scholarly journals EphA8 is a Prognostic Factor for Oral Tongue Squamous Cell Carcinoma

2018 ◽  
Vol 24 ◽  
pp. 7213-7222 ◽  
Author(s):  
Lijun Liu ◽  
Xiaofeng Wang ◽  
Wenzhang Ge
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue

scholarly journals Nox4 Overexpression as a Poor Prognostic Factor in Patients with Oral Tongue Squamous Cell Carcinoma Receiving Surgical Resection

2018 ◽  
Vol 7 (12) ◽  
pp. 497
Author(s):  
Yen-Hao Chen ◽  
Chih-Yen Chien ◽  
Fu-Min Fang ◽  
Tai-Lin Huang ◽  
Yan-Ye Su ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Surgical Resection ◽  
Cell Lines ◽  
Squamous Cell ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue ◽  
Poor Prognostic Factor ◽  
Low Expression

Background: Nox4 has been reported to promote tumor progression of various types of cancer through many different pathways. The current study was designed to evaluate the prognostic significance of Nox4 in patients with oral tongue squamous cell carcinoma (OTSCC) receiving surgical resection. Methods: We retrospectively analyzed the 161 patients with OTSCC treated with surgical resection, including 81 patients with high expression of Nox4 and 80 patients with low expression of Nox4. Two OTSCC cell lines, SAS and SCC4, were used to investigate the proliferation activity. Results: The univariate and multivariable analyses showed that negative nodal metastasis and low expression of Nox4 were significantly associated with superior disease-free survival (DFS) and overall survival (OS). Western blotting analysis indicated that Nox4 was highly expressed in these two OTSCC cell lines and knockdown of Nox4 was successful by transfecting with Nox4 shRNA. In addition, these cell lines were also treated with a Nox4 inhibitor (GKT-137831) and the results showed GKT-137831 could inhibit the proliferation of OTSCC tumor cells in a dose-dependent manner. Conclusion: Our study suggests that Nox4 plays an important role in disease progression of OTSCC and Nox4 overexpression is a poor prognostic factor for patients with OTSCC who received surgical resection.

scholarly journals The Effect of Interleukin‐17F on Vasculogenic Mimicry in Oral Tongue Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Rabeia Almahmoudi ◽  
Abdelhakim Salem ◽  
Elin Hadler‐Olsen ◽  
Gunbjørg Svineng ◽  
Tuula Salo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Vasculogenic Mimicry ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue ◽  
Interleukin 17F

scholarly journals Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180620 ◽  
Author(s):  
Pei-Feng Liu ◽  
Yu-Chang Hu ◽  
Bor-Hwang Kang ◽  
Yu-Kai Tseng ◽  
Pi-Chuang Wu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Caspase 3 ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue ◽  
Expression Levels

scholarly journals The mutational landscape of early‐ and typical‐onset oral tongue squamous cell carcinoma

Cancer ◽  
2020 ◽  
Author(s):  
Benjamin R. Campbell ◽  
Zhishan Chen ◽  
Daniel L. Faden ◽  
Nishant Agrawal ◽  
Ryan J. Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue ◽  
Mutational Landscape
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