scholarly journals Exosomes Released by Gastric Cancer Cells Induce Transition of Pericytes Into Cancer-Associated Fibroblasts

2018 ◽  
Vol 24 ◽  
pp. 2350-2359 ◽  
Author(s):  
Xiaofei Ning ◽  
Hongran Zhang ◽  
Cong Wang ◽  
Xiuqi Song
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cancer Associated Fibroblasts ◽  
Gastric Cancer Cells

scholarly journals SAA1 is upregulated in gastric cancer-associated fibroblasts possibly by its enhancer activation

2020 ◽  
Author(s):  
Yoshimi Yasukawa ◽  
Naoko Hattori ◽  
Naoko Iida ◽  
Hideyuki Takeshima ◽  
Masahiro Maeda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Chromatin Immunoprecipitation ◽  
Therapeutic Target ◽  
Cancer Associated Fibroblasts ◽  
Promoting Effect ◽  
Gastric Cancer Cells ◽  
Potential Therapeutic Target ◽  
Active Enhancer ◽  
Serum Amyloid A1

Abstract Cancer-associated fibroblasts (CAFs) tend to have tumor-promoting capacity, and can provide therapeutic targets. Even without cancer cells, CAF phenotypes are stably maintained, and DNA methylation and H3K27me3 changes have been shown to be involved. Here, we searched for a potential therapeutic target in primary CAFs from gastric cancer and a mechanism for its dysregulation. Expression microarray using eight CAFs and seven non-CAFs (NCAFs) revealed that serum amyloid A1 (SAA1), which encodes an acute phase secreted protein, was second most upregulated in CAFs, following IGF2. Conditioned medium (CM) derived from SAA1-overexpressing NCAFs was shown to increase migration of gastric cancer cells compared to that from control NCAFs, and its tumor-promoting effect was comparable to that of CM from CAFs. In addition, increased migration of cancer cells by CM from CAFs was mostly canceled with CM from CAFs with SAA1 knockdown. Chromatin immunoprecipitation (ChIP)-quantitative PCR showed that CAFs had higher levels of H3K27ac, an active enhancer mark, in the promoter and the two far upstream regions of SAA1 than NCAFs. Also, BET bromodomain inhibitors, JQ1 and mivebresib, decreased SAA1 expression and tumor-promoting effects in CAFs, suggesting SAA1 upregulation by enhancer activation in CAFs. Our present data showed that SAA1 is a candidate therapeutic target from gastric CAFs and indicated that increased enhancer acetylation is important for its overexpression.

Abstract 2368: Differentiated gastric cancer cells have a potential to induce cancer-associated fibroblasts

2015 ◽  
Author(s):  
Yuncheng Li ◽  
Hiroshi Tazawa ◽  
Nishizaki Masahiko ◽  
Yuuri Hashimoto ◽  
Naoto Hori ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cancer Associated Fibroblasts ◽  
Gastric Cancer Cells

scholarly journals Exosomal miRNA-34 from cancer-associated fibroblasts inhibits growth and invasion of gastric cancer cells in vitro and in vivo

Aging ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 8549-8564 ◽  
Author(s):  
Liang Shi ◽  
Zhenyong Wang ◽  
Xiuchao Geng ◽  
Yuhao Zhang ◽  
Ziqing Xue
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cancer Associated Fibroblasts ◽  
Gastric Cancer Cells ◽  
Exosomal Mirna

scholarly journals Effects of cancer-associated fibroblasts on the migration and invasion abilities of SGC-7901 gastric cancer cells

2012 ◽  
Vol 5 (2) ◽  
pp. 609-612 ◽  
Author(s):  
CHENGYI HU ◽  
ZHENGCAI WANG ◽  
LILI ZHAI ◽  
MILING YANG ◽  
LIHUI SHAN ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Cancer Associated Fibroblasts ◽  
Gastric Cancer Cells
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