scholarly journals A Model to Predict Treatment Failure of Single‑Dose Methotrexate in Patients with Tubal Pregnancy

2020 ◽  
Vol 26 ◽  
Author(s):  
Si Chen ◽  
Fangfang Zhu ◽  
Yingxuan Zhang ◽  
Jing Li ◽  
Jie Gao ◽  
...  
Keyword(s):  
Single Dose ◽  
Treatment Failure ◽  
Tubal Pregnancy ◽  
Dose Methotrexate ◽  
Predict Treatment Failure

Predictors of treatment failure for ectopic pregnancy treated with single-dose methotrexate

2000 ◽  
Vol 74 (5) ◽  
pp. 877-880 ◽  
Author(s):  
Afaf Tawfiq ◽  
Abdul-Fattah Agameya ◽  
Paul Claman
Keyword(s):  
Single Dose ◽  
Treatment Failure ◽  
Ectopic Pregnancy ◽  
Dose Methotrexate

Rate of Acoustic Neuroma Growth by Volumetric Analysis Preradiation Does Not Predict Treatment Failure

2019 ◽  
Author(s):  
Angela Richardson ◽  
David Mccarthy ◽  
Simon Menaker ◽  
Nagy Elsayyad ◽  
Christine Dinh ◽  
...  
Keyword(s):  
Treatment Failure ◽  
Acoustic Neuroma ◽  
Volumetric Analysis ◽  
Predict Treatment Failure

Severe Pancytopenia Following Single Dose Methotrexate In Psoriasis: A Rare And Potentially Lethal Manifestation

2020 ◽  
Vol 15 ◽  
Author(s):  
Ajeet Singh ◽  
Ritul Choudhary ◽  
Namrata Chhabra ◽  
Satyaki Ganguly ◽  
Vinay Rathore
Keyword(s):  
Single Dose ◽  
Plaque Psoriasis ◽  
Granulocyte Colony Stimulating Factor ◽  
Chronic Plaque Psoriasis ◽  
Toxic Side Effect ◽  
Plaque Erosion ◽  
Dose Methotrexate ◽  
History Of ◽  
Severe Pancytopenia ◽  
Stimulating Factor

: Methotrexate is an antimetabolite anticancer drug frequently used in the treatment of extensive chronic plaque psoriasis. Psoriatic plaque erosion is a rare toxic side effect of single-dose methotrexate and is described as a sign of the impending pancytopenia. Here, we report a case of a 48-year-old male, presented with multiple oral and genital erosions, fissuring over palm and soles for 5 days. His laboratory tests revealed severe pancytopenia and nephropathy. He had a history of chronic plaque psoriasis for which he took a single dose of 15 mg methotrexate. During the hospital stay, the patient needed folate antagonist, granulocyte colony stimulating factor (G-CSF), intravenous fluids, blood transfusions, and platelet transfusions. He recovered within 12 days of admission.

scholarly journals Risk Factors for Failure in Conservatively Treated Osteoporotic Vertebral Fractures: A Systematic Review

2021 ◽  
pp. 219256822098227
Author(s):  
Max J. Scheyerer ◽  
Ulrich J. A. Spiegl ◽  
Sebastian Grueninger ◽  
Frank Hartmann ◽  
Sebastian Katscher ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Treatment Failure ◽  
Patient Specific ◽  
Mineral Density ◽  
Radiographic Findings ◽  
Specific Risk ◽  
Fracture Development ◽  
Predict Treatment Failure

Study Design: Systematic review. Objectives: Osteoporosis is one of the most common diseases of the elderly, whereby vertebral body fractures are in many cases the first manifestation. Even today, the consequences for patients are underestimated. Therefore, early identification of therapy failures is essential. In this context, the aim of the present systematic review was to evaluate the current literature with respect to clinical and radiographic findings that might predict treatment failure. Methods: We conducted a comprehensive, systematic review of the literature according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) checklist and algorithm. Results: After the literature search, 724 potentially eligible investigations were identified. In total, 24 studies with 3044 participants and a mean follow-up of 11 months (range 6-27.5 months) were included. Patient-specific risk factors were age >73 years, bone mineral density with a t-score <−2.95, BMI >23 and a modified frailty index >2.5. The following radiological and fracture-specific risk factors could be identified: involvement of the posterior wall, initial height loss, midportion type fracture, development of an intravertebral cleft, fracture at the thoracolumbar junction, fracture involvement of both endplates, different morphological types of fractures, and specific MRI findings. Further, a correlation between sagittal spinal imbalance and treatment failure could be demonstrated. Conclusion: In conclusion, this systematic review identified various factors that predict treatment failure in conservatively treated osteoporotic fractures. In these cases, additional treatment options and surgical treatment strategies should be considered in addition to follow-up examinations.

Resistance-guided treatment of Mycoplasma genitalium infection at a UK sexual health centre

2021 ◽  
pp. 095646242098776
Author(s):  
Ruairi JH Conway ◽  
Seamus Cook ◽  
Cassandra Malone ◽  
Simon Bone ◽  
Mohammed Osman Hassan-Ibrahim ◽  
...  
Keyword(s):  
Single Dose ◽  
Confidence Interval ◽  
Sexual Health ◽  
Treatment Failure ◽  
Inflammatory Disease ◽  
Health Centre ◽  
Mycoplasma Genitalium ◽  
Macrolide Resistance ◽  
Fluoroquinolone Resistance ◽  
Treatment Failure Rate

We evaluated the ResistancePlus® MG assay in providing macrolide resistance-guided treatment (RGT) for Mycoplasma genitalium infection at a UK sexual health centre. M. genitalium–positive samples from men with urethritis and women with pelvic inflammatory disease (PID) were tested for macrolide resistance–mediating mutations (MRMMs). MRMM-positive infections were given moxifloxacin 400 mg; otherwise 2 g azithromycin (1 g single dose and then 500 mg OD) was given. Among 57  M. genitalium–positive patients (32 men and 25 women), MRMMs were detected in 41/57 (72% [95% confidence interval (95% CI) 58–83%). Thirty-two of 43 patients given RGT attended for test of cure. Treatment failure rate was significantly lower at 1/32 (3%) than 10/37 (27%) before RGT ( n = 37 [men = 23 and women = 17]; p = 0.008). Treatment failure was lower in male urethritis (0/15 vs. 7/21 p = 0.027) but not in female PID. There was a trend of a shorter time to negative test of cure (TOC) in male urethritis (55.1 [95% 43.7–66.4] vs. 85.1 [95% CI CI 64.1–106.0] days, p = 0.077) but not in female PID. Macrolide resistance is higher than previous UK reports and higher than expected. RGT reduces overall treatment failure and is particularly beneficial in M. genitalium urethritis. Fluoroquinolone resistance will continue to rise with increasing fluoroquinolone use, and RGT is critical to direct appropriate azithromycin use and prevent overuse of moxifloxacin.

scholarly journals Molecular disease monitoring using circulating tumor DNA in myelodysplastic syndromes

Blood ◽  
2017 ◽  
Vol 129 (12) ◽  
pp. 1685-1690 ◽  
Author(s):  
Paul Yeh ◽  
Michael Dickinson ◽  
Sarah Ftouni ◽  
Tane Hunter ◽  
Devbarna Sinha ◽  
...  
Keyword(s):  
Treatment Failure ◽  
Myelodysplastic Syndromes ◽  
Circulating Tumor Dna ◽  
Driver Mutations ◽  
Disease Monitoring ◽  
Key Points ◽  
Tumor Dna ◽  
Predict Treatment Failure

Key PointsCirculating tumor DNA can monitor disease and predict treatment failure by tracking driver mutations and karyotypic abnormalities in MDS.

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