scholarly journals Chiropractic Therapy Modulated Gut Microbiota and Attenuated Allergic Airway Inflammation in an Immature Rat Model

2020 ◽  
Vol 26 ◽  
Author(s):  
Yan Zhu ◽  
Ying Xiong ◽  
Yun Gu ◽  
Qain Li ◽  
Yu Liu
Keyword(s):  
Gut Microbiota ◽  
Airway Inflammation ◽  
Rat Model ◽  
Allergic Airway Inflammation ◽  
Immature Rat ◽  
Chiropractic Therapy

scholarly journals Soluble corn fiber reduces ovalbumin-induced sinonasal inflammation via the gut microbiota-airway axis

2020 ◽  
Author(s):  
Sierra A. Jaramillo ◽  
Emily M. Borsom ◽  
Gabrielle M. Orsini ◽  
Oliver Kask ◽  
Keehoon Lee ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Airway Inflammation ◽  
Low Socioeconomic Status ◽  
Low Cost ◽  
Allergic Airway Inflammation ◽  
Short Chain Fatty Acids ◽  
Corn Fiber ◽  
Soluble Fiber ◽  
Low Socioeconomic

ABSTRACTAsthma is a chronic airway inflammatory disease that affects approximately 300 million people worldwide, causing a substantial healthcare burden. Although there is a large degree of heterogeneity in the inflammatory response of asthmatics, a subset of patients are characterized by type-2 inflammation, which is in part mediated by TH2 cells in both the upper and lower airways. Asthma prevalence is increased in low-socioeconomic-status populations, where disparities in health behavior exist, including a shift toward a western diet characterized by low dietary fiber. Gut microbes metabolize fiber into short chain fatty acids that can reduce type-2 inflammation in peripheral organs, such as the airways. We hypothesized that soluble fiber can reduce ovalbumin (OVA)-induced upper airway inflammation in the context of the unified airway hypothesis, in mice maintained on ingredient-matched western (WD) and control diets (CD) through production of short chain fatty acids. Our results show that soluble fiber reduces IL-4 and IL-13 gene expression (p<0.05, Mann Whitney) in the sinonasal cavity of CD-fed mice, but this effect was lost in WD-fed mice. This loss of protection in WD-fed mice parallels compositional changes of the cecal and fecal microbiota. Mice fed a soluble fiber supplement while being maintained on a WD had altered microbial communities characterized by lower abundance of fiber fermentering bacteria. This work can be used to develop effective microbiome-based therapeutics as a low-cost method to reduce asthma morbidity.IMPORTANCEPrevious research has supported that western-style diets, typically high-fat and low-fiber, are associated with changes in the gut microbiome and increased inflammation. Western diets are accessible and prominent in low-socioeconomic-status populations, where asthma rates are highest; however, there has yet to be a low-cost asthma therapeutic. For the first time, we investigated whether supplementation with a physiologically relevant quantity of soluble corn fiber can reduce allergic airway inflammation. Our study supports that soluble corn fiber supplementation is associated with compositional shifts of the gut microbiota and reduced airway inflammation, promoting the use of fiber as a low-cost microbiome modifying therapy to reduce asthma-associated inflammation. However, soluble corn fiber in conjunction with a western diet resulted in an alternate gut microbiome composition and loss of protection against allergic airway inflammation. These findings further support the importance of the gut microbiota in host health.

Tetrahydrocurcuminalleviates allergic airway inflammation in asthmatic mice by modulating the gut microbiota

2021 ◽  
Author(s):  
Yinfan Wu ◽  
Yanqiu Chen ◽  
Qin Li ◽  
Xiaoyan Ye ◽  
Xingyue Guo ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Airway Inflammation ◽  
Active Metabolite ◽  
Allergic Inflammation ◽  
Allergic Airway Inflammation ◽  
Dietary Factors

We previously reported that supplementation with dietary tetrahydrocurcumin (THC), the major active metabolite of curcumin (Cur), can improve allergic inflammation in asthmatic mice. Dietary factors can shape the gut microbiota...

Fecal Microbiota Transplantation (FMT) Alleviates Ovalbumin-induced Allergic Airway Inflammation in Neonatal Mice via the PD-1/PD-L1 Axis

2021 ◽  
Author(s):  
Cheng Wu ◽  
Juan Zhang ◽  
Yuan-Yuan Jia ◽  
Xing-Zhi Wang ◽  
Qiu-hong Li ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Airway Inflammation ◽  
Fecal Microbiota Transplantation ◽  
Allergic Airway Inflammation ◽  
Fecal Microbiota ◽  
Cell Death Protein

Abstract Asthma is the common respiratory disorder in children, which is associated with abnormal gut microbiota. Fecal microbiota transplantation (FMT) has successfully ameliorated the symptoms of several diseases and restored the balance of gut microbiota. However, there are few researches about the role of FMT in asthma. This study aimed at exploring whether FMT can alleviate allergic airway inflammation in neonatal mice and elucidating the probable underlying mechanism. A neonatal mouse model of ovalbumin (OVA)-induced allergic asthma was established and transplanted with fecal filtrates. Our results manifested that FMT could protect against the allergic airway inflammation through enhancing mesenteric CD11c + CD103 + DCs and accumulating mucosal Helios + Tregs. Besides, the programmed cell death protein 1/programmed cell death protein 1 ligand (PD-1/PD-L1) signal pathway was inhibited after FMT intervention. Furthermore, this beneficial role of FMT was also associated with the rebalanced gut microbiota, such as Akkermansia. Thus, our findings indicated that FMT intervention could exert a therapeutic effect in a neonatal mouse model of OVA-induced allergic airway inflammation through its remodeling on gut microbiota and regulation of Treg homeostasis via the PD-1/PD-L1 axis, which might be used as an alternative therapy for allergic asthma.

Changes in mucin 1 expression in a rat model of allergic airway inflammation

2018 ◽  
Vol 44 (3) ◽  
pp. 137-142
Author(s):  
Bilal Hasan ◽  
Haimiti Abudulimu ◽  
Li Tian ◽  
Abduxukur Ablimit
Keyword(s):  
Airway Inflammation ◽  
Rat Model ◽  
Allergic Airway Inflammation ◽  
Mucin 1

scholarly journals A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome

Microbiome ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Mateus B. Casaro ◽  
Andrew M. Thomas ◽  
Eduardo Mendes ◽  
Claudio Fukumori ◽  
Willian R. Ribeiro ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Airway Inflammation ◽  
Allergic Inflammation ◽  
Allergic Airway Inflammation ◽  
Allergic Diseases ◽  
Mouse Strains ◽  
Microbial Composition ◽  
Beneficial Effects ◽  
Probiotic Treatment ◽  
Microbiota Diversity

AbstractThe phenotypes of allergic airway diseases are influenced by the interplay between host genetics and the gut microbiota, which may be modulated by probiotics. We investigated the probiotic effects on allergic inflammation in A/J and C57BL/6 mice. C57BL/6 mice had increased gut microbiota diversity compared to A/J mice at baseline. Acetate producer probiotics differentially modulated and altered the genus abundance of specific bacteria, such as Akkermansia and Allistipes, in mouse strains. We induced airway inflammation followed by probiotic treatment and found that only A/J mice exhibited decreased inflammation, and the beneficial effects of probiotics in A/J mice were partially due to acetate production. To understand the relevance of microbial composition colonization in the development of allergic diseases, we implanted female C57BL/6 mice with A/J embryos to naturally modulate the microbial composition of A/J mice, which increased gut microbiota diversity and reduced eosinophilic inflammation in A/J. These data demonstrate the central importance of microbiota to allergic phenotype severity.

Attenuated allergic airway inflammation in Cd39-/- mice

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
M Idzko ◽  
K Ayata ◽  
T Müller ◽  
T Dürk ◽  
M Grimm ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation
Sign in / Sign up

Export Citation Format

Share Document