scholarly journals Platelet to Lymphocyte Ratio and Glucocorticoid Resistance in Newly Diagnosed Primary Immune Thrombocytopenia: A Retrospective Cohort Study

2019 ◽  
Vol 25 ◽  
pp. 7321-7331
Author(s):  
Lin-Hui Wang ◽  
Chi Chen ◽  
Qing Wang ◽  
Jun Song ◽  
Jun Cao ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Immune Thrombocytopenia ◽  
Glucocorticoid Resistance ◽  
Newly Diagnosed ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Primary Immune Thrombocytopenia

scholarly journals Prognostic value of lymphocyte-to-monocyte ratio and neutrophil-to-lymphocyte ratio in follicular lymphoma: a retrospective cohort study

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e017904 ◽  
Author(s):  
Shing Fung Lee ◽  
Miguel Angel Luque-Fernandez
Keyword(s):  
Cohort Study ◽  
Prognostic Factors ◽  
Follicular Lymphoma ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
International Prognostic Index ◽  
Prognostic Index ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Lymphocyte To Monocyte Ratio

ObjectivesThe clinical course and prognosis of follicular lymphoma (FL) are diverse and associated with the patient’s immune response. We investigated the lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) as prognostic factors in patients with FL, including those receiving radiotherapy.DesignA retrospective cohort study.SettingRegional cancer centre in Hong Kong.Participants88 patients with histologically proven FL diagnosed between 2000 and 2014.Materials and methodsThe best LMR and NLR cut-off values were determined using cross-validated areas under the receiver operating characteristic curves. The extent to which progression-free survival (PFS) and overall survival differed by NLR and LMR cut-off values was assessed using Kaplan-Meier analysis and log-rank tests. A Cox proportional hazards model was fitted to adjust for confounders.ResultsThe best cut-off values for LMR and NLR were 3.20 and 2.18, respectively. The 5-year PFS was 73.6%. After multivariate adjustment, high LMR (>3.20) at diagnosis was associated with superior PFS, with a HR of 0.31 (95% CI 0.13 to 0.71), whereas high NLR at relapse was associated with poorer postprogression survival (HR 1.24, 95% CI 1.04 to 1.49).ConclusionsBaseline LMR and NLR at relapse were shown to be independent prognostic factors in FL. LMR and NLR are cheap and widely available biomarkers that could be used in combination with the Follicular Lymphoma International Prognostic Index by clinicians to better predict prognosis.

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