scholarly journals High-Mobility Group Box 1 (HMGB1) and Autophagy in Acute Lung Injury (ALI): A Review

2019 ◽  
Vol 25 ◽  
pp. 1828-1837 ◽  
Author(s):  
Lihua Qu ◽  
Chao Chen ◽  
YangYe Chen ◽  
Yi Li ◽  
Fang Tang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
High Mobility ◽  
High Mobility Group

The Effect of Experimental Diabetes on High Mobility Group Box 1 Protein Expression in Endotoxin-Induced Acute Lung Injury

2011 ◽  
Vol 168 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Satoshi Hagiwara ◽  
Hideo Iwasaka ◽  
Chihiro Shingu ◽  
Shigekiyo Matumoto ◽  
Akira Hasegawa ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Protein Expression ◽  
Experimental Diabetes ◽  
High Mobility ◽  
High Mobility Group

scholarly journals Downregulation of high mobility group box 1 attenuates the severity of acute lung injury in endotoxemic mice

2015 ◽  
Vol 11 (6) ◽  
pp. 4513-4517 ◽  
Author(s):  
XIAOJUAN ZHANG ◽  
ZHENGGANG LUAN ◽  
YINGJIAN LIANG ◽  
YINA LIU ◽  
XIAOCHUN MA
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
High Mobility ◽  
High Mobility Group

High-mobility group box 1 protein participates in acute lung injury by activating protein kinase R and inducing M1 polarization

Life Sciences ◽  
2020 ◽  
Vol 246 ◽  
pp. 117415 ◽  
Author(s):  
Ruiting Li ◽  
You Shang ◽  
Yuan Yu ◽  
Ting Zhou ◽  
Wei Xiong ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Protein Kinase ◽  
Lung Injury ◽  
High Mobility ◽  
High Mobility Group ◽  
Protein Kinase R ◽  
M1 Polarization

Delivery of the high-mobility group box 1 box A peptide using heparin in the acute lung injury animal models

2016 ◽  
Vol 234 ◽  
pp. 33-40 ◽  
Author(s):  
Ji Hyun Song ◽  
Ji Yeon Kim ◽  
Chunxian Piao ◽  
Seonyeong Lee ◽  
Bora Kim ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
High Mobility ◽  
High Mobility Group

scholarly journals Glutamine attenuates acute lung injury by inhibition of high mobility group box protein-1 expression during sepsis

2009 ◽  
Vol 103 (6) ◽  
pp. 890-898 ◽  
Author(s):  
Woon Yong Kwon ◽  
Gil Joon Suh ◽  
Kyung Su Kim ◽  
You Hwan Jo ◽  
Jae Hyuk Lee ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Heat Shock ◽  
Dna Binding ◽  
Lung Injury ◽  
High Mobility ◽  
Binding Activity ◽  
Negative Regulator ◽  
High Mobility Group ◽  
Hsp70 Expression ◽  
Dna Binding Activity

Heat shock protein 70 (HSP70) is reported as the main factor responsible for the beneficial effects of glutamine (GLN) and as a negative regulator of high mobility group box protein-1 (HMGB-1) expression. Our aim was to determine whether GLN attenuates acute lung injury (ALI) by the inhibition of HMGB-1 expression during sepsis. Male Sprague–Dawley rats were subjected to caecal ligation and puncture (CLP) to induce sepsis. GLN or saline was administered through tail vein 1 h after CLP. Then, quercetin (Q), an inhibitor of HSP70, was utilised to assess the role of the enhanced HSP70. We observed the survival of the subjects. At 24 h post-CLP, we measured lung HSP70, phosphorylated heat shock factor-1 (HSF-1-p) and HMGB-1 expressions, NF-κB DNA-binding activity and ALI occurrence. We also measured serum HSP70, IL-6 and HMGB-1 concentrations. GLN improved survival during sepsis. In GLN-treated rats, lung HSP70 and HSF-1-p expressions were enhanced, lung HMGB-1 expression and NF-κB DNA-binding activity were suppressed, and ALI was attenuated. Furthermore, in GLN-administered rats, serum HSP70 concentration was higher, and serum IL-6 and HMGB-1 concentrations were lower than those in non-treated rats. Q inhibited the enhancement of HSP70 and HSF-1-p expressions and abrogated the GLN-mediated benefits. In conclusion, GLN attenuated ALI and improved survival by the inhibition of HMGB-1 expression during sepsis in rats. These benefits were associated with the enhancement of HSP70 expression by GLN.

scholarly journals Toll-Like Receptor 4 Mediates Acute Lung Injury Induced by High Mobility Group Box-1

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64375 ◽  
Author(s):  
Yuxiao Deng ◽  
Zhongwei Yang ◽  
Yuan Gao ◽  
Huan Xu ◽  
Beijie Zheng ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
High Mobility ◽  
High Mobility Group ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1 - induced inflammation

2021 ◽  
Vol 27 (44) ◽  
pp. 7669-7686
Author(s):  
Chang-Ju Zhu ◽  
Wan-Guang Yang ◽  
De-Jian Li ◽  
Yao-Dong Song ◽  
San-Yang Chen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Severe Acute Pancreatitis ◽  
High Mobility ◽  
High Mobility Group

Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model*

2008 ◽  
Vol 36 (8) ◽  
pp. 2407-2413 ◽  
Author(s):  
Satoshi Hagiwara ◽  
Hideo Iwasaka ◽  
Akira Hasegawa ◽  
Hironori Koga ◽  
Takayuki Noguchi
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Insulin Therapy ◽  
Rat Model ◽  
High Mobility ◽  
High Mobility Group
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