scholarly journals Valsartan Alleviates Insulin Resistance in Skeletal Muscle of Chronic Renal Failure Rats

2018 ◽  
Vol 24 ◽  
pp. 2413-2419 ◽  
Author(s):  
Yang Wang ◽  
Ri-bao Wei ◽  
Yue Yang ◽  
Ting-Yu Su ◽  
Meng-Jie Huang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Renal Failure ◽  
Chronic Renal Failure

Activity of insulin receptor kinase and glycogen synthase in skeletal muscle from patients with chronic renal failure

1989 ◽  
Vol 121 (5) ◽  
pp. 744-750 ◽  
Author(s):  
Jens F. Bak ◽  
Ole Schmitz ◽  
Søren S. Sørensen ◽  
Jens Frøkjær ◽  
Torben Kjær ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Insulin Receptor ◽  
Glycogen Synthase ◽  
Insulin Receptors ◽  
Receptor Function ◽  
Uremic Patients ◽  
Glycogen Synthase Activity

Abstract. To examine subcellular mechanisms behind the pathogenesis of peripheral insulin resistance in chronic uremic patients, insulin receptor function and glycogen synthase activity were studied in biopsies of skeletal muscle obtained during renal transplant surgery in 9 non-diabetic uremic patients. The results were compared with values obtained in an age- and sex-matched group of subjects with normal renal function, undergoing surgery for urological or gynecological diseases. The recovery of solubilized, wheat germ agglutinin-purified insulin receptors from skeletal muscle was increased among the uremic patients: 49.3 ± 6.1 vs 31.4 ± 2.8 fmol/100 mg muscle in healthy controls (p < 0.03). Basal as well as insulin-stimulated kinase activities of the insulin receptors, expressed as phosphorylation of the synthetic peptide poly(Glu-Tyr(4:1)) were similar. In addition, the maximal activity of the glycogen synthase was enhanced in uremic muscle: 26.6 ± 2.8 vs 19.5 ± 1.8 nmol · (mg protein)−1 · min−1 (p < 0.05), whereas the half-maximal activation constant for glucose-6-phosphate was identical in the two groups. Likewise, the muscle glycogen concentrations were similar in the uremic patients and the normal controls. In conclusion, our data suggest that neither impaired insulin receptor function nor a reduced maximal glycogen synthase activity of skeletal muscle are involved in the pathogenesis of the insulin resistance of patients with chronic renal failure.

Brief Review Insulin Resistance in Chronic Renal Failure

1985 ◽  
Vol 11 (1-2) ◽  
pp. 113-125 ◽  
Author(s):  
M. L. Mccalebeb ◽  
J. B. Wish ◽  
D. H. Lockwood
Keyword(s):  
Insulin Resistance ◽  
Renal Failure ◽  
Chronic Renal Failure

Potassium in Whole Body, Skeletal Muscle and Erythrocytes in Chronic Renal Failure

Nephron ◽  
1983 ◽  
Vol 33 (3) ◽  
pp. 173-178 ◽  
Author(s):  
Folke Ericsson ◽  
Björn Carlmark
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Whole Body

Impaired Lactate Production by Skeletal Muscle with Anaerobic Exercise in Patients with Chronic Renal Failure

Nephron ◽  
1982 ◽  
Vol 31 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Toshiyuki Nakao ◽  
Seiji Fujiwara ◽  
Kazuo Isoda ◽  
Tadashi Miyahara
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Lactate Production ◽  
Anaerobic Exercise

scholarly journals Insulin resistance and hyperinsulinaemia in mild to moderate progressive chronic renal failure and its association with aerobic work capacity

Diabetologia ◽  
1995 ◽  
Vol 38 (5) ◽  
pp. 565-572 ◽  
Author(s):  
I. Eidemak ◽  
B. Feldt-Rasmussen ◽  
I. -L. Kanstrup ◽  
S. L. Nielsen ◽  
O. Schmitz ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Work Capacity ◽  
Aerobic Work Capacity

scholarly journals Skeletal muscle protein synthesis and degradation in patients with chronic renal failure

1994 ◽  
Vol 45 (5) ◽  
pp. 1432-1439 ◽  
Author(s):  
Giacomo Garibotto ◽  
Rodolfo Russo ◽  
Antonella Sofia ◽  
Maria Rita Sala ◽  
Cristina Robaudo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Protein Synthesis ◽  
Chronic Renal Failure ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Skeletal Muscle Protein ◽  
Skeletal Muscle Protein Synthesis ◽  
Protein Synthesis And Degradation ◽  
Synthesis And Degradation
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