scholarly journals Role of Ca²⁺ in Inhibiting Ischemia-Induced Apoptosis of Parathyroid Gland Cells in New Zealand White Rabbits

2020 ◽  
Vol 26 ◽  
Author(s):  
Wei-han Cao ◽  
Yan-jun Su ◽  
Nian-qiu Liu ◽  
Ying Peng ◽  
Chang Diao ◽  
...  
Keyword(s):  
New Zealand ◽  
Parathyroid Gland ◽  
Gland Cells ◽  
New Zealand White Rabbits ◽  
Induced Apoptosis

scholarly journals The effect of age, anatomical site and bone structure on osteogenesis in New Zealand White rabbit

2015 ◽  
Vol 88 (2) ◽  
Author(s):  
Francesca Ravanetti ◽  
Edoardo Scarpa ◽  
Vittorio Farina ◽  
Marco Zedda ◽  
Carlo Galli ◽  
...  
Keyword(s):  
New Zealand ◽  
Bone Structure ◽  
Skeletal Maturity ◽  
Zealand White Rabbit ◽  
Anatomical Site ◽  
Bone Implants ◽  
New Zealand White Rabbits ◽  
Preclinical Trials ◽  
Parietal Bones

Among animal models, rabbits are widely used in medical research, as they fill the gap between smaller models, commonly employed in basic science, and larger ones, which are better suited for preclinical trials. Given their rapid growth, rabbits provide a valuable system for the evaluation of bone implants for tissue regeneration. By means of a histomorphometric analysis, here we quantified the mineral apposition rates (MARs) in osteonic, periosteum and endosteum osteogenic fronts, of skeletal elements within femur, tibia, radius, ulna, frontal and parietal bones in New Zealand White rabbits aged 6, 7 and 8 months. Our hypothesis is that the MAR varies according to the skeletal maturity of the animal, and also within the skeletal elements and the osteogenic fronts considered. In the present study we show that the MAR in both femur and tibia is significantly higher than in ulna and radius. We also demonstrate that the MAR in parietal bones is significantly higher compared to the MAR of both frontal and forelimb bones. Contrary to what was expected, the MARs of all the skeletal elements considered were not decreased following full skeletal maturity. Finally, the MAR of the osteonic-osteogenic front is the lowest in all of the skeletal elements considered. In conclusion, these results provide new important insights for the evaluation of bone implants, casting a light on the role of both age and osteogenic fronts on the bone MAR, and providing valuable information on the physiological bone turnover in New Zealand White rabbits.

Oleic acid-induced lung injury in rabbits: effect of fibrinogen depletion with Arvin

1988 ◽  
Vol 64 (3) ◽  
pp. 920-928 ◽  
Author(s):  
M. F. Allard ◽  
C. M. Doerschuk ◽  
M. L. Brumwell ◽  
A. Belzberg ◽  
J. C. Hogg
Keyword(s):  
Oleic Acid ◽  
New Zealand ◽  
Lung Injury ◽  
Repair Process ◽  
Elevated Blood ◽  
Lung Water ◽  
Lung Weight ◽  
New Zealand White Rabbits ◽  
Related Proteins

The role of fibrinogen in the evolution of the increased permeability after oleic acid-induced lung injury was studied in New Zealand White rabbits. Animals depleted of fibrinogen by treatment with Malayan pit viper venom were compared with untreated rabbits immediately and at 1 and 24 h after injury. The increased permeability to albumin and elevated extravascular lung water (EVLW) associated with lung injury returned to control values by 24 h in untreated animals. Fibrinogen-depleted animals had a higher mortality (10/25 vs. 2/17, P less than 0.02) and showed a greater immediate increase in permeability to albumin that returned to control values at 1 and 24 h after injury, as well as trends toward elevated blood-free dry lung weight and larger increases in EVLW that persisted for 24 h. These findings indicate that fibrinogen-related proteins play an important role in controlling the microvascular injury that is produced by oleic acid. However, when these proteins are depleted, other mechanisms partially control the leak at later stages of the repair process.

scholarly journals Differential Indicators of Diabetes-Induced Oxidative Stress in New Zealand White Rabbits: Role of Dietary Vitamin E Supplementation

2002 ◽  
Vol 3 (3) ◽  
pp. 185-192 ◽  
Author(s):  
Randall L. Davis ◽  
Christy L. Lavine ◽  
Melissa A. Arredondo ◽  
Patrick McMahon ◽  
Thomas E. Tenner, Jr.
Keyword(s):  
Oxidative Stress ◽  
New Zealand ◽  
Vitamin E ◽  
Antioxidant Enzyme ◽  
Enzyme Activities ◽  
Dietary Vitamin ◽  
Antioxidant Enzyme Activities ◽  
New Zealand White Rabbits ◽  
Vitamin E Supplementation

Determination of reliable bioindicators of diabetes-induced oxidative stress and the role of dietary vitamin E supplementation were investigated. Blood (plasma) chemistries, lipid peroxidation (LPO), and antioxidant enzyme activities were measured over 12 weeks in New Zealand White rabbits (control, diabetic, and diabetic + vitamin E). Cholesterol and triglyceride levels did not correlate with diabetic state. PlasmaLPOwas influenced by diabetes and positively correlated with glucose concentration only, not cholesterol or triglycerides. Liver glutathione peroxidase (GPX) activity negatively correlated with glucose and triglyceride levels. Plasma and erythrocyte GPX activities positively correlated with glucose, cholesterol, and triglyceride concentrations. Liver superoxide dismutase activity positively correlated with glucose and cholesterol concentration. Vitamin E reduced plasma LPO, but did not affect the diabetic state. Thus, plasmaLPOwas the most reliable indicator of diabetes-induced oxidative stress. Antioxidant enzyme activities and types of reactive oxygen species generated were tissue dependent. Diabetes-induced oxidative stress is diminished by vitamin E supplementation.

Experimental craniosynostosis in growing rabbits

1983 ◽  
Vol 58 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Dennis L. Nappen ◽  
Vincent G. Kokich
Keyword(s):  
New Zealand ◽  
The Other ◽  
Coronal Suture ◽  
Content Type ◽  
Metallic Implants ◽  
New Zealand White Rabbits ◽  
Parietal Bones ◽  
Fine Print

✓ Reports on the role of the periosteum in premature sutural synostosis have been contradictory. The present study summarizes a series of six experiments designed to clarify these previously conflicting findings. Twenty-five male New Zealand White rabbits were divided into six experimental groups. In four of the groups, methyl-2-cyanoacrylate was used to glue the frontal and parietal bones together and temporarily immobilize the coronal suture. In the other two groups, the sutures were not immobilized. Polyethylene was used to separate the cyanoacrylate from the periosteum in two of the groups. The experiments were performed at 5 weeks of age, and the animals were killed at either 30, 45, or 180 days postoperatively. Metallic implants were placed in the frontal and parietal bones for monitoring growth and/or sutural immobilization. Sutural fusion was confirmed radiographically or histologically. Based upon the findings it seems that mechanical immobilization of a suture does not induce fusion of that suture in rabbits. Furthermore, it appears that the mere application of methyl-2-cyanoacrylate to the periosteum overlying a suture will consistently cause the formation of a bony bridge in growing rabbits but not in nongrowing animals. The adhesive does not consistently induce synostosis if the periosteum is excised.

A Cytochemical Study of Glucose-6-Phosphatase (G-6-PASE) in Cells Participating in Atherogenesis of Rabbit Aorta

1975 ◽  
Vol 33 ◽  
pp. 460-461
Author(s):  
Sidney D. Kobernick ◽  
Edna A. Elfont ◽  
Neddra L. Brooks
Keyword(s):  
Lipid Metabolism ◽  
New Zealand ◽  
Aortic Wall ◽  
Rabbit Aorta ◽  
Plaque Formation ◽  
Metabolic Changes ◽  
Atherosclerotic Plaques ◽  
Cytochemical Study ◽  
Cellular Alteration ◽  
New Zealand White Rabbits

This cytochemical study was designed to investigate early metabolic changes in the aortic wall that might lead to or accompany development of atherosclerotic plaques in rabbits. The hypothesis that the primary cellular alteration leading to plaque formation might be due to changes in either carbohydrate or lipid metabolism led to histochemical studies that showed elevation of G-6-Pase in atherosclerotic plaques of rabbit aorta. This observation initiated the present investigation to determine how early in plaque formation and in which cells this change could be observed.Male New Zealand white rabbits of approximately 2000 kg consumed normal diets or diets containing 0.25 or 1.0 gm of cholesterol per day for 10, 50 and 90 days. Aortas were injected jin situ with glutaraldehyde fixative and dissected out. The plaques were identified, isolated, minced and fixed for not more than 10 minutes. Incubation and postfixation proceeded as described by Leskes and co-workers.

The role of cbl family of ubiquitin ligases in gastric cancer exosome-induced apoptosis of Jurkat T cells

2009 ◽  
pp. 1-8
Author(s):  
Jing-Lei Qu ◽  
Xiu-Juan Qu ◽  
Ming-Fang Zhao ◽  
Yue-E Teng ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Ubiquitin Ligases ◽  
Jurkat T Cells ◽  
Induced Apoptosis
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