scholarly journals Cervical Cancer Cell Growth, Drug Resistance, and Epithelial-Mesenchymal Transition Are Suppressed by g-Secretase Inhibitor RO4929097

2018 ◽  
Vol 24 ◽  
pp. 4046-4053 ◽  
Author(s):  
Lu Wang ◽  
Guo Dai ◽  
Jian Yang ◽  
Wanrong Wu ◽  
Wei Zhang
Keyword(s):  
Cervical Cancer ◽  
Drug Resistance ◽  
Cell Growth ◽  
Cancer Cell ◽  
Epithelial Mesenchymal Transition ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth ◽  
Mesenchymal Transition ◽  
Secretase Inhibitor

scholarly journals HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dan Lei ◽  
Wen-Ting Yang ◽  
Peng-Sheng Zheng
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Tumor Formation ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth ◽  
Bioinformatics Analyses

AbstractHomeobox B4 (HOXB4), which belongs to the homeobox (HOX) family, possesses transcription factor activity and has a crucial role in stem cell self-renewal and tumorigenesis. However, its biological function and exact mechanism in cervical cancer remain unknown. Here, we found that HOXB4 was markedly downregulated in cervical cancer. We demonstrated that HOXB4 obviously suppressed cervical cancer cell proliferation and tumorigenic potential in nude mice. Additionally, HOXB4-induced cell cycle arrest at the transition from the G0/G1 phase to the S phase. Conversely, loss of HOXB4 promoted cervical cancer cell growth both in vitro and in vivo. Bioinformatics analyses and mechanistic studies revealed that HOXB4 inhibited the activity of the Wnt/β-catenin signaling pathway by direct transcriptional repression of β-catenin. Furthermore, β-catenin re-expression rescued HOXB4-induced cervical cancer cell defects. Taken together, these findings suggested that HOXB4 directly transcriptional repressed β-catenin and subsequently inactivated the Wnt/β-catenin signaling pathway, leading to significant inhibition of cervical cancer cell growth and tumor formation.

scholarly journals Ultrasound Microbubbles-mediated Microrna-505 Regulates Cervical Cancer Cell Growth via AKT2

2020 ◽  
Author(s):  
Leilei Xu ◽  
Qin Zhang ◽  
Changhua Li ◽  
Fu Hua ◽  
Xiaoping Liu
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth ◽  
Ultrasound Microbubbles

Abstract The authors have withdrawn this preprint due to erroneous posting.

scholarly journals Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Mingo Ming Ho Yung ◽  
David Wai Chan ◽  
Vincent Wing Sun Liu ◽  
Kwok-Ming Yao ◽  
Hextan Yuen-Sheung Ngan
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Cervical Cancer Cell ◽  
Signaling Cascade ◽  
Cancer Cell Growth
Sign in / Sign up

Export Citation Format

Share Document