scholarly journals Role of Natural Killer T (NKT) Cells in Type II Diabetes-Induced Vascular Injuries

2018 ◽  
Vol 24 ◽  
pp. 8322-8332 ◽  
Author(s):  
Xiaohong Lv ◽  
Yun Gao ◽  
Tantan Dong ◽  
Libo Yang
Keyword(s):  
Natural Killer ◽  
Type Ii Diabetes ◽  
Nkt Cells ◽  
Vascular Injuries ◽  
Type Ii ◽  
Natural Killer T

Participatory role of natural killer and natural killer T cells in atherosclerosis: lessons learned from in vivo mouse studiesThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.

2006 ◽  
Vol 84 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Stewart C. Whitman ◽  
Tanya A. Ramsamy
Keyword(s):  
Natural Killer ◽  
Complex Disease ◽  
Immune Cell ◽  
Disease Process ◽  
Density Lipoprotein ◽  
Nkt Cells ◽  
Lessons Learned ◽  
Natural Killer T

Atherosclerosis is a multifactor, highly complex disease with numerous aetiologies that work synergistically to promote lesion development. One of the emerging components that drive the development of both early- and late-stage atherosclerotic lesions is the participation of both the innate and acquired immune systems. In both humans and animal models of atherosclerosis, the most prominent cells that infiltrate evolving lesions are macrophages and T lymphocytes. The functional loss of either of these cell types reduces the extent of atherosclerosis in mice that were rendered susceptible to the disease by deficiency of either apolipoprotein E or the LDL (low density lipoprotein) receptor. In addition to these major immune cell participants, a number of less prominent leukocyte populations that can modulate the atherogenic process are also involved. This review will focus on the participatory role of two “less prominent” immune components, namely natural killer (NK) cells and natural killer T (NKT) cells. Although this review will highlight the fact that both NK and NKT cells are not sufficient for causing the disease, the roles played by both these cells types are becoming increasingly important in understanding the complexity of this disease process.

scholarly journals Natural Killer T Cells in Various Mouse Models of Hepatitis

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Jun Guan ◽  
Gang Wang ◽  
Qin Yang ◽  
Chao Chen ◽  
Jingwen Deng ◽  
...  
Keyword(s):  
Natural Killer ◽  
Mouse Models ◽  
Fas Ligand ◽  
Basic Research ◽  
Neutrophil Infiltration ◽  
Nkt Cells ◽  
Liver Injuries ◽  
Integral Role ◽  
Natural Killer T

Natural killer T (NKT) cells are a key component of innate immunity. Importantly, a growing body of evidence indicates that NKT cells play an integral role in various acute and chronic liver injuries. NKT cells participate in the progression of an injury through the secretion of cytokines, which promote neutrophil infiltration and enhance Fas ligand (FasL) and granzyme-mediated NKT cytotoxic activity. Therefore, examining the role of NKT cells in hepatic disease is critical for a comprehensive understanding of disease pathogenesis and may provide insight into novel approaches for treatment. For more than a century, mouse models that imitate the physiopathological conditions of human disease have served as a critical tool in biological and medical basic research, including studies of liver disease. Here, we review the role of NKT cells in various mouse models of hepatitis.

scholarly journals Invariant Natural Killer T-Cells and Total CD1d Restricted Cells Differentially Influence Lipid Metabolism and Atherosclerosis in Low Density Receptor Deficient Mice

2019 ◽  
Vol 20 (18) ◽  
pp. 4566
Author(s):  
Paul A. VanderLaan ◽  
Catherine A. Reardon ◽  
Veneracion G. Cabana ◽  
Chyung-Ru Wang ◽  
Godfrey S. Getz
Keyword(s):  
Lipid Metabolism ◽  
Natural Killer ◽  
Plasma Lipids ◽  
Plasma Cholesterol ◽  
Atherosclerotic Lesion ◽  
Nkt Cells ◽  
Type I ◽  
Type Ii ◽  
Inkt Cells ◽  
Natural Killer T

Natural killer T (NKT) cells are a distinct subset of lymphocytes that bridge the innate and adaptive immune response and can be divided into type I invariant NKT cells (iNKT) and type II NKT cells. The objective of this study is to examine the effects of NKT cell on lipid metabolism and the initiation and progression of atherosclerosis in LDL receptor deficient (LDLR−/−) mice. Mice were fed an atherogenic diet for 4 or 8 weeks and plasma lipids, lipoproteins, and atherosclerosis were measured. The selective absence of iNKT cells in Jα18−/−LDLR−/− mice led to an increase in plasma cholesterol levels in female mice. Transgenic Vα14tg/LDLR−/− mice with elevated numbers of iNKT cells had increased late atherosclerosis of the innominate artery, though absence of either iNKT cells or all NKT cells and other CD1d expressing cells had varying effects on atherosclerotic lesion burden in the ascending aortic arch and aortic root. These studies not only highlight the potential modulatory role played by NKT cells in atherosclerosis and lipid metabolism, but also raise the possibility that divergent roles may be played by iNKT and CD1d restricted cells such as type II NKT cells or other CD1d expressing cells.

scholarly journals Regulation of the Induction and Function of Cytotoxic T Lymphocytes by Natural Killer T Cell

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Hiroyasu Ito ◽  
Mitsuru Seishima
Keyword(s):  
T Lymphocytes ◽  
Natural Killer ◽  
Cytotoxic T Lymphocytes ◽  
Treatment Strategies ◽  
Nkt Cells ◽  
Host Immune System ◽  
Type I ◽  
Type Ii ◽  
And Function ◽  
Natural Killer T

Cytotoxic T lymphocytes (CTLs) play a crucial role in the infections and the antitumor immunity. Induction and activation of antigen-specific CTLs is an important strategy in immunotherapy for various diseases, and several researchers have focused on the modulation of CTL induction and function. Natural killer T (NKT) cells are an important focus area of researchers studying immunomodulatory responses to tumors and infectious diseases. CD1d-restricted NKT cells consist of type I NKT cells and type II NKT cells. -galactosylceramide (-GalCer)-activated type I NKT cells secrete both Th1 (e.g., IFN-) and Th2 cytokines, affect the expression of costimulatory molecules in immune cells, and regulate the host immune system. Type II NKT cells, however, are stimulated by sulfatide, a self-glycolipid derived from myelin, and play an immunosuppressive role in animal model of autoimmune diseases. CTL generation, activation, and suppression are strongly affected by activated type I and type II NKT cells. Thus, the regulation of these NKT cells leads to the modification of CTL function. CTLs contribute to antimicrobial responses, antitumor immune and autoimmune responses. Understanding the role of NKT cells in the regulation of CTL generation, activation, and suppression enable the development of novel treatment strategies for these diseases.

scholarly journals Identification and Simian Immunodeficiency Virus Infection of CD1d-Restricted Macaque Natural Killer T Cells

2003 ◽  
Vol 77 (14) ◽  
pp. 8153-8158 ◽  
Author(s):  
Alison Motsinger ◽  
Agnes Azimzadeh ◽  
Aleksandar K. Stanic ◽  
R. Paul Johnson ◽  
Luc Van Kaer ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer ◽  
Simian Immunodeficiency Virus ◽  
Cell Receptor ◽  
Nkt Cells ◽  
Immunodeficiency Virus ◽  
Siv Infection ◽  
Hiv 1 ◽  
Natural Killer T

ABSTRACT Natural killer T (NKT) cells express a highly conserved T-cell receptor (TCR) and recognize glycolipids in the context of CD1d molecules. We recently demonstrated that CD4+ NKT cells are highly susceptible to human immunodeficiency virus type 1 (HIV-1) infection and are selectively depleted in HIV-infected individuals. Here, we identified macaque NKT cells using CD1d tetramers and human Vα24 antibodies. Similar to human NKT cells, α-galactosylceramide (α-GalCer)-pulsed dendritic cells activate and expand macaque NKT cells. Upon restimulation with α-GalCer-pulsed CD1d+ cells, macaque NKT cells secreted high levels of cytokines, a characteristic of these T cells. Remarkably, the majority of resting and activated macaque NKT cells expressed CD8, and a smaller portion expressed CD4. Macaque NKT cells also expressed the HIV-1/simian immunodeficiency virus (SIV) coreceptor CCR5, and the CD4+ subset was susceptible to SIV infection. Identification of macaque NKT cells has major implications for delineating the role of these cells in nonhuman primate disease models of HIV as well as other pathological conditions, such as allograft rejection and autoimmunity.

scholarly journals Type I natural killer T cells suppress tumors caused by p53 loss in mice

Blood ◽  
2009 ◽  
Vol 113 (25) ◽  
pp. 6382-6385 ◽  
Author(s):  
Jeremy B. Swann ◽  
Adam P. Uldrich ◽  
Serani van Dommelen ◽  
Janelle Sharkey ◽  
William K. Murray ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer ◽  
Immune Surveillance ◽  
Tumor Development ◽  
Natural Killer T Cells ◽  
Nkt Cells ◽  
Type I ◽  
Killer T Cells ◽  
Natural Killer T

Abstract CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural killer T (NKT) cells in tumor immune surveillance has been weak and data from several tumor models has suggested that some (type II) CD1d-restricted T cells may also suppress some types of antitumor immune response. To substantiate an important role for CD1d-restricted T cells in host response to cancer, we have evaluated tumor development in p53+/− mice lacking either type I NKT cells (TCR Jα18−/−) or all CD1d-restricted T cells (CD1d−/−). Our findings support a key role for type I NKT cells in suppressing the onset of sarcomas and hematopoietic cancers caused by p53 loss but do not suggest that other CD1d-restricted T cells are critical in regulating the same tumor development.

The Role of Natural Killer T (NKT) Cells in the Pathogenesis of Type 1 Diabetes

2011 ◽  
Vol 7 (4) ◽  
pp. 278-283 ◽  
Author(s):  
Rita A. Gomez-Diaz ◽  
Mayra V. Aguilar ◽  
Elisa N. Meguro ◽  
Rocio H. Marquez ◽  
Eulalia G. Magana ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Natural Killer ◽  
Nkt Cells ◽  
Natural Killer T

scholarly journals Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Samanta Melgar-Rodríguez ◽  
Emilio A. Cafferata ◽  
Nicolás I. Díaz ◽  
Miguel A. Peña ◽  
Luis González-Osuna ◽  
...  
Keyword(s):  
Immune Responses ◽  
Natural Killer ◽  
Inflammatory Diseases ◽  
Nkt Cells ◽  
Regulatory Role ◽  
Th17 Lymphocytes ◽  
Antigen Presenting ◽  
Potential Regulatory Role ◽  
Natural Killer T

Natural killer T (NKT) cells constitute a unique subset of T lymphocytes characterized by specifically interacting with antigenic glycolipids conjugated to the CD1d receptor on antigen-presenting cells. Functionally, NKT cells are capable of performing either effector or suppressor immune responses, depending on their production of proinflammatory or anti-inflammatory cytokines, respectively. Effector NKT cells are subdivided into three subsets, termed NKT1, NKT2, and NKT17, based on the cytokines they produce and their similarity to the cytokine profile produced by Th1, Th2, and Th17 lymphocytes, respectively. Recently, a new subgroup of NKT cells termed NKT10 has been described, which cooperates and interacts with other immune cells to promote immunoregulatory responses. Although the tissue-specific functions of NKT cells have not been fully elucidated, their activity has been associated with the pathogenesis of different inflammatory diseases with immunopathogenic similarities to periodontitis, including osteolytic pathologies such as rheumatoid arthritis and osteoporosis. In the present review, we revise and discuss the pathogenic characteristics of NKT cells in these diseases and their role in the pathogenesis of periodontitis; particularly, we analyze the potential regulatory role of the IL-10-producing NKT10 cells.

Sign in / Sign up

Export Citation Format

Share Document