scholarly journals The Role of Disturbed Small-World Networks in Patients with White Matter Lesions and Cognitive Impairment Revealed by Resting State Function Magnetic Resonance Images (rs-fMRI)

2019 ◽  
Vol 25 ◽  
pp. 341-356 ◽  
Author(s):  
Jinfang Wang ◽  
Yu Chen ◽  
Huazheng Liang ◽  
Garry Niedermayer ◽  
Hongyan Chen ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Magnetic Resonance ◽  
Resting State ◽  
White Matter Lesions ◽  
Small World ◽  
Magnetic Resonance Images ◽  
State Function ◽  
Small World Networks

Role of White Matter Lesions in Cognitive Impairment of Vascular Origin

1999 ◽  
Vol 13 (Supplement) ◽  
pp. S49-54 ◽  
Author(s):  
Leonardo Pantoni ◽  
Didier Leys ◽  
Franz Fazekas ◽  
Will T. Longstreth ◽  
Domenico Inzitari ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
Vascular Origin

scholarly journals Incidental White Matter Lesions Identified on Magnetic Resonance Images of Normal Japanese Individuals

1994 ◽  
Vol 34 (5) ◽  
pp. 286-290 ◽  
Author(s):  
Hirofumi OYAMA ◽  
Yoshihisa KIDA ◽  
Takayuki TANAKA ◽  
Takanori IWAKOSHI ◽  
Masahiro NIWA ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Lesions ◽  
Magnetic Resonance Images ◽  
Normal Japanese

scholarly journals Multiple sclerosis: High prevalence of the ‘central vein’ sign in white matter lesions on susceptibility-weighted images

2018 ◽  
Vol 31 (4) ◽  
pp. 356-361 ◽  
Author(s):  
Gianvincenzo Sparacia ◽  
Francesco Agnello ◽  
Angelo Gambino ◽  
Martina Sciortino ◽  
Massimo Midiri
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetic Resonance ◽  
Small Vessel Disease ◽  
White Matter Lesions ◽  
Magnetic Resonance Images ◽  
Inversion Recovery ◽  
Central Vein ◽  
Fluid Attenuated Inversion Recovery ◽  
The Difference

Purpose The aim of this study was to determine the occurrence and distribution of the ‘central vein’ sign in white matter lesions on susceptibility-weighted magnetic resonance images in patients with multiple sclerosis (MS) and cerebral small vessel disease (CSVD). Materials and methods T2-weighted and fluid-attenuated inversion recovery magnetic resonance images of 19 MS patients and 19 patients affected by CSVD were analysed for the presence and localisation of focal hyperintense white matter lesions. Lesions were subdivided into periventricular or non-periventricular (juxtacortical, subcortical, deep white matter and cerebellar) distributed. The number and localisation of lesions presenting with the central vein sign were recorded and compared between MS and CSVD lesions. Results A total of 313 MS patients and 75 CSVD lesions were identified on T2-weighted and fluid-attenuated inversion recovery magnetic resonance images. The central vein sign was found in 128 MS lesions (40.9%), and the majority of them (71/128, 55.5%) had a periventricular distribution. The central vein sign was found in 22 out of 75 (29.3%) CSVD lesions, and periventricular distribution was seen in six out of 22 (27.2%) CSVD lesions. The difference in the proportion of white matter hyperintense lesions that presented with the central vein sign on susceptibility-weighted images in patients with MS and CSVD was statistically different, and a significantly higher number of MS patients presented with lesions with the central vein sign compared to CSVD patients. Conclusion The presence of the central vein sign on susceptibility-weighted images for MS lesions improves the understanding of the periventricular distribution of MS lesions and could contribute as adjunctive diagnostic criteria for MS disease.

scholarly journals CHARACTERISTICS OF WHITE MATTER HYPOINTENSITY IN NORMAL COGNITIVE VIETNAMESE ADULTS USING MRI

2021 ◽  
Vol 506 (1-2) ◽  
Author(s):  
Tong Quoc Dong ◽  
Vu Khac Quy ◽  
Le Gia Vinh ◽  
Tran Hai Anh ◽  
Nguyen Le Chien
Keyword(s):  
Growth Rate ◽  
Cognitive Impairment ◽  
White Matter ◽  
Magnetic Resonance ◽  
Middle Age ◽  
Magnetic Resonance Images ◽  
Regression Analyses ◽  
Volume Characteristics ◽  
Parkinson Diseases ◽  
Cerebral Degeneration

Objectives: access the white-matter hypointensity (WMHypo) volume characteristics in relationships with age. Methods: Analysing for volumes of cerebral WMHypo volumes from cranial magnetic resonance images taken from 455 normal cognitive Vietnamese subjects (males 47,03%), and ranging in age from 17 to 87 years. Results: The volumes of WMHypo were increasing with age in both male (p< 0,001) and female (p < 0,001). And regression analyses indicated that WMHypo volume increasing in cubic manners that relatively stable with age under 40-50 y.o then sharply increase from 60s. Conclusion: White matter hypointensity had appeared since youth and boosted from middle age, since any cognitive impairment could be detected as in elders, and and its growth rate coexists with atrophy in the cerebral degeneration process such as Alzheimer and Parkinson diseases.

scholarly journals Altered Homotopic Functional Connectivity Within White Matter in the Early Stages of Alzheimer’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Pan Wang ◽  
Zedong Wang ◽  
Jianlin Wang ◽  
Yuan Jiang ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
White Matter ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Parietal Lobe ◽  
Neurodegenerative Disorder ◽  
Magnetic Resonance Images ◽  
Support Vector

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with memory loss and cognitive impairment. The white matter (WM) BOLD signal has recently been shown to provide an important role in understanding the intrinsic cerebral activity. Although the altered homotopic functional connectivity within gray matter (GM-HFC) has been examined in AD, the abnormal HFC to WM remains unknown. The present study sought to identify changes in the WM-HFC and anatomic characteristics by combining functional magnetic resonance imaging with diffusion tensor imaging (DTI). Resting-state and DTI magnetic resonance images were collected from the OASIS-3 dataset and consisted of 53 mild cognitive impairment (MCI) patients, 90 very MCI (VMCI), and 100 normal cognitive (NC) subjects. Voxel-mirrored HFC was adopted to examine whether WM-HFC was disrupted in VMCI and MCI participants. Moreover, the DTI technique was used to investigate whether specific alterations of WM-HFC were associated with anatomic characteristics. Support vector machine analyses were used to identify the MCI and VMCI participants using the abnormal WM-HFC as the features. Compared with NC, MCI, and VMCI participants showed significantly decreased GM-HFC in the middle occipital gyrus and inferior parietal gyrus and decreased WM-HFC in the bilateral middle occipital and parietal lobe-WM. In addition, specific WM-functional network alteration for the bilateral sub-lobar-WM was found in MCI subjects. MCI subjects showed abnormal anatomic characteristics for bilateral sub-lobar and parietal lobe-WM. Results of GM-HFC mainly showed common neuroimaging features for VMCI and MCI subjects, whereas analysis of WM-HFC showed specific clinical neuromarkers and effectively compensated for the lack of GM-HFC to distinguish NC, VMCI, and MCI subjects.

Magnetic Resonance Imaging White Matter Lesions and Cognitive Impairment in Hypertensive Individuals

1991 ◽  
Vol 48 (4) ◽  
pp. 417-420 ◽  
Author(s):  
R. Schmidt ◽  
F. Fazekas ◽  
H. Offenbacher ◽  
H. Lytwyn ◽  
B. Blematl ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Lesions ◽  
Resonance Imaging
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