scholarly journals Linkage Analysis of the Chromosome 5q31-33 Region Identifies JAKMIP2 as a Risk Factor for Graves’ Disease in the Chinese Han Population

2019 ◽  
Vol 25 ◽  
pp. 1439-1451
Author(s):  
Jia Li ◽  
Weiping Teng ◽  
Yang Yu ◽  
Xin Hou ◽  
Zhongyan Shan
Keyword(s):  
Risk Factor ◽  
Linkage Analysis ◽  
Chinese Han Population ◽  
Graves Disease ◽  
Chinese Han ◽  
Han Population ◽  
Chromosome 5Q31

scholarly journals Polymorphisms but Not Mutations of theKCNQ1Gene Are Associated with Lone Atrial Fibrillation in the Chinese Han Population

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Hui-min Chu ◽  
Ming-jun Feng ◽  
Yi-gang Li ◽  
Yi-xin Zhang ◽  
Ji-fang Ma ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Risk Factor ◽  
Chinese Han Population ◽  
Chinese Patients ◽  
Delayed Rectifier ◽  
Allelic Association ◽  
Healthy Controls ◽  
Chinese Han ◽  
Han Population ◽  
Common Genetic Variants

Background. Recent studies suggest that mutation of the slow delayed rectifier potassium channel (IKs) contributes to familial atrial fibrillation (FAF). In the current study, we identified common genetic variants ofKCNQ1and explored the potential association betweenKCNQ1polymorphism with lone AF (LAF).Methods. Clinical data and blood samples were collected from 190 Han Chinese patients with sporadic AF and matched healthy controls. Variants of theKCNQ1gene were identified using single-strand conformational polymorphism (SSCP) analysis. A case-control association study inKCNQ1identified six known single-nucleotide polymorphisms (SNPs) during SSCP screening of the 190 LAF patients and 190 healthy controls.Results. One of the SNPs inKCNQ1was strongly associated with LAF; significant allelic association was detected rs59233444 (P=0.013,OR=1.469, 95% confidence interval (CI): 1.083–1.993). A multiple regression analysis indicated that rs59233444 is an independent risk factor for LAF. Twelve new variants were identified inKCNQ1, including one in the 5′-UTR, two in the 3′-UTR, six in introns, two synonymous substitutions, and one missense substitution. Variants c.1009C>T, c.1860C>T, and c.+2285C>T were not present in the 190 controls, and the others were identified in controls at various frequencies.Conclusions. rs59233444, a common SNP but not mutation in the coding regions of theKCNQ1gene, is a risk factor for LAF in Chinese Han population.

scholarly journals TLR1 polymorphism rs4833095 as a risk factor for IgA nephropathy in a Chinese Han population: A case-control study

Oncotarget ◽  
2016 ◽  
Vol 7 (50) ◽  
pp. 83031-83039 ◽  
Author(s):  
Jie Gao ◽  
Linting Wei ◽  
Jiali Wei ◽  
Ganglian Yao ◽  
Li Wang ◽  
...  
Keyword(s):  
Risk Factor ◽  
Iga Nephropathy ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Control Study

Foxp3 gene polymorphisms and haplotypes associate with susceptibility of Graves' disease in Chinese Han population

2015 ◽  
Vol 25 (2) ◽  
pp. 425-431 ◽  
Author(s):  
Lei Zheng ◽  
XiaoBei Wang ◽  
Lijuan Xu ◽  
Ning Wang ◽  
Pengcheng Cai ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Graves Disease ◽  
Chinese Han ◽  
Han Population ◽  
Foxp3 Gene

Polymorphisms of the T-cell immunoglobulin and mucin domain molecule-3 are not associated with autoimmune Graves' disease in a Chinese Han Population

2012 ◽  
Vol 45 (18) ◽  
pp. 1624-1628 ◽  
Author(s):  
Tao Liang ◽  
Xiao Bei Wang ◽  
Peng Cheng Cai ◽  
Zhao Ming Tang ◽  
Zhi Zhong Chen ◽  
...  
Keyword(s):  
T Cell ◽  
Chinese Han Population ◽  
Graves Disease ◽  
Chinese Han ◽  
Han Population

Linkage of Graves? disease to the human leucocyte antigen region in the Chinese-Han population in Taiwan

2007 ◽  
Vol 66 (5) ◽  
pp. 646-651 ◽  
Author(s):  
Pei-Lung Chen ◽  
Cathy Shen-Jang Fann ◽  
Chien-Ching Chang ◽  
I-Lin Wu ◽  
Wei-Yih Chiu ◽  
...  
Keyword(s):  
Human Leucocyte Antigen ◽  
Chinese Han Population ◽  
Graves Disease ◽  
Chinese Han ◽  
Han Population
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