scholarly journals Human Papillomavirus Status in Primary Lesions and Pelvic Lymph Nodes and Its Prognostic Value in Cervical Cancer Patients with Lymph Node Metastases

2019 ◽  
Vol 25 ◽  
pp. 1894-1902
Author(s):  
Peng Chen ◽  
Weiyuan Zhang ◽  
Dong Yang ◽  
Weiyang Zhang ◽  
Si Gao
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Prognostic Value ◽  
Pelvic Lymph Nodes ◽  
Node Metastases

Additional value of MR/PET fusion compared with PET/CT in the detection of lymph node metastases in cervical cancer patients

2009 ◽  
Vol 45 (12) ◽  
pp. 2103-2109 ◽  
Author(s):  
Seok-Ki Kim ◽  
Hyuck Jae Choi ◽  
Sang-Yoon Park ◽  
Ho-Young Lee ◽  
Sang-Soo Seo ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Pet Ct ◽  
Node Metastases ◽  
Additional Value

Genomic heritage of sentinel lymph node metastases: Implications for clinical management of breast cancer patients

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 571-571
Author(s):  
D. L. Ellsworth ◽  
R. E. Ellsworth ◽  
T. E. Becker ◽  
B. Deyarmin ◽  
H. L. Patney ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Molecular Mechanisms ◽  
Breast Cancer Patients ◽  
Sentinel Nodes ◽  
Axillary Nodes ◽  
Node Metastases

571 Background: Sentinel lymph node (SLN) biopsy status is a key prognostic factor for breast cancer patients. Sentinel nodes are believed to receive early disseminating cells from the primary tumor, but little is known about the origin of metastases colonizing the sentinel nodes. We used allelic imbalance (AI) to examine genomic relationships among metastases in the sentinel and non-sentinel axillary lymph nodes from complete axillary dissections in 15 patients with lymph node positive breast cancer. Methods: Sentinel nodes were localized by standard scintigraphic and gamma probe techniques using 1.0 mCi technetium-99m sulfur colloid. Pathologically positive nodes were identified by H&E histology and immunohistochemistry. Primary breast tumors and metastases in sentinel and axillary nodes were isolated by laser microdissection. AI was assessed at 26 chromosomal regions and used to examine the timing and molecular mechanisms of metastatic spread to the sentinel and axillary nodes. Results: Overall AI frequencies were significantly higher (p<0.05) in primary breast tumors compared to lymph node metastases. A high level of discordance was observed in patterns and frequencies of AI events between metastases in the sentinel and non-sentinel axillary nodes. Phylogenetic analyses showed that 1) multiple genetically-divergent lineages of metastatic cells independently colonize the lymph nodes; 2) some lymph node metastases appeared to acquire metastatic potential early in tumorigenesis, while other metastases evolved later; and 3) importantly, lineages colonizing the sentinel nodes appeared to originate at different times and to progress by different molecular mechanisms. Conclusions: Genomic diversity and timing of metastatic nodal spread may be important factors in determining outcomes of breast cancer patients. Metastases colonizing the sentinel nodes appear to arise at different times during disease progression and may not be descendants of progenitor cells that colonize the lymph nodes early in tumorigenesis. Metastatic growth in the sentinel nodes thus may be a consequence of stimulating factors from the primary tumor that affect proliferation of previously disseminated cells rather than the timing of metastatic spread. No significant financial relationships to disclose.

Risk of internal mammary lymph node metastases and its prognostic value in breast cancer patients

1993 ◽  
Vol 52 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Masakuni Noguchi ◽  
Nagayoshi Ohta ◽  
Michael Thomas ◽  
Hirohisa Kitagawa ◽  
Itsuo Miyazaki
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Prognostic Value ◽  
Breast Cancer Patients ◽  
Internal Mammary Lymph Node ◽  
Internal Mammary ◽  
Node Metastases
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