scholarly journals RNA-Binding Motif 4 (RBM4) Suppresses Tumor Growth and Metastasis in Human Gastric Cancer

2019 ◽  
Vol 25 ◽  
pp. 4025-4034 ◽  
Author(s):  
Hongmei Yong ◽  
Wei Zhao ◽  
Xueyi Zhou ◽  
Zhenyun Liu ◽  
Qi Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Rna Binding ◽  
Binding Motif ◽  
Human Gastric Cancer ◽  
Tumor Growth And Metastasis

scholarly journals Limited Value of KAI1/CD82 Protein Expression as a Prognostic Marker in Human Gastric Cancer

2012 ◽  
Vol 32 (6) ◽  
pp. 337-342 ◽  
Author(s):  
Maximilian Knoener ◽  
Till Krech ◽  
Florian Puls ◽  
Ulrich Lehmann ◽  
Hans Kreipe ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Expression ◽  
Tumor Growth ◽  
Prognostic Marker ◽  
Metastatic Lymph Node ◽  
Surface Glycoprotein ◽  
Human Gastric Cancer ◽  
Cell Surface Glycoprotein ◽  
Gastric Carcinomas ◽  
Tumor Growth And Metastasis

The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n= 271) with amean clinical follow-up time of 48months were immunostained using the monoclonal anti-KAI1/CD82 antibody G2. Staining was evaluated as negativeversuspositive for statistical analysis. KAI1/CD82 immunoreactivity was absent in 103/271 (38%) cases. There was a trend towards KAI1/CD82 negativity in poorly differentiated cases (p= 0.0679). Moreover, KAI1/CD82-negative carcinomas were associated with a higher pT status (p= 0.0222), metastatic lymph node involvement (p= 0.0018) and a higher clinical tumor stage (p= 0.0050). The median overall survival times of KAI1/CD82-negative and KAI1/CD82-positive gastric carcinomas were 20 and 37 months, respectively (p= 0.2305). These results are in line with the proposed function of KAI1/CD82 as a suppressor of tumor growth and metastasis. However, these data suggest that KAI1/CD82, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer in routine histological workup.

scholarly journals Interleukin-23A is associated with tumor growth in Helicobacter-pylori-related human gastric cancer

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Changming Liu ◽  
Ying Zhang ◽  
Jie Zhan ◽  
Yuanyuan Zhao ◽  
Qijun Wan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Tumor Growth ◽  
Human Gastric Cancer

scholarly journals Morusin inhibits cell proliferation and tumor growth by down-regulating c-Myc in human gastric cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (34) ◽  
pp. 57187-57200 ◽  
Author(s):  
Feng Wang ◽  
Dunke Zhang ◽  
Jingxin Mao ◽  
Xiao-Xue Ke ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Tumor Growth ◽  
Human Gastric Cancer

scholarly journals Loss of MTUS1 in gastric cancer promotes tumor growth and metastasis

Neoplasma ◽  
2014 ◽  
Vol 61 (02) ◽  
pp. 128-135 ◽  
Author(s):  
X. Li ◽  
H. Liu ◽  
T. Yu ◽  
Z. Dong ◽  
L. Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Tumor Growth And Metastasis
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