scholarly journals Effects of Genetic Polymorphisms of CYP2B6 on the Pharmacokinetics of Bupropion and Hydroxybupropion in Healthy Chinese Subjects

2018 ◽  
Vol 24 ◽  
pp. 2158-2163 ◽  
Author(s):  
Hui Ma ◽  
Wenping Zhang ◽  
Xiaoying Yang ◽  
Yuxin Zhang ◽  
Shijie Wei ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Healthy Chinese ◽  
Chinese Subjects

Influence of genetic polymorphisms on the pharmacokinetics of celecoxib and its two main metabolites in healthy Chinese subjects

2015 ◽  
Vol 79 ◽  
pp. 13-19 ◽  
Author(s):  
Ruijuan Liu ◽  
Chuting Gong ◽  
Lei Tao ◽  
Wen Yang ◽  
Xiaohong Zheng ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Healthy Chinese ◽  
Chinese Subjects

Effects of genetic polymorphisms of CYP2C19*2/*3 and MDR1 C3435T on the pharmacokinetics of lansoprazole in healthy Chinese subjects

2014 ◽  
Vol 52 (10) ◽  
pp. 850-855 ◽  
Author(s):  
Yu-Xin Zhang ◽  
·Shi-Jie Wei ◽  
·Xiao-Ying Yang ◽  
·Wen-Ping Zhang ◽  
Xin-Yu Wang ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Healthy Chinese ◽  
Chinese Subjects

Impact of 14 types of genetic polymorphisms on antihypertensive efficacy of felodipine in healthy Chinese subjects

2020 ◽  
Vol 58 (07) ◽  
pp. 375-386
Author(s):  
Zi-Qing-Yun Yuan ◽  
Hong-Wen Zhang ◽  
Zi-Dan Yu ◽  
Yuan Tian ◽  
Lu-Ning Sun ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Antihypertensive Efficacy ◽  
Healthy Chinese ◽  
Chinese Subjects

941-P: A Trial to Assess the Pharmacokinetics, Safety, and Tolerability of Semaglutide in Healthy Chinese Subjects

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 941-P
Author(s):  
AIXIN SHI ◽  
PANPAN XIE ◽  
LASSE L. NIELSEN ◽  
TRINE V. SKJOETH ◽  
XUEMEI HE ◽  
...  
Keyword(s):  
Healthy Chinese ◽  
Chinese Subjects

A Randomized Study on the Bioequivalence of Desloratadine in Healthy Chinese Subjects and the Association of Different Metabolic Phenotypes With UGT2B10 and CYP2C8 Genotypes

2020 ◽  
Vol 21 (13) ◽  
pp. 1031-1039
Author(s):  
Suping Niu ◽  
Yan Li ◽  
Wenliang Dong ◽  
Lin Xia ◽  
Tiantian Shen ◽  
...  
Keyword(s):  
Reference Product ◽  
Geometric Mean ◽  
Randomized Study ◽  
Metabolic Ratio ◽  
Taqman Assay ◽  
Serious Adverse Events ◽  
Metabolic Phenotypes ◽  
Test Product ◽  
Healthy Chinese ◽  
Chinese Subjects

Background: Desloratadine is a drug with a phenotypic polymorphism in metabolism and has been approved for use in many countries to treat allergic diseases. CYP2C8 and UGT2B10 are metabolic enzymes, which may be involved in the metabolism of desloratadine. Objective: This study aimed to demonstrate bioequivalence between the test product (desloratadine tablet) and the reference product AERIUS (5mg), both orally administered. And the role of UGT2B10 and CYP2C8 genotypes in healthy Chinese subjects with different Desloratadine metabolic phenotypes was examined. Methods: It was a randomized, open-label, and four-sequence, single-dose crossover study conducted on 56 healthy Chinese subjects. The pharmacokinetics (PK) and safety of the test and reference Desloratadine products were compared. UGT2B10 and CYP2C8 genotypes were determined by the TaqMan assay using genomic DNA. Multiple linear regression was applied to analyze the correlation between genotypes and the metabolic ratio. Results: The mean serum concentration-time curves of desloratadine and 3-OH-desloratadine were similar between the test product and the reference product. For the PK similarity comparison, the 90% CIs for the geometric mean ratios of Cmax, AUC0-t, and AUC0-∞ of desloratadine and 3-OH-desloratadine of test and reference product were completely within 80-125%. None of all 56 subjects had serious adverse events. Only 2 subjects were poor-metabolizers in 56 healthy subjects. There was no significant correlation between investigated genotypes of CYP2C8 and UGT2B10 and the metabolic ratio. Conclusion: The test desloratadine tablet was bioequivalent to the reference product. No direct relationship between CYP2C8 and UGT2B10 genotypes and desloratadine metabolic ratio was identified.

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