scholarly journals Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression

2019 ◽  
Vol 25 ◽  
pp. 5795-5800 ◽  
Author(s):  
Wenjuan Cui ◽  
Guoxin Hu ◽  
Jin Peng ◽  
Lin Mu ◽  
Jian Liu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Protein Expression ◽  
Rat Model ◽  
High Mobility ◽  
Reactive Oxygen ◽  
High Mobility Group ◽  
Oxygen Species ◽  
Protective Effects ◽  
Hmgb1 Protein

scholarly journals High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry

2018 ◽  
Vol 294 (6) ◽  
pp. 1915-1923 ◽  
Author(s):  
Susie Son ◽  
Laura E. Bowie ◽  
Tamara Maiuri ◽  
Claudia L. K. Hung ◽  
Carly R. Desmond ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
High Mobility ◽  
Reactive Oxygen ◽  
High Mobility Group ◽  
Oxygen Species ◽  
Nuclear Entry

scholarly journals PCV2 Induces Reactive Oxygen Species To Promote Nucleocytoplasmic Translocation of the Viral DNA Binding Protein HMGB1 To Enhance Its Replication

2020 ◽  
Vol 94 (13) ◽  
Author(s):  
Renjie Sun ◽  
Siqi Sun ◽  
Yikai Zhang ◽  
Yingshan Zhou ◽  
Ying Shan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Ethyl Pyruvate ◽  
High Mobility ◽  
Reactive Oxygen ◽  
Porcine Circovirus Type ◽  
Pcv2 Infection ◽  
Porcine Circovirus ◽  
Oxygen Species ◽  
Hmgb1 Protein ◽  
Pcv2 Replication

ABSTRACT Porcine circovirus type 2 (PCV2) is an important swine pathogen that causes significant economic losses to the pig industry. PCV2 interacts with host cellular factors to regulate its replication. High-mobility-group box 1 (HMGB1) protein, a major nonhistone protein in the nucleus, was recently discovered to participate in viral infections. Here, we demonstrate that nuclear HMGB1 negatively regulated PCV2 replication as shown by overexpression of HMGB1 or blockage of its nucleocytoplasmic translocation with ethyl pyruvate. The B box domain was essential in restricting PCV2 replication. Nuclear HMGB1 restricted PCV2 replication by sequestering the viral genome via binding to the Ori region. However, PCV2 infection induced translocation of HMGB1 from cell nuclei to the cytoplasmic compartment. Elevation of reactive oxygen species (ROS) induced by PCV2 infection was closely associated with cytosolic translocation of nuclear HMGB1. Treatment of PCV2-infected cells with ethyl pyruvate or N-acetylcysteine downregulated PCV2-induced ROS production, suppressed nucleocytoplasmic HMGB1 translocation, and decreased PCV2 replication. Collectively, these findings offer new insight into the mechanism of the PCV2 evasion strategy: PCV2 manages to escape restriction of its replication by nuclear HMGB1 by inducing ROS to trigger the nuclear-to-cytoplasmic translocation of HMGB1. IMPORTANCE Porcine circovirus type 2 (PCV2) is a small DNA virus that depends heavily on host cells for its infection. This study reports the close relationship between subcellular localization of host high-mobility-group box 1 (HMGB1) protein and viral replication during PCV2 infection. Restriction of PCV2 replication by nuclear HMGB1 is the early step of host defense at the host-pathogen interface. PCV2 then upregulates host reactive oxygen species (ROS) to prevent sequestration of its genome by expelling nuclear HMGB1 into the cytosol. It will be interesting to study if a similar evasion strategy is employed by other circoviruses such as beak and feather disease virus, recently discovered PCV3, and geminiviruses in plants. This study also provides insight into the justification and pharmacological basis of antioxidants as an adjunct therapy in PCV2 infection or possibly other diseases caused by the viruses that deploy the ROS-HMGB1 interaction favoring their replication.

Protective effects of Brazilian native fruits against reactive oxygen species

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
J Infante ◽  
A Massarioli ◽  
PL Rosalen ◽  
S Alencar
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Protective Effects
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