scholarly journals Clinical Significance of Ubiquitin Specific Protease 7 (USP7) in Predicting Prognosis of Hepatocellular Carcinoma and its Functional Mechanisms

2018 ◽  
Vol 24 ◽  
pp. 1742-1750 ◽  
Author(s):  
Xujing Wang ◽  
Qiqi Zhang ◽  
Yongkun Wang ◽  
Huiren Zhuang ◽  
Bo Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Specific Protease ◽  
Ubiquitin Specific Protease ◽  
Functional Mechanisms

scholarly journals Clinical significance of expression of ubiquitin-specific protease 9X and Survivin in pancreatic carcinoma

2014 ◽  
Vol 22 (33) ◽  
pp. 5164
Author(s):  
Ze-Qiang Ren ◽  
Peng-Bo Zhang ◽  
Wei-Chao Ding ◽  
Xiu-Zhong Zhang ◽  
Chong Zhang
Keyword(s):  
Pancreatic Carcinoma ◽  
Clinical Significance ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

scholarly journals Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wei Zhang ◽  
Jingxin Zhang ◽  
Chenzhou Xu ◽  
Shiqing Zhang ◽  
Saiyan Bian ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

scholarly journals Dual loss of USP10 and p14ARF protein expression is associated with poor prognosis in patients with small intestinal adenocarcinoma

Tumor Biology ◽  
2018 ◽  
Vol 40 (10) ◽  
pp. 101042831880867 ◽  
Author(s):  
Joon Seon Song ◽  
Joo Mi Yi ◽  
Hanbyoul Cho ◽  
Chel Hun Choi ◽  
Yoonho Park ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Prognostic Indicator ◽  
Lymphatic Invasion ◽  
Vital Role ◽  
Tissue Samples ◽  
Multivariate Survival ◽  
Specific Protease ◽  
Ubiquitin Specific Protease ◽  
Small Intestinal ◽  
Small Intestinal Adenocarcinoma

Oncogene-induced senescence occurs following oncogene activation in normal cells and is considered as a critical tumor-suppressing mechanism. Ubiquitin-specific protease 10 (USP10) has been reported to play a vital role in oncogene-induced senescence via the deubiquitination-dependent stabilization of p14ARF. However, knowledge of the clinical significance of USP10 and p14ARF expression in patients with small intestinal adenocarcinoma is limited. To study the clinical significance of USP10 and p14ARF expression, we performed immunohistochemistry for USP10 and p14ARF on 195 surgically resected small intestinal adenocarcinoma specimens. Furthermore, we performed methylation analysis on five small intestinal adenocarcinoma samples and matched adjacent normal intestinal tissue samples. UPS10 ( p = 0.023) and p14ARF ( p = 0.007) expression were significantly decreased in adenocarcinoma in comparison with normal tissue. The loss of USP10 was observed in 124/194 (63.9%) of small intestinal adenocarcinoma samples and was correlated with a higher pT stage ( p = 0.044), lymphatic invasion ( p = 0.033), and the absence of sporadic adenoma ( p = 0.024) and peritumoral dysplasia ( p = 0.019). p14ARF expression was downregulated in 75/195 (38.5%) of small intestinal adenocarcinoma samples and was associated with vascular ( p = 0.011) and lymphatic ( p = 0.013) invasions. The loss of USP10 expression was associated with the loss of p14ARF expression ( r = 0.342, p < 0.001). Multivariate survival analysis revealed that the combined loss of USP10 and p14ARF expression could be an independent prognostic factor for overall survival in small intestinal adenocarcinoma. Furthermore, the aberrant hypermethylation of the USP10 and p14ARF promoter could be a key mechanism for the downregulation of USP10 and p14ARF proteins in small intestinal adenocarcinoma. These findings suggest that the dual loss of USP10 and p14ARF could be used as a prognostic indicator of small intestinal adenocarcinoma.

scholarly journals High Expression of Ubiquitin-Specific Protease 39 and Its Roles in Prognosis in Patients with Hepatocellular Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yu Liao ◽  
Lin Li ◽  
Huabao Liu ◽  
Yi Song
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Features ◽  
Mrna Level ◽  
Diagnostic Value ◽  
Histologic Grade ◽  
High Expression ◽  
Pathologic Stage ◽  
T Stage ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

Background. Ubiquitin-specific protease 39 is mainly involved in mRNA splicing and multiple kinds of tumors. Accumulating evidence has shown that USP39 participated in the proliferation and metastasis of hepatocellular carcinoma (HCC). The present study aimed to demonstrate the association between USP39 expression and clinical features and the diagnostic value in HCC based on the Cancer Genome Atlas (TCGA). Methods. A comprehensive analysis for expression of USP39 in HCC was conducted by using multiple databases. The mRNA level of USP39, clinical features, survival rate, and diagnostic value in HCC were analyzed using data from TCGA. The Gene Set Enrichment Analysis (GSEA) was conducted to analyze signaling pathways correlated with USP39 expression in HCC. Results. The mRNA level of USP39 was significantly elevated in HCC. The expression of USP39 showed significant correlation with T stage, pathologic stage, tumor status, age, and histologic grade. Logistic analysis demonstrated that high expression of USP39 was significantly associated with older age, tumor status, advanced pathologic stage, T stage, and higher histologic grade. Univariate Cox regression analysis showed that high expression of USP39 was significantly associated with advanced T stage, pathological stage, and tumor status. Multivariate Cox analysis confirmed the result that USP39 expression was an independent prognostic factor for overall survival (OS) in HCC. Results of Kaplan–Meier curves showed that high expression of USP39 had a significant association with poor OS, disease-free survival (DSS), and progress-free interval (PFI) in HCC. ROC analysis indicated that USP39 could be regarded as a promising marker for distinguishing HCC from nontumor. Conclusion. The increased USP39 might play roles in the progression, diagnosis, and prognosis of HCC.

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