scholarly journals High Expression of CCDC34 Is Associated with Poor Survival in Cervical Cancer Patients

2018 ◽  
Vol 24 ◽  
pp. 8383-8390
Author(s):  
Lian-Bin Liu ◽  
Jing Huang ◽  
Jin-Ping Zhong ◽  
Gui-Lin Ye ◽  
Ling Xue ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
High Expression ◽  
Poor Survival

High expression of 90K (Mac-2 BP) is associated with poor survival in node-negative breast cancer patients not receiving adjuvant systemic therapies

2009 ◽  
Vol 124 (2) ◽  
pp. 333-338 ◽  
Author(s):  
Nicola Tinari ◽  
Rossano Lattanzio ◽  
Patrizia Querzoli ◽  
Clara Natoli ◽  
Antonino Grassadonia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
High Expression ◽  
Breast Cancer Patients ◽  
Poor Survival ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Systemic Therapies

Association of high expression of Hsp90-beta and GRP 94 with poor survival in resected non-small cell lung cancer patients.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e22183-e22183 ◽  
Author(s):  
Seok-Hyun Kim ◽  
Gyeong-won Lee ◽  
Jong-Sil Lee ◽  
Yu Ji Cho ◽  
Yi Yeong Jeong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
High Expression ◽  
Small Cell Lung ◽  
Poor Survival ◽  
Lung Cancer Patients

High expression of Hsp90-beta and GRP 94 association with poor survival in resected non-small cell lung cancer patients.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e13522-e13522
Author(s):  
Shang-Hung Chen ◽  
Ching-Chuan Kuo ◽  
Chien-Feng Li ◽  
Tsui-Chun Tsou ◽  
Huai-Chih Chiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
High Expression ◽  
Small Cell Lung ◽  
Poor Survival ◽  
Lung Cancer Patients

scholarly journals Elevated Expression of Programmed Death-1 and Programmed Death Ligand-1 Negatively Regulates Immune Response against Cervical Cancer Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Zhifang Chen ◽  
Nannan Pang ◽  
Rong Du ◽  
Yuejie Zhu ◽  
Lingling Fan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Immune Response ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
High Expression ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Cervical Cancer Cells ◽  
Programmed Death 1

The present study is to measure the expression of programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1), as well as its clinical significance in cervical cancer patients. Our results showed that different T cell subsets in patients with cervical cancer had high expression of PD-1, and DCs had high expression of PD-L1. High expression of PD-1 on Treg cells in cervical cancer patients facilitated the production of TGF-βand IL-10 but inhibited the production of IFN-γ. Cervical cancer elevated the expression of PD-1 and PD-L1 in mRNA level. PD-1 expression in peripheral blood of cervical cancer patients was related with tumor differentiation, lymph node metastasis, and invasiveness. PD-1/PD-L1 pathway inhibited lymphocyte proliferation but enhanced the secretion of IL-10 and TGF-βin vitro. In summary, our findings demonstrate that elevated levels of PD-1/PD-L1, TGF-β, and IL-10 in peripheral blood of cervical cancer patients may negatively regulate immune response against cervical cancer cells and contribute to the progression of cervical cancer. Therefore, PD-1/PD-L1 pathway may become an immunotherapy target in the future.

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