scholarly journals Role of Sirtuin-1 in Neonatal Hypoxic-Ischemic Encephalopathy and Its Underlying Mechanism

2020 ◽  
Vol 26 ◽  
Author(s):  
Zhen Zhang ◽  
Xin Chen ◽  
Sichen Liu
Keyword(s):  
Underlying Mechanism ◽  
Sirtuin 1 ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy

scholarly journals Role of 20‐HETE in neuronal signaling and contribution to neonatal hypoxic‐ischemic encephalopathy

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Raymond C Koehler ◽  
Zeng-Jin Yang ◽  
Erin L Carter ◽  
Kathleen K Kibler ◽  
Herman Kwansa ◽  
...  
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Neuronal Signaling ◽  
Ischemic Encephalopathy

scholarly journals Prognostic role of acute kidney injury on long-term outcome in infants with hypoxic-ischemic encephalopathy

2019 ◽  
Vol 35 (3) ◽  
pp. 477-483 ◽  
Author(s):  
Francesco Cavallin ◽  
Giulia Rubin ◽  
Enrico Vidal ◽  
Elisa Cainelli ◽  
Luca Bonadies ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hypoxic Ischemic Encephalopathy ◽  
Prognostic Role ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Ischemic Encephalopathy

scholarly journals The Role of Purinergic Signaling in the Pathophysiology of Perinatal Hypoxic-Ischemic Encephalopathy

2020 ◽  
Author(s):  
Tagore M. Morais-Lima ◽  
Joana C. Vicentini ◽  
Anael V.P. Alberto ◽  
Pedro H.M. de Freitas ◽  
Caio M. Perret ◽  
...  
Keyword(s):  
Purinergic Signaling ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy

Role of Carbon Monoxide and Nitric Oxide in Newborn Infants With Postasphyxial Hypoxic-Ischemic Encephalopathy

PEDIATRICS ◽  
2000 ◽  
Vol 106 (6) ◽  
pp. 1447-1451 ◽  
Author(s):  
Y. Shi ◽  
F. Pan ◽  
H. Li ◽  
J. Pan ◽  
S. Qin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Newborn Infants ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy

scholarly journals To evaluate the role of MRI in infants with suspected hypoxic ischemic encephalopathy and prognosticating neurological outcome at end of one year

2017 ◽  
Vol 5 (5) ◽  
pp. 1893
Author(s):  
Shreyas Ramachandran ◽  
Smiti Sripathi
Keyword(s):  
Clinical Outcome ◽  
Motor Development ◽  
Perinatal Asphyxia ◽  
Hypoxic Ischemic Encephalopathy ◽  
Neurological Outcomes ◽  
Common Causes ◽  
One Year ◽  
Ischemic Encephalopathy

Background: Hypoxic ischemic encephalopathy (HIE) is one the common causes of neonatal fatality due to perinatal asphyxia. The long-term outcomes of HIE are impaired mental and motor development, hearing loss, recurrent seizures and cerebral palsy. MRI is increasingly becoming the gold standard in diagnosis of HIE as it involves no radiation and can be performed during a neonates physiological sleep. To evaluate the role of MRI in infants with suspected hypoxic ischemic encephalopathy in prognosticating neurological outcomes at end of one year.Methods: A total of 50 patients were included in the study who underwent MRI of brain. A clinical follow up was done at the end of one year.Results: The sensitivity of MRI in prognosticating clinical outcome was 72% and specificity was 71% while PPV and NPV was 86% and 50% respectively.Conclusions: MRI is a useful modality to assess early changes in HIE and it can prognosticate clinical outcome.

scholarly journals Troponin I Levels in Neonatal Hypoxic–Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental Outcomes

2021 ◽  
Vol 10 (17) ◽  
pp. 4010
Author(s):  
Da-Yang Chen ◽  
Inn-Chi Lee ◽  
Chin-Sheng Yu ◽  
Swee-Hee Wong ◽  
Ko-Huang Lue
Keyword(s):  
Odds Ratio ◽  
Functional Outcomes ◽  
Troponin I ◽  
Cardiac Injury ◽  
Hypoxic Ischemic Encephalopathy ◽  
Short Term ◽  
Neurodevelopmental Outcomes ◽  
Prediction Rate ◽  
Ischemic Encephalopathy

Troponin I is a biomarker for cardiac injury in children. The role of troponin I in neonatal Hypoxic–Ischemic encephalopathy (HIE) may have valuable clinical implications. Troponin I levels were measured within 6 h of birth to determine their relationship to HIE stage, short-term cardiac functional outcomes, and neurodevelopmental outcomes at 1 year. Seventy-three patients were divided into two groups: mild HIE and moderate to severe HIE. Troponin I levels within 6 h of birth were obtained in 61 patients, and were significantly higher in patients with moderate to severe HIE than in patients with mild HIE (Mann–Whitney U test, U = 146, p = 0.001). A troponin I cut-off level of ≥60 pg/mL predicted moderate to severe HIE with a specificity of 81.1% and a negative prediction rate of 76.9%. A troponin I cut-off level of ≥180 pg/mL was significantly (χ2 (1, n = 61) = 33.1, p = 0.001, odds ratio 96.8) related with hypotension during first admission and significantly (χ2 (1, n = 61) = 5.3, p = 0.021, odds ratio 4.53) related with abnormal neurodevelopmental outcomes at 1 year. Early troponin I level may be a useful biomarker for predicting moderate to severe HIE, and initialization of hypothermia therapy.

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