scholarly journals Correlation of Polymorphisms of Natural Resistance-Associated Macrophage Protein 1 (NRAMP1) Gene and Smoking with the Risk of Rheumatoid Arthritis in Chinese Han People

2019 ◽  
Vol 25 ◽  
pp. 5321-5326
Author(s):  
Qinghua Zou ◽  
Yi Zhao ◽  
Yong Wang ◽  
Yongfei Fang ◽  
Yi Liu
Keyword(s):  
Rheumatoid Arthritis ◽  
Natural Resistance ◽  
Chinese Han ◽  
Nramp1 Gene ◽  
Macrophage Protein ◽  
Chinese Han People

Mapping of the natural resistance-associated macrophage protein 1 (NRAMP1) gene to pig chromosome 15

1998 ◽  
Vol 29 (2) ◽  
pp. 138-140 ◽  
Author(s):  
H. S. Sun ◽  
L. Wang ◽  
M. F. Rothschild ◽  
C. K. Tuggle
Keyword(s):  
Natural Resistance ◽  
Chromosome 15 ◽  
Nramp1 Gene ◽  
Macrophage Protein

scholarly journals 3’UTR Polymorphism of NRAMP1 Gene and Susceptibility to Lung Tuberculosis among Patients and Nurses in Surabaya, Indonesia

2010 ◽  
Vol 1 (1) ◽  
pp. 17
Author(s):  
Rahayu Anggraini
Keyword(s):  
Potential Role ◽  
Natural Resistance ◽  
Restriction Enzyme Digestion ◽  
Tuberculosis Patients ◽  
Lung Tuberculosis ◽  
Study Population ◽  
Nramp1 Gene ◽  
Single Base Pair ◽  
Polymerase Chain ◽  
Macrophage Protein

The objectives of this study was to evaluate a potential role for natural-resistance-associated macrophage protein 1 (NRAMP1) gene in the human homologue using four single base pair polymorphisms (D543N, 3’UTR, INT4, 274C/T) for susceptibility to tuberculosis infection in Surabaya, Indonesia. The study population were 69 lung tuberculosis patients and 43 healthy nurses were genotyped with the polymerase chain reaction (PCR) and the product amplified from their genomic DNA were subjected to restriction enzyme digestion (RFLP) and were analysed using agarose gel electrophoresis. Results of this study showed only the homozygous TGTG deletion allele at the 3’untranslated region (3’UTR) of the NRAMP1 gene i.e. the TGTGdel/del genotype was more frequently found in lung tuberculosis patients (20/69=29%) compared to that found in nurses (2/43=4.7%). The Odds ratios (ORs) were 8.37 (95% confidence interval [CI], 1.85 to 37.94; p=0.002). This finding shows that polymorphism 3’UTR of NRAMP1 gene increased the risk of lung tuberculosis in Surabaya, Indonesia.

Polymorphism of Nramp1 Gene and Its Association with Diarrhea in Pigs

2020 ◽  
Author(s):  
Lang Chen ◽  
Shuai Peng ◽  
Bao-Qiang Fu ◽  
Qian Du ◽  
Li Zhang ◽  
...  
Keyword(s):  
Disease Resistance ◽  
Resistance Breeding ◽  
Natural Resistance ◽  
Large White ◽  
Chi Square ◽  
Exon 2 ◽  
Pig Breeds ◽  
Chi Square Test ◽  
Nramp1 Gene ◽  
Macrophage Protein

Background: Natural resistance associated macrophage protein 1 (Nramp1) is a relatively conservative gene that plays a crucial role in swine immune response and disease resistance. Methods: We identified the polymorphisms and gene variations in the exon 2 of Nramp1 using polymerase chain reaction–restriction fragment length polymorphism and investigated the correlation between the polymorphisms and piglet diarrhea in four pig breeds (Bamei, Duroc, Landrace, and Large White pigs). Result: The results showed that two alleles (A and B) were identified in all the pig breeds, three genotypes (AA, BB, and AB) were detected in Bamei and Large White breeds, and two genotypes (AA and AB) were detected in Landrace and Duroc breeds. Allele A and genotype AB were dominant in Bamei, Large White, and Landrace breeds, whereas genotype AA was dominant in Duroc pigs. A moderate polymorphism was observed in Landrace and Large White pigs, and polymorphism was abundant in Bamei pigs and low in Duroc pigs. The Chi-square test for Hardy–Weinberg equilibrium disclosed that the exon 2 of Nramp1 in the four breeds of pigs did not deviate from the Hardy–Weinberg balance (P less than 0.05). The results of association analysis showed a significant correlation between breed and piglet diarrhea (P less than 0.05), and the diarrhea score of Bamei pigs was much lower than those of the other breeds. The study could supply theoretical references for further functional research on Nramp1 gene and for screening genes related to disease-resistance breeding.

Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis

2006 ◽  
Vol 102 (1) ◽  
pp. 91-97 ◽  
Author(s):  
J YEN ◽  
C LIN ◽  
W TSAI ◽  
T OU ◽  
C WU ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Polymorphisms ◽  
Natural Resistance ◽  
Macrophage Protein

scholarly journals Bovine natural resistance associated macrophage protein 1 (Nramp1) gene.

1996 ◽  
Vol 6 (10) ◽  
pp. 956-964 ◽  
Author(s):  
J Feng ◽  
Y Li ◽  
M Hashad ◽  
E Schurr ◽  
P Gros ◽  
...  
Keyword(s):  
Natural Resistance ◽  
Nramp1 Gene ◽  
Macrophage Protein

Genomic organization of the sheep natural resistance associated macrophage protein (NRAMP1) gene

1997 ◽  
Vol 56 ◽  
pp. 121
Author(s):  
V. Bussmann ◽  
I. Lantier ◽  
F. Pitel ◽  
S. Patri ◽  
F. Nau ◽  
...  
Keyword(s):  
Genomic Organization ◽  
Natural Resistance ◽  
Nramp1 Gene ◽  
Macrophage Protein
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