPs) (CTLA-4 rs231775, CTLA-4 rs3087243, and CTLA-4 rs5742909) from 32 citations, including 43 studies, 24,703 cases and 23,825 controls was performed to elucidate the relationship between known SNPs in the CTLA-4 genes and RA for more robust conclusions.Results: The results showed that CTLA-4 rs231775 gene polymorphism decreased the RA risk (GA vs. AA, OR = 0.77, P = 0.025), whereas CTLA-4 rs16840252 and CD86 rs17281995 gene polymorphisms were not related to RA susceptibility. Stratification analyses by RF, ACPA, CRP, ESR, DAS28, and functional class identified significant associations for CTLA-4 rs231775 and rs16840252 gene polymorphisms in the RF-positive and RF-negative groups. A meta-analysis of the literature on CTLA-4 gene polymorphisms and RA risk revealed that the risk of RA was decreased by CTLA-4 rs231775 gene polymorphisms.Conclusions: The CTLA-4 rs231775 gene polymorphism decreased the risk of RA, whereas CTLA-4 rs16840252 and CD86 rs17281995 gene polymorphisms were not related to RA risk. A meta-analysis indicated that CTLA-4 rs231775 and rs3087243 gene polymorphisms decreased the risk of RA. To support these analytical results, additional clinical cases should be investigated in further studies.

scholarly journals Association of the CTLA-4 gene with rheumatoid arthritis in Chinese Han population

2005 ◽  
Vol 13 (7) ◽  
pp. 823-828 ◽  
Author(s):  
Cai Lei ◽  
Zhang Dongqing ◽  
Shi Yeqing ◽  
Martin K Oaks ◽  
Chen Lishan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Association of polymorphisms in pre-miRNA with inflammatory biomarkers in rheumatoid arthritis in the Chinese Han population

2012 ◽  
Vol 73 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Bin Yang ◽  
Jie Chen ◽  
Yi Li ◽  
Junlong Zhang ◽  
Dongdong Li ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chinese Han Population ◽  
Inflammatory Biomarkers ◽  
Chinese Han ◽  
Han Population
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