scholarly journals Therapeutic Effects of Sleeve Gastrectomy and Ileal Transposition on Type 2 Diabetes in a Non-Obese Rat Model by Regulating Blood Glucose and Reducing Ghrelin Levels

2019 ◽  
Vol 25 ◽  
pp. 3417-3424
Author(s):  
Hui Wang ◽  
Xinxin Fa ◽  
Wei Qu ◽  
Jindong Fu ◽  
Kaiyun Fan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Sleeve Gastrectomy ◽  
Blood Glucose ◽  
Rat Model ◽  
Therapeutic Effects ◽  
Ileal Transposition

Diverted sleeve gastrectomy with ileal transposition in overweight, obese, and morbidly obese patients with type 2 diabetes: results of 1-year follow-up

2016 ◽  
Vol 12 (3) ◽  
pp. 541-549 ◽  
Author(s):  
Alper Celik ◽  
Eylem Cagiltay ◽  
Surendra Ugale ◽  
Muharrem Asci ◽  
Bahri Onur Celik ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Sleeve Gastrectomy ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Ileal Transposition

scholarly journals Remodeling Intestinal Flora with Sleeve Gastrectomy in Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Xiaofei Huang ◽  
Pan Weng ◽  
Huixin Zhang ◽  
Yingli Lu
Keyword(s):  
Type 2 Diabetes ◽  
Sleeve Gastrectomy ◽  
Blood Glucose ◽  
Glucose Metabolism ◽  
Fasting Blood Glucose ◽  
Blood Glucose Control ◽  
Intestinal Flora ◽  
Diabetic Rats ◽  
Sham Operation

Objective. As a complicated symbiotic system, intestinal flora is reported closely related to the development of type 2 diabetes recently. Sleeve gastrectomy is one of the approaches of bariatric surgery and could improve blood glucose control in type 2 diabetes patients. This study was to explore the relationship between remodeled intestinal flora and glucose metabolism in diabetic rats.Methods. 20 male diabetic rats were operated; 10 of them underwent sleeve gastrectomy, and 10 of them underwent sham operation. Meanwhile 10 male normal rats underwent sleeve gastrectomy as control. The animals’ weight and FBG had been measured. The composition changes of intestinal flora were detected by 16S rDNA sequence analysis.Results. In diabetic rats, weight and fasting blood glucose decreased significantly after sleeve gastrectomy. However, there was no significant change for weight and blood glucose in normal rats after operation. The intestinal flora of diabetic rats reduced in the proportion of Firmicutes and increased in the proportion of Bacteroidetes after sleeve gastrectomy.Conclusion. The change of dominant microorganisms in intestinal flora might play an important role in the glucose metabolism.

Type 2 Diabetes Control in a Nonobese Rat Model Using Sleeve Gastrectomy with Duodenal–Jejunal Bypass (SGDJB)

2012 ◽  
Vol 22 (12) ◽  
pp. 1865-1873 ◽  
Author(s):  
Dong Sun ◽  
Shaozhuang Liu ◽  
Guangyong Zhang ◽  
Weijie Chen ◽  
Zhibo Yan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Sleeve Gastrectomy ◽  
Rat Model ◽  
Diabetes Control ◽  
Jejunal Bypass

scholarly journals ID: 1014 Expanded autologous adipose derived stem cell transplantation for type 2 diabetes mellitus

2017 ◽  
Vol 4 (S) ◽  
pp. 88
Author(s):  
Phuong Thi-Bich Le ◽  
Phuc Van Pham ◽  
Ngoc Bich Vu ◽  
Loan Thi-Tung Dang ◽  
Ngoc Kim Phan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Stem Cell ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Therapeutic Effects ◽  
Adipose Derived Stem Cell

Introduction: Type 2 diabetes mellitus (T2D) is the most common form of diabetes mellitus, accounting for 90% of diabetes mellitus in patients. At the present time, although T2D can be treated by various drugs and therapies using insulin replacement, reports have shown that complications including microvascular, macrovascular complications and therapy resistance can occur in patients on long term treatment. Stem cell therapy is regarded as a promising therapy for diabetes mellitus, including T2D. The aim of this study was to evaluate the safety and therapeutic effect of expanded autologous adipose derived stem cell (ADSC) transplantation for T2D treatment; the pilot study included 3 patients who were followed for 3 months. Methods: The ADSCs were isolated from stromal vascular fractions, harvested from the belly of the patient,and expanded for 21 days per previously published studies. Before transplantation, ADSCs were evaluated for endotoxin, mycoplasma contamination, and karyotype. All patients were transfused with ADSCs at 1-2x106 cells/kg of body weight.Patients were evaluated for criteria related to transplantation safety and therapeutic effects; these included fever, blood glucose level before transplantation of ADSCs, and blood glucose level after transplantation (at 1, 2 and 3 months). Results: The results showed that all samples of ADSCs exhibited the MSC phenotype with stable karyotype (2n=46), there was no contamination of mycoplasma, and endotoxin levels were low (<0.25 EU/mL). No adverse effects were detected after 3 months of transplantation. Decreases of blood glucose levels were recorded in all patients. Conclusion: The findings from this initial study show that expanded autologous ADSCs may be a promising treatment for T2D.

scholarly journals Metabolic and Hormonal Changes after Sleeve Gastrectomy and Mini Gastric Bypass in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity

Chirurgia ◽  
2019 ◽  
Vol 114 (6) ◽  
pp. 732 ◽  
Author(s):  
Laurian Stoica ◽  
Amadeus Dobrescu ◽  
Alexandru Isaic ◽  
Gabriel Verdeş ◽  
Cristi Tarţa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Gastric Bypass ◽  
Type 2 Diabetes Mellitus ◽  
Sleeve Gastrectomy ◽  
Rat Model ◽  
Mini Gastric Bypass ◽  
Hormonal Changes

scholarly journals Expanded autologous adipose derived stem cell transplantation for type 2 diabetes mellitus

2016 ◽  
Vol 3 (12) ◽  
pp. 1034 ◽  
Author(s):  
Phuong Thi-Bich Le ◽  
Phuc Van Pham ◽  
Ngoc Bich Vu ◽  
Loan Thi-Tung Dang ◽  
Ngoc Kim Phan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Stem Cell ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Therapeutic Effects ◽  
Adipose Derived Stem Cell

Introduction: Type 2 diabetes mellitus (T2D) is the most common form of diabetes mellitus, accounting for 90% of diabetes mellitus in patients. At the present time, althoughT2D can be treated by various drugs and therapies using insulin replacement, reports have shown that complications including microvascular, macrovascular complications and therapy resistance can occur in patients on long term treatment. Stem cell therapy is regarded as a promising therapy for diabetes mellitus, including T2D. The aim of this study was to evaluate the safety and therapeutic effect of expanded autologous adipose derived stem cell (ADSC) transplantation for T2D treatment; the pilot study included 3 patients who were followed for 3 months. Methods: The ADSCs were isolated from stromal vascular fractions, harvested from the belly of the patient,and expanded for 21 days per previously published studies. Before transplantation, ADSCs were evaluated for endotoxin, mycoplasma contamination, and karyotype.All patients were transfused with ADSCs at 1-2x106 cells/kg of body weight.Patients were evaluated for criteria related to transplantation safety and therapeutic effects; these included fever, blood glucose level before transplantation of ADSCs, and blood glucose level after transplantation (at 1, 2 and 3 months).Results: The results showed that all samples of ADSCs exhibited the MSC phenotype with stable karyotype (2n=46), there was no contamination of mycoplasma, and endotoxin levels were low (0.25 EU/mL). No adverse effects were detected after 3 months of transplantation. Decreases of blood glucose levels were recorded in all patients. Conclusion: The findings from this initial study show that expanded autologous ADSCs may be a promising treatment for T2D.

scholarly journals Steeping of Ginger (Zingiber officinale Rosce) Lowers Blood Glucose in Rat Model Type-2 Diabetes (NIDDM) as a Learning Resource Biology

2017 ◽  
Vol 2 (3) ◽  
pp. 258
Author(s):  
Andri Rudi Yanto ◽  
Nurul Mahmudati ◽  
Rr. Eko Susetyarini
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Rat Model ◽  
Zingiber Officinale ◽  
Experiment Design ◽  
Learning Resource ◽  
Model Type ◽  
True Experiment

Hiperglikemik merupakan salah satu gejala DM  yang ditandai dengan meningkatnya konsentrasi gula darah dan pengeluaran glukosa yang disertai dengan gangguan metabolisme karbohidrat, penyakit ini masih banyak di Indonesia. Obat antidiabetes kebanyakan dapat memberikan efek samping yang tidak diinginkan, maka banyak para ahli yang meramu pengobatan tradisional untuk DM yang memberikan efek aman. Penelitian ini bertujuan untuk mengungkap potensi keanekaragaman hayati rimpang jahe sebagai obat antidiabetes yang dalam bentuk seduhan  pada tikus yang diinduksi STZ. Jenis penelitian adalah True Experiment Design. Tikus dibagi menjadi 4 kelompok, yaitu kelompok normal, kelompok positif (STZ), kelompok STZ + seduhan jahe 1g/kgBB, dan kelompok STZ + seduhan jahe 3g/kgBB. Hasil penelitian menunjukkan ada pengaruh seduhan jahe sebagai obat antidiabetes pada tikus induksi STZ. Rerata kadar glukosa darah tertinggi pada kelompok positif (STZ) dan kadar glukosa darah terendah pada kelompok STZ + seduhan jahe 1g/kgBB. Penelitian ini dimanfaatkan sebagai sumber belajar berupa poster ilmiah sebagai bahan acuan untuk guru dalam pembelajaran biologi materi upaya keanekaragaman hayati dan pemanfaatannya.

Early Improvement of Glucose Tolerance after Ileal Transposition in a Non-obese Type 2 Diabetes Rat Model

2005 ◽  
Vol 15 (9) ◽  
pp. 1258-1264 ◽  
Author(s):  
Alberto Patriti ◽  
Enrico Facchiano ◽  
Claudia Annetti ◽  
Maria Cristina Aisa ◽  
Francesco Galli ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Rat Model ◽  
Ileal Transposition ◽  
Early Improvement
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