scholarly journals Sinomenine Regulates Inflammatory Response and Oxidative Stress via Nuclear Factor kappa B (NF-κB) and NF-E2-Related Factor 2 (Nrf2) Signaling Pathways in Ankle Fractures in Children

2018 ◽  
Vol 24 ◽  
pp. 6649-6655 ◽  
Author(s):  
Jie Shen ◽  
Rong Yao ◽  
Mei Jing ◽  
Zhiyu Zhou
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Signaling Pathways ◽  
Nuclear Factor Kappa B ◽  
Ankle Fractures ◽  
Related Factor ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Fractures In Children ◽  
And Oxidative Stress

scholarly journals Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling

2021 ◽  
Vol 15 ◽  
Author(s):  
Yue Fu ◽  
Jianping Jia
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Molecular Mechanisms ◽  
Morphological Changes ◽  
No Production ◽  
Related Factor ◽  
Nuclear Factor ◽  
Qrt Pcr ◽  
Bv2 Cells ◽  
And Oxidative Stress

BackgroundNeuroinflammation and oxidative stress are two major pathological characteristics of Alzheimer’s disease (AD). Amyloid-β oligomers (AβO), a toxic form of Aβ, promote the neuroinflammation and oxidative stress in the development of AD. Isoliquiritigenin (ISL), a natural flavonoid isolated from the root of liquorice, has been shown to exert inhibitory effects on inflammatory response and oxidative stress.ObjectivesThe main purpose of this study is to assess the influence of ISL on inflammatory response and oxidative stress in BV2 cells stimulated with AβO, and to explore the underlying molecular mechanisms.Methods3-(4,5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H- tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) cytotoxicity assays were used to assess the toxic or protective effects of ISL. The expression levels of interleukin-1β, interleukin-6, and tumor necrosis factor-α were assessed by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assays. Morphological changes in BV2 cells were assessed by immunofluorescence method. Nitric oxide (NO) assay kit was used to determinate the NO production. Western blot, qRT-PCR and immunofluorescence were used to explore the underlying molecular mechanisms.ResultsISL treatment reduced the production of inflammatory cytokines and NO, and alleviated the morphological changes in BV2 cells induced by AβO. ISL treatment further protected N2a cells from the toxic medium of AβO-stimulated BV2 cells. ISL activated nuclear factor erythroid-2 related factor 2 (Nrf2) signaling and suppressed nuclear factor-κB (NF-κB) signaling in BV2 cells.ConclusionISL suppresses AβO-induced inflammation and oxidative stress in BV2 cells via the regulation of Nrf2/NF-κB signaling. Therefore, ISL indirectly protects neurons from the damage of toxic conditioned media.

Cocaine causes memory and learning impairments in rats: involvement of nuclear factor kappa B and oxidative stress, and prevention by topiramate

2010 ◽  
Vol 114 (3) ◽  
pp. 675-684 ◽  
Author(s):  
María Muriach ◽  
Rosa López-Pedrajas ◽  
Jorge M. Barcia ◽  
María V. Sanchez-Villarejo ◽  
Inmaculada Almansa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Memory And Learning ◽  
Learning Impairments ◽  
Nuclear Factor Kappa ◽  
And Oxidative Stress

scholarly journals Protein kinase D exerts neuroprotective functions during oxidative stress via nuclear factor kappa B-independent signaling pathways

2017 ◽  
Vol 142 (6) ◽  
pp. 948-961 ◽  
Author(s):  
Hanna Liliom ◽  
Krisztián Tárnok ◽  
Zsófia Ábrahám ◽  
Bence Rácz ◽  
Angelika Hausser ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Kinase ◽  
Signaling Pathways ◽  
Nuclear Factor Kappa B ◽  
Protein Kinase D ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa
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